Chong Liu
Sichuan University
ChemistryMaterials scienceMethacrylamidePeptideBiochemistry
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Publications 4
#1Chong Liu (Sichuan University)H-Index: 4
#2Wei Shan (Sichuan University)H-Index: 13
Last. Yuan Huang (Sichuan University)H-Index: 22
view all 7 authors...
AbstractIn order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the insulin-loaded poly(lactide-co-glycolide)–monomethoxy-poly(polyethylene glycol) micelle cores with FQS modified trimethyl chitosan chloride. In in vitro study, the fabricat...
19 CitationsSource
#1Yining Xu (Sichuan University)H-Index: 4
#2Juan Xu (Sichuan University)H-Index: 4
Last. Yuan Huang (Sichuan University)H-Index: 22
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As for the existence of epithelium barrier, accelerating the transport remains huge challenges for orally delivered protein and peptide drugs into blood circulation. Modifying nanopaticles (NPs) with targeting peptides can enhance the intestinal absorption of loaded macromolecular drugs. However, the transport process, which mainly means how the NPs pass through the apical membrane and the basolateral side and then enter into blood circulation, is needed comprehensive investigation. In this stud...
16 CitationsSource
#1Jiexiu Chen (Sichuan University)H-Index: 1
#2Chong Liu (Sichuan University)H-Index: 4
Last. Yuan Huang (Sichuan University)H-Index: 1
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AbstractOral insulin delivery is often limited by protease degradation. 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate (Camostat mesylate) is reported to have the ability to inhibit trypsin activity, which is the main protease responsible for protein degradation. This study attempted to form a novel nanoparticle by covalently conjugating 4-(2-(2-aminoethylamino)-2-oxoethyl)phenyl 4-guanidinobenzoyloxy (FOY-251), an active derivative of camostat mesylate, to...
12 CitationsSource
#1Yang YangH-Index: 11
#2Lian LiH-Index: 14
Last. Yuan HuangH-Index: 22
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Prostate carcinoma is the second leading cause of cancer-related deaths. Increased expression of membrane-bound galectin-3 by prostate carcinoma cell has been found to correlate with more poorly differentiated and increased metastatic potential. In the present study, different amount of galectin-3-binding peptide, G3-C12 (the sequence ANTPCGPYTHDCPVKR), was attached to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers as targeting moiety. The results of qPCR and competitive binding test indica...
9 CitationsSource