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Hong Wei
Sun Yat-sen University
102Publications
21H-index
1,640Citations
Publications 102
Newest
#1Peng Zheng (CQMU: Chongqing Medical University)H-Index: 18
#2Yi-Fan Li (CQMU: Chongqing Medical University)
Last.Peng Xie (CQMU: Chongqing Medical University)H-Index: 30
view all 17 authors...
#1Xiaoyu Liao (Third Military Medical University)H-Index: 3
#2Lingyu Song (Third Military Medical University)H-Index: 2
Last.Hongting Zheng (Third Military Medical University)H-Index: 10
view all 22 authors...
Abstract Background Increasing evidence indicates that the gut microbiota contributes to the occurrence and development of metabolic diseases. However, little is known about the effects of commonly used antidiabetic agents on the gut microbiota. In this study, we investigated the roles of dipeptidyl peptidase-4 inhibitors (DPP-4i) and α-glucosidase inhibitor in modulating the gut microbiota. Methods 16S-rDNA sequencing was performed to analyse the effects of DPP-4i and acarbose on the gut microb...
#1Junxi PanH-Index: 7
#2Feng-Li DengH-Index: 2
Last.Peng Xie (CQMU: Chongqing Medical University)H-Index: 30
view all 12 authors...
Abstract The gut microbiome is composed of an enormous number of microorganisms, generally regarded as commensal bacteria. Resident gut bacteria are an important contributor to health and significant evidence suggests that the presence of healthy and diverse gut microbiota is important for normal cognitive and emotional processing. Here we measured the expression of monoamine neurotransmitter-related genes in the hippocampus of germ-free (GF) mice and specific-pathogen-free (SPF) mice to explore...
#1Xunzhong Qi (CQMU: Chongqing Medical University)H-Index: 2
Last.Peng XieH-Index: 30
view all 13 authors...
Abstract Aims The microbiota has a profound impact on host development and function. Axon guidance is essential for the formation of neural circuits and plays an important role in neurological diseases and behavioral disorders. However, the impact of the microbiota on axon guidance signaling is unclear. Main methods Gnotobiotic models-germ free mice were applied to explore behavioral phenotypes and possible molecular mechanisms that were evaluated by Realtime-PCR and western blot analysis. Prima...
#1Xiao Wang (CAS: Chinese Academy of Sciences)H-Index: 4
#2Chunwei Cao (CAS: Chinese Academy of Sciences)H-Index: 10
Last.Jianguo Zhao (CAS: Chinese Academy of Sciences)H-Index: 19
view all 19 authors...
#1Bolei Li (Sichuan University)H-Index: 4
#2Yang Ge (Sichuan University)H-Index: 5
Last.Xuedong Zhou (Sichuan University)H-Index: 35
view all 12 authors...
The oral microbiota is associated with oral diseases and digestive systemic diseases. Nevertheless, the causal relationship between them has not been completely elucidated, and colonisation of the gut by oral bacteria is not clear due to the limitations of existing research models. The aim of this study was to develop a human oral microbiota-associated (HOMA) mouse model and to investigate the ecological invasion into the gut. By transplanting human saliva into germ-free (GF) mice, a HOMA mouse ...
#1Peng Zheng (CQMU: Chongqing Medical University)H-Index: 18
#2Benhua Zeng (Third Military Medical University)H-Index: 15
Last.Peng Xie (CQMU: Chongqing Medical University)H-Index: 30
view all 17 authors...
Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying molecular mechanisms. The gut microbiome can modulate brain function and behaviors through the microbiota-gut-brain axis. Here, we found that unmedicated and medicated patients with SCZ had a decreased microbiome α-diversity index and marked disturbances of gut microbial composition versus healthy controls (HCs). Several unique bacterial taxa (e.g., Veillonellaceae and Lachnospiraceae) were associated with SCZ se...
#1Yuanyuan Luo (CQMU: Chongqing Medical University)H-Index: 3
#2Benhua Zeng (Third Military Medical University)H-Index: 15
Last.Peng XieH-Index: 30
view all 14 authors...
Gut microbiota has an important role in the immune system, metabolism, and digestion, and has a significant effect on the nervous system. Recent studies have revealed that abnormal gut microbiota induces abnormal behaviors, which may be associated with the hypothalamic–pituitary–adrenal (HPA) axis. Therefore, we investigated the behavioral changes in germ-free (GF) mice by behavioral tests, quantified the basal serum cortisol levels, and examined glucocorticoid receptor pathway genes in hippocam...
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