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Li Han
Northeastern University
Organic chemistryChemistryBiochemistryBiologyMicrobiology
60Publications
8H-index
249Citations
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Publications 63
Newest
#1Hao Su (NU: Northeastern University)H-Index: 2
#2Caijuan Hu (NU: Northeastern University)H-Index: 2
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
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In the process of investigating the antifungal structure-activity relationships (SAR) of borrelidin and discovering antifungal leads, a semisynthetic borrelidin analogue, BN-3b with antifungal activity against Candida albicans, was achieved. In this study, we found that oxidative damage induced by endogenous reactive oxygen species (ROS) plays an important role in the antifungal activity of BN-3b. Further investigation indicated that BN-3b stimulated ROS accumulation, increased malondialdehyde (...
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#1Peipei Guan (NU: Northeastern University)H-Index: 3
#2Xingbo Wang (NU: Northeastern University)H-Index: 3
Last. Cheng-Lin Jiang (Yunnan University)H-Index: 31
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Abstract Three pyrrol-2-aldehyde derivatives, including one new compound, jiangrine G (JG), two known compounds, jiangrine A (JA), and pyrrolezanthine (PZ), were isolated from the fermentation broth of Jiangella alba associated with a traditional Chinese medicinal plant Maytenus austroyunnanensis. The structure of jiangrine G was elucidated by a detailed spectroscopic data analysis including data from CD spectra. The anti-inflammatory activities assay demonstrated that JG and JA suppressed the p...
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#1Qingyin Liu (NU: Northeastern University)
#2Yu Mu (NU: Northeastern University)H-Index: 7
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
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Abstract A concise total synthesis of an exceedingly potent anti-inflammatory agent violacin A as well as the preparation of thirty analogues of this lead from commercially available orcinol are described. Highlights of our synthetic efforts involve Friedel-Crafts acylation, the regioselective etherification and esterification of phenolic hydroxyl groups, and Baker-Venkatamaran rearrangement to form basic skeleton of violacin A. The deprotection reaction with Pd-catalytic was involved to avoid t...
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#1Gui-Ding Li (NU: Northeastern University)H-Index: 2
#2Yi Jiang (Yunnan University)H-Index: 14
Last. Cheng-Lin Jiang (Yunnan University)H-Index: 31
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A yellow, Gram-stain-negative, aerobic, non-gliding, non-spore-forming, rod-shaped strain, designated YIM 102600T, was isolated from the faeces of Macaca mulatta dwelling in the Yunnan Wild Animal Park, Yunnan Province, South-West PR China. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain YIM 102600T was a member of the genus Flavobacterium , and closely related to Flavobacterium qiangtangense F3T (96.9 % similarity) and Flavobacterium noncentrifugens R-HLS-17T (96.0 % s...
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#1Yu Mu (NU: Northeastern University)H-Index: 7
#2Xiuyang Yu (NU: Northeastern University)
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
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#1Xiaoxiao Gao (NU: Northeastern University)H-Index: 2
#2Hongzhi Yao (NU: Northeastern University)
Last. Cheng-Lin Jiang (Yunnan University)H-Index: 31
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Abstract Spectinabilin (1), spectinabilin derivative (2), and a new analogue, 2-demethyl-spectinabilin (3) were isolated from the fermentation broth of a soil-borne Streptomyces spectabilis strain. The structure of the new compound was elucidated by a detailed spectroscopic data analysis including data from CD spectra. Spectinabilin (1) demonstrated cytotoxicity against five human cancer cell lines, with IC50 values ranging from 18.7 ± 3.1 to 34.6 ± 4.7 μM, while derivatives 2 and 3 showed weak ...
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#1Xiao Chen (MOE: Chinese Ministry of Education)
#2Lin-Fang Hu (MOE: Chinese Ministry of Education)
Last. Yiqing Li (MOE: Chinese Ministry of Education)H-Index: 1
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ABSTRACT:Three new phenazine metabolites strepphenazine A–C (1–3), along with a known compound baraphenazine E 4 were isolated from the culture broth of a Streptomyces strain YIM PH20095. The structures were elucidated based on the spectral data. Compounds 1–4 showed different antifungal activity against Fusarium oxysporum, Plectosphaerella cucumerina, Alternaria panax, and Phoma herbarum, which caused root-rot disease of Panax notoginseng with minimal inhibitory concentrations (MICs) of 16-64 μ...
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#1Guiding Li (Yunnan University)H-Index: 3
#2Xiu Chen (Yunnan University)H-Index: 5
Last. Cheng-Lin Jiang (Yunnan University)H-Index: 31
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Strains YIM 102796T and YIM 102701-2T were isolated from the feces of Macaca mulatta and Hylobates hoolock, respectively, living in the Yunnan Wild Animal Park, Yunnan province of China. The two strains were Gram-stain-negative, non-gliding, produced flexirubin pigments, non-flagellated and aerobic bacteria. The 16S rRNA gene-based phylogenetic analysis indicate that both YIM 102796T and YIM 102701-2T are members of the genus Flavobacterium, closely related to F. ummariense DS-12T (95.9% similar...
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#1Lin-Fang Hu (MOE: Chinese Ministry of Education)
#2Xiao Chen (MOE: Chinese Ministry of Education)
Last. Yiqing Li (MOE: Chinese Ministry of Education)H-Index: 1
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Two new phenazine metabolites, 6-hydroxyphenazine-1-carboxamide (1) and methyl 6-carbamoylphenazine-1-carboxylate (2), were isolated from a soil-derived Streptomyces diastaticus subsp. ardesiacus strain YIM PH20246, and their structures were elucidated by extensive spectroscopic data analysis. The antimicrobial activities of the isolates were assayed. Compound 1 showed moderate antifungal and antibacterial activities against Fusarium oxysporum (ATCC 7808), Fusarium solani (ATCC 36031) and Plecto...
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#1Xin-Dong Xu (Yunnan University)H-Index: 1
#2Li Han (NU: Northeastern University)H-Index: 8
Last. Yi-Qing Li (Yunnan University)H-Index: 4
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Actinomycete strain YIM PH20520, isolated from the rhizosphere soil sample of Panax notoginseng collected in Wenshang, Yunnan Province, China, exhibited antifungal activity against root-rot pathogens of the Panax notoginseng. The structures of bioactive molecules, isolated from the ethyl acetate extract of the fermentation broth of the strain, were identified as echinosporin (1) and 7-deoxyechinosporin (2) based on extensive spectroscopic analyses. 1 exhibited antifungal activity against four te...
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