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Xiongxiong Lu
Shanghai Jiao Tong University
19Publications
7H-index
266Citations
Publications 19
Newest
#1Kun Wang (SJTU: Shanghai Jiao Tong University)H-Index: 18
#2Xiongxiong Lu (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last.W.J. Ding (SJTU: Shanghai Jiao Tong University)H-Index: 23
view all 7 authors...
Abstract In this work, a novel Al-P-O (Al-6Si-2.5P-Al2O3) master alloy has been developed via the in-situ salt-melt reaction route. The primary Si refinement and eutectic Si modification have been simultaneously achieved in hypereutectic Al 30Si alloy upon addition of Al-P-O master alloys. The refined and homogeneous microstructure leads to an improvement in the mechanical properties, especially ductility. Compared with the conventional Al P master alloys, the ultimate tensile strength and elong...
#1Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Hongzhe Li (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last.Yuan Fang (SJTU: Shanghai Jiao Tong University)H-Index: 6
view all 12 authors...
Long non-coding RNAs (lncRNAs) play crucial roles in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). Previously, we found that melittin treatment suppressed PDAC tumor growth. However, it is unclear whether lncRNAs have any role in the melittin-induced suppression of PDAC. In this study, we used microarray data to identify 844 lncRNAs that were significantly differentially expressed in response to melittin treatment. Of these lncRNAs, we focused on the lncRNA NONHSAT105177, which ha...
#1Yiran Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Wei Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last.Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 9 authors...
Abstract Background Biliary fistula (BF) is a major surgical complication that can develop after pancreaticoduodenectomy (PD) whose risk factors remain unclear. Substantial atherosclerotic celiac axis stenosis (SACAS) has not been reported to be one of them. Methods Data from 507 patients undergoing PD between Jan 1, 2013 and Dec 31, 2015 were retrospectively collected. Clinical data from patients with SACAS were studied, and the independent risk factors for BF underwent multivariate logistic re...
#1Yuan Fang (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Zhe Su (PKU: Peking University)H-Index: 5
Last.Hongwei Li (SJTU: Shanghai Jiao Tong University)H-Index: 13
view all 13 authors...
In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents ∼4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC ha...
#1Hongzhe LiH-Index: 3
#2Xinjing WangH-Index: 6
Last.Baiyong ShenH-Index: 18
view all 9 authors...
// Hongzhe Li 1, 2, 3, * , Xinjing Wang 1, 2, 3, * , Yuan Fang 1, 2, 3 , Zhen Huo 1, 2 , Xiongxiong Lu 1, 3 , Xi Zhan 1, 3 , Xiaxin Deng 1, 3 , Chenghong Peng 1, 3 and Baiyong Shen 1, 2, 3 1 Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China 2 Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China 3 Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, S...
#1Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Jing Xie (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last.Hao Chen (SJTU: Shanghai Jiao Tong University)H-Index: 15
view all 14 authors...
Abstract Melittin is a Chinese traditional medicine for treating chronic inflammation, immunological diseases and cancers, however, the efficacy of melittin and its mechanism for treating pancreatic ductal adenocarcinoma (PDAC) are still unknown. Here we investigated the anti-cancer activity of melittin and its regulated mechanism(s) in the PDAC models. Melittin was found to suppress tumor growth by promoting cell apoptosis and cell-cycle arrest. Interestingly, the microarray analyses demonstrat...
#1Y. Xiao (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Wei LiH-Index: 14
Last.Xuejun Jin (SJTU: Shanghai Jiao Tong University)H-Index: 18
view all 5 authors...
Abstract Low temperature tempering is important in improving the mechanical properties of steels. In this study, the thermoelectric power method was employed to investigate carbon segregation during low temperature tempering ranging from 110 °C to 170 °C of a medium carbon alloyed steel, combined with micro-hardness, transmission electron microscopy and atom probe tomography. Evolution of carbon dissolution from martensite and segregation to grain boundaries/interfaces and dislocations were inve...
#1Jing Xie (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Xiongxiong Lu (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last.Xiaomei Tang (SJTU: Shanghai Jiao Tong University)H-Index: 3
view all 19 authors...
Background Targeted therapies including monoclonal antibodies and small molecule inhibitors have dramatically changed the treatment of cancer over past 10 years. Their therapeutic advantages are more tumor specific and with less side effects. For precisely tailoring available targeted therapies to each individual or a subset of cancer patients, next-generation sequencing (NGS) has been utilized as a promising diagnosis tool with its advantages of accuracy, sensitivity, and high throughput. Metho...
#1Xinjing WangH-Index: 6
#2Xiongxiong LuH-Index: 7
Last.Yuan FangH-Index: 6
view all 12 authors...
// Xinjing Wang 1,2,3,* , Xiongxiong Lu 1,2,3,* , Tian Zhang 1,2,3,* , Chenlei Wen 1,2,3 , Minmin Shi 3 , Xiaomei Tang 1,2,3 , Hao Chen 1,2,3 , Chenghong Peng 1,2,3 , Hongwei Li 1 , Yuan Fang 1,2,3 , Xiaxing Deng 1,2,3 and Baiyong Shen 1,2,3 1 Research Institute of Pancreatic Disease, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 2 Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 3 Shanghai Instit...
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