D Birnbaum
French Institute of Health and Medical Research
Publications 90
#1Steven Van Laere (University of Antwerp)H-Index: 35
#2Pascal FinettiH-Index: 43
Last.François Bertucci (AMU: Aix-Marseille University)H-Index: 32
view all 8 authors...
#1Steven Van LaereH-Index: 35
#2Pascal FinettiH-Index: 43
Last.François BertucciH-Index: 32
view all 9 authors...
#2Julien WicinskiH-Index: 12
Last.Christophe GinestierH-Index: 43
view all 12 authors...
#1Nathalie CerveraH-Index: 26
#2N CarbucciaH-Index: 5
Last.Véronique Gelsi-BoyerH-Index: 25
view all 11 authors...
Molecular characterization of acute erythroid leukemia (M6-AML) using targeted next-generation sequencing
11 CitationsSource
#1A GonçalvesH-Index: 7
#2François BertucciH-Index: 32
Last.D BirnbaumH-Index: 31
view all 26 authors...
Background Genomic-based approaches in advanced breast cancer (ABC) were recently demonstrated as feasible in the clinical practice, but only a limited number of patients were actually treated with targeted therapies matching genomic alterations, with low antitumor activity. We conducted a pilot study to evaluate whether precision medicine using NGS and aCGH could be implemented prospectively at a single center in ABC patients. In addition, we examined whether PDX could be derived from ABC and t...
#1Véronique ChevrierH-Index: 12
#2Frédérique LemboH-Index: 11
Last.Olivier RosnetH-Index: 29
view all 6 authors...
Stable microtubules organized on the basis of a nine-fold rotational symmetry constitute the structural basis of centrioles and basal bodies. A number of proteins associate with these structures to drive the process of centrosomes and cilia formation and to participate in their function. Pericentriolar satellites are small round-shaped particles closely associated with microtubules with PCM1 as a major component. To date they have been described only in vertebrates where they participate in the ...
#1Emilie CoppinH-Index: 7
Last.Jacques A. NunèsH-Index: 25
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Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML)
7 CitationsSource
Last.D BirnbaumH-Index: 31
view all 21 authors...
#1François BertucciH-Index: 32
#2Pascal FinettiH-Index: 43
Last.D BirnbaumH-Index: 31
view all 9 authors...
Gastrointestinal stromal tumours (GISTs) are the most frequent mesenchymal digestive tumours (Kitamura et al, 2003; Corless et al, 2011). Characterised by activating KIT or PDGFRA mutations, which rend them sensitive to tyrosine kinase inhibitors (imatinib and sunitinib), they represent a model for molecular-based diagnosis (West et al, 2004) and treatment (Antonescu, 2011; Joensuu and Dematteo, 2012). The mainstay of treatment for localised tumour is complete surgical resection (Casali and Blay...
10 CitationsSource
#1S CornenH-Index: 2
#2José AdélaïdeH-Index: 50
Last.Max ChaffanetH-Index: 37
view all 8 authors...
Mamo et al. (2011) identified ARID1A as a candidate tumor suppressor gene (TSG) in breast cancer (BC) by an integrated genomic approach. They reported loss of heterozygosity of the ARID1A locus at 1p36.11 in 13% of 82 analyzed BC samples, and an ARID1A nonsense mutation in one out of five BC cell lines. However, they did not find any ARID1A mutation in 11 analyzed BC samples. Low ARID1A RNA expression and nuclear protein expression were associated with aggressive BC phenotypes in two series of ~...
37 CitationsSource