A. Molinaro
University of Gothenburg
Publications 42
#1Nienke Koopman (UvA: University of Amsterdam)H-Index: 1
#2A. Molinaro (University of Gothenburg)H-Index: 5
Last.Adriaan G. Holleboom (UvA: University of Amsterdam)H-Index: 19
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Background: Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver condition. A major current research effort is ongoing to find potential strategies to treat NAFLD-non-alcoholic steatohepatitis (NASH), with special attention to the gut microbiota. Multiple animal studies and pilot clinical trials are assessing different gut microbiota modulating strategies such as faecal microbiota transplantation, antibiotics, probiotics, prebiotics and synbiotics. Aim: To review th...
1 CitationsSource
#1Angela Molinaro (University of Gothenburg)
#2Barbara Becattini (University of Gothenburg)H-Index: 13
Last.Giovanni Solinas (University of Gothenburg)H-Index: 21
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Summary Phosphatidylinositol-3-kinase (PI3K) activity is aberrant in tumors, and PI3K inhibitors are investigated as cancer therapeutics. PI3K signaling mediates insulin action in metabolism, but the role of PI3K isoforms in insulin signaling remains unresolved. Defining the role of PI3K isoforms in insulin signaling is necessary for a mechanistic understanding of insulin action and to develop PI3K inhibitors with optimal therapeutic index. We show that insulin-driven PI3K-AKT signaling depends ...
#1F. Ferri (Sapienza University of Rome)H-Index: 4
#2Quirino Lai (Sapienza University of Rome)H-Index: 17
Last.Stefano Ginanni Corradini (Sapienza University of Rome)H-Index: 23
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Background. No data are available on liver transplantation (LT) outcome and donor liver steatosis, classified as large droplet macrovesicular (Ld-MaS), small-droplet macrovesicular (Sd-MaS), and true microvesicular (MiS), taking into account the recipient Hepatitis C virus (HCV) status. Aim. We investigate the impact of allograft steatosis reclassified according to the Brunt classification on early graft function and survival after LT. Methods. We retrospectively reviewed 204 consecutive preisch...
#1A. Molinaro (University of Gothenburg)H-Index: 5
#2Robert Caesar (University of Gothenburg)H-Index: 16
Last.Fredrik Bäckhed (UCPH: University of Copenhagen)H-Index: 75
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Abstract Objectives The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an important nuclear receptor involved in several biological processes. RORα full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here w...
#1Ara Koh (Sahlgrenska University Hospital)H-Index: 2
#2A. Molinaro (Sahlgrenska University Hospital)H-Index: 5
Last.Fredrik Bäckhed (UCPH: University of Copenhagen)H-Index: 75
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Summary Interactions between the gut microbiota, diet, and the host potentially contribute to the development of metabolic diseases. Here, we identify imidazole propionate as a microbially produced histidine-derived metabolite that is present at higher concentrations in subjects with versus without type 2 diabetes. We show that imidazole propionate is produced from histidine in a gut simulator at higher concentrations when using fecal microbiota from subjects with versus without type 2 diabetes ...
33 CitationsSource
#1A. MolinaroH-Index: 5
#1F. FerriH-Index: 4
#2A. MolinaroH-Index: 5
view all 15 authors...
#1A. Molinaro (University of Gothenburg)H-Index: 5
#2Annika Wahlström (University of Gothenburg)H-Index: 10
Last.Hanns-Ulrich Marschall (University of Gothenburg)H-Index: 52
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Bile acids are endocrine molecules that in addition to facilitating the absorption of fat-soluble nutrients regulate numerous metabolic processes, including glucose, lipid, and energy homeostasis. The signaling actions of bile acids are mediated through specific bile-acid-activated nuclear and membrane-bound receptors. These receptors are not only expressed by tissues within the enterohepatic circulation such as the liver and the intestine, but also in other organs where bile acids mediate their...
45 CitationsSource
#1A. Molinaro (University of Gothenburg)H-Index: 5
#2Robert Caesar (University of Gothenburg)H-Index: 16
Last.Fredrik Bäckhed (UCPH: University of Copenhagen)H-Index: 75
view all 6 authors...
Abstract Objective Gut microbiota modulates adiposity and glucose metabolism in humans and mice. Here we investigated how colonization of germ-free (GF) mice affects kinetics of adiposity and glucose metabolism. Methods Adiposity and glucose metabolism were evaluated at different time points in ex-GF and antibiotic treated mice after colonization with gut microbiota from a conventionally raised (CONV-R) mouse. Mouse physiology, microbiome configuration, serum cytokine levels, and gene expression...
6 CitationsSource