Xiongxiong Lu
Shanghai Jiao Tong University
Pancreatic cancerAdenocarcinomaCancer researchMedicineBiology
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Publications 24
Background: Pancreatic cancer is an extremely lethal digestive cancer with late diagnosis and poor prognosis. miR-934 has been reported to serve as an oncogene in multiple cancers, such as ovarian cancer and bladder cancer. However, its role in pancreatic cancer remains undiscovered. Materials and Methods: The expression data of miR-934 were obtained from the Gene Expression Omnibus database and from our own patient samples. The clinicopathological data and corresponding follow-up data were retr...
#1Shuyu Zhai (SJTU: Shanghai Jiao Tong University)
#2Zhen Huo (SJTU: Shanghai Jiao Tong University)H-Index: 6
Last. Xiaxing Deng (SJTU: Shanghai Jiao Tong University)H-Index: 15
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BACKGROUND Pancreatic cancer is a highly malignant tumor characterized by poor prognosis. TNM stage cannot always provide accurate prediction of prognosis, which is vital for individualized treatment. Therefore, a novel way to identify patients with poor prognosis after radical surgery is urgently needed. MATERIAL AND METHODS The nomogram was established based on a discovery cohort that included 554 patients with PDAC who had received radical surgery from 2012 to 2016. The clinicopathological da...
Glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) plays a critical role in cancer metabolism by coordinating glycolysis and biosynthesis. A well-validated PGAM1 inhibitor, however, has not been reported for treating pancreatic ductal adenocarcinoma (PDAC), which is one of the deadliest malignancies worldwide. By uncovering the elevated PGAM1 expressions were statistically related to worse prognosis of PDAC in a cohort of 50 patients, we developed a series of allosteric PGAM1 inhibitors by stru...
1 CitationsSource
#1Kun Wang (SJTU: Shanghai Jiao Tong University)H-Index: 28
#2Xiongxiong Lu (SJTU: Shanghai Jiao Tong University)H-Index: 8
Last. W.J. Ding (SJTU: Shanghai Jiao Tong University)H-Index: 20
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Abstract In this work, a novel Al-P-O (Al-6Si-2.5P-Al2O3) master alloy has been developed via the in-situ salt-melt reaction route. The primary Si refinement and eutectic Si modification have been simultaneously achieved in hypereutectic Al 30Si alloy upon addition of Al-P-O master alloys. The refined and homogeneous microstructure leads to an improvement in the mechanical properties, especially ductility. Compared with the conventional Al P master alloys, the ultimate tensile strength and elong...
#1Xinjing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 7
#2Hongzhe Li (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
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Long non-coding RNAs (lncRNAs) play crucial roles in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). Previously, we found that melittin treatment suppressed PDAC tumor growth. However, it is unclear whether lncRNAs have any role in the melittin-induced suppression of PDAC. In this study, we used microarray data to identify 844 lncRNAs that were significantly differentially expressed in response to melittin treatment. Of these lncRNAs, we focused on the lncRNA NONHSAT105177, which ha...
7 CitationsSource
#1Yiran Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Wei Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
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Abstract Background Biliary fistula (BF) is a major surgical complication that can develop after pancreaticoduodenectomy (PD) whose risk factors remain unclear. Substantial atherosclerotic celiac axis stenosis (SACAS) has not been reported to be one of them. Methods Data from 507 patients undergoing PD between Jan 1, 2013 and Dec 31, 2015 were retrospectively collected. Clinical data from patients with SACAS were studied, and the independent risk factors for BF underwent multivariate logistic re...
1 CitationsSource
#1Yuan Fang (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Zhe Su (PKU: Peking University)H-Index: 6
Last. Baiyong Shen (SJTU: Shanghai Jiao Tong University)H-Index: 18
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In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents ∼4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC ha...
6 CitationsSource
#1Hongzhe LiH-Index: 4
#2Xinjing WangH-Index: 7
Last. Baiyong ShenH-Index: 18
view all 9 authors...
// Hongzhe Li 1, 2, 3, * , Xinjing Wang 1, 2, 3, * , Yuan Fang 1, 2, 3 , Zhen Huo 1, 2 , Xiongxiong Lu 1, 3 , Xi Zhan 1, 3 , Xiaxin Deng 1, 3 , Chenghong Peng 1, 3 and Baiyong Shen 1, 2, 3 1 Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China 2 Research Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China 3 Pancreatic Disease Centre, Ruijin Hospital, School of Medicine, S...
14 CitationsSource