Match!
D Birnbaum
French Institute of Health and Medical Research
122Publications
34H-index
4,423Citations
Publications 122
Newest
Published on May 1, 2019in Annals of Oncology14.20
Steven Van Laere33
Estimated H-index: 33
(University of Antwerp),
Pascal Finetti42
Estimated H-index: 42
+ 5 AuthorsFrançois Bertucci28
Estimated H-index: 28
(AMU: Aix-Marseille University)
Published on Apr 30, 2019in Journal of Clinical Medicine
D Birnbaum34
Estimated H-index: 34
,
David Jérémie Birnbaum + 2 AuthorsFrançois Bertucci53
Estimated H-index: 53
Pancreatic adenocarcinoma (PAC) is one of the most aggressive human cancers and new systemic therapies are urgently needed. Exportin-1 (XPO1), which is a member of the importin-β superfamily of karyopherins, is the major exporter of many tumor suppressor proteins that are involved in the progression of PAC. Promising pre-clinical data using XPO1 inhibitors have been reported in PAC, but very few data are available regarding XPO1 expression in clinical samples. Retrospectively, we analyzed XPO1 m...
Published on Apr 8, 2019in Cancers
D Birnbaum34
Estimated H-index: 34
,
David Jérémie Birnbaum + 2 AuthorsEmilie Mamessier20
Estimated H-index: 20
The association between pancreatic ductal adenocarcinoma (PDAC) location (head vs. Body/Tail (B/T)) and clinical outcome remains controversial. We collected clinicopathological and gene expression data from 249 resected PDAC samples from public data sets, and we compared data between 208 head and 41 B/T samples. The 2-year overall survival (OS) was better for the head than for the B/T PDACs (44 vs. 27%, p = 0.043), especially when comparing tumors with similar TNM classification (T3/4N0M0: 67% v...
Published on Apr 1, 2019in Surgery3.48
Théophile Guilbaud2
Estimated H-index: 2
,
D Birnbaum34
Estimated H-index: 34
,
David Jérémie Birnbaum
Published on Nov 1, 2018in Annals of Surgery9.48
Marta Sandini9
Estimated H-index: 9
,
Kim C. Honselmann5
Estimated H-index: 5
+ 13 AuthorsVincent Moutardier29
Estimated H-index: 29
Published on Feb 15, 2018in Cancer Research8.38
Emmanuelle Charafe-Jauffret44
Estimated H-index: 44
,
Julien Wicinski12
Estimated H-index: 12
+ 9 AuthorsFrançois Bertucci28
Estimated H-index: 28
Published on Dec 1, 2017in Annals of Translational Medicine
Emilie Mamessier20
Estimated H-index: 20
,
D Birnbaum34
Estimated H-index: 34
+ 2 AuthorsFrançois Bertucci53
Estimated H-index: 53
In the early 1990s, the team of Dr. Honjo identified a new gene that was upregulated during T-cell activation, supposedly as an apoptosis-associated molecule (1). This gene was named programmed cell death-1 ( PD-1 or CD279 or PDCD1 ). The PD-1 protein turned out to be a receptor delivering a co-inhibitory signal, playing a decisive role in maintaining peripheral tolerance and impeding autoimmunity, but with no effect on cell apoptosis. In 2000, Drs. Freeman and Sharpe discovered the natural liga...
12345678910