David J. Lythgoe
King's College London
Publications 101
#1Michael C. Craig ('KCL': King's College London)H-Index: 29
#2Leandra M Mulder (Radboud University Nijmegen)H-Index: 1
Last.Jilly Naaijen (Radboud University Nijmegen)H-Index: 6
view all 23 authors...
Abstract Disruptive behavior is associated with societally and personally problematic levels of aggression and has been linked to abnormal structure and function of fronto-amygdala-striatal regions. Abnormal glutamatergic signalling within this network may play a role in aggression. However, disruptive behavior does not represent a homogeneous construct, but can be fractionated across several dimensions. Of particular interest, callous-unemotional (CU) traits have been shown to modulate the seve...
#1Faith Borgan (Imperial College London)H-Index: 1
#2Sameer Jauhar ('KCL': King's College London)H-Index: 14
Last.Oliver D. Howes (Imperial College London)H-Index: 52
view all 7 authors...
Converging lines of evidence suggest that glutamatergic dysfunction may contribute to the pathophysiology of first episode psychosis. We investigated whether first episode psychosis patients free from all pharmacological treatments and illicit substances show cortical glutamatergic alterations. One-hundred and eleven volunteers including 65 healthy volunteers and 46 first episode psychosis patients free from all pharmacological treatments (28 drug naive) underwent a proton magnetic resonance spe...
#1Charlotte M. Pretzsch ('KCL': King's College London)H-Index: 1
#2Bogdan I. Voinescu ('KCL': King's College London)H-Index: 7
Last.Grainne M. McAlonan ('KCL': King's College London)H-Index: 36
view all 14 authors...
Autism spectrum disorder (ASD) is a high cost neurodevelopmental condition; and there are currently no effective pharmacological treatments for its core symptoms. This has led some families and researchers to trial alternative remedies – including the non-intoxicating Cannabis sativa-derived compound cannabidivarin (CBDV). However, how CBDV affects the human brain is unknown. Previous (pre)clinical evidence suggests that CBDV may modulate brain excitatory-inhibitory systems, which are implicated...
#1Grant McQueen ('KCL': King's College London)H-Index: 7
#2Aderlee Lay ('KCL': King's College London)
Last.Alice Egerton ('KCL': King's College London)H-Index: 32
view all 11 authors...
Rationale There is interest in employing N-acetylcysteine (NAC) in the treatment of schizophrenia, but investigations of the functional signatures of its pharmacological action are scarce.
#1Grace Blest-Hopley ('KCL': King's College London)H-Index: 2
#2Aisling O’Neill ('KCL': King's College London)H-Index: 4
Last.Sagnik Bhattacharyya ('KCL': King's College London)H-Index: 33
view all 7 authors...
#1Elenor Morgenroth (University of Roehampton)H-Index: 1
#2Natasza Orlov ('KCL': King's College London)H-Index: 6
Last.Paul Allen ('KCL': King's College London)H-Index: 43
view all 8 authors...
Abstract Trait anxiety can affect cognitive control resulting in ineffective and/or inefficient task performance. Moreover, previous functional Magnetic Resonance Imaging (fMRI) studies have reported altered dorsolateral prefrontal cortex (DLPFC) activity in anxious cohorts, particularly when executive control is required. Recently, it has been demonstrated that cortical glutamate levels can predict both functional activation during cognitive control, and anxiety levels. In the present study we ...
1 CitationsSource
#1Charlotte M. Pretzsch ('KCL': King's College London)H-Index: 1
#2Jan Freyberg ('KCL': King's College London)H-Index: 1
Last.Grainne M. McAlonan ('KCL': King's College London)H-Index: 36
view all 15 authors...
There is increasing interest in the use of cannabis and its major non-intoxicating component cannabidiol (CBD) as a treatment for mental health and neurodevelopmental disorders, such as autism spectrum disorder (ASD). However, before launching large-scale clinical trials, a better understanding of the effects of CBD on brain would be desirable. Preclinical evidence suggests that one aspect of the polypharmacy of CBD is that it modulates brain excitatory glutamate and inhibitory γ-aminobutyric ac...
1 CitationsSource
#1Musa SamiH-Index: 5
#2Amanda WorkerH-Index: 4
Last.Sagnik BhattacharyyaH-Index: 33
view all 6 authors...
#1Cathy Davies ('KCL': King's College London)H-Index: 10
#2Grazia Rutigliano ('KCL': King's College London)H-Index: 14
Last.Paolo Fusar-PoliH-Index: 66
view all 20 authors...
Abstract Alterations in neurochemical metabolites are thought to play a role in the pathophysiology of psychosis onset. Oxytocin, a neuropeptide with prosocial and anxiolytic properties, modulates glutamate neurotransmission in preclinical models but its neurochemical effects in people at high risk for psychosis are unknown. We used proton magnetic resonance spectroscopy (1H-MRS) to examine the effects of intranasal oxytocin on glutamate and other metabolites in people at Clinical High Risk for ...
1 CitationsSource
#1Marco Colizzi ('KCL': King's College London)H-Index: 13
#2Nathalie Weltens (Katholieke Universiteit Leuven)H-Index: 7
Last.Sagnik Bhattacharyya ('KCL': King's College London)H-Index: 33
view all 7 authors...