Gang Chen
National Institutes of Health
Publications 99
#1Bernhard M. Meyer (Medical University of Vienna)H-Index: 4
#2Ulrich Rabl (Medical University of Vienna)H-Index: 9
Last.Lukas Pezawas (Medical University of Vienna)H-Index: 31
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Due to lacking predictors of depression recovery, successful treatment of major depressive disorder (MDD) is frequently only achieved after therapeutic optimization leading to a prolonged suffering of patients. This study aimed to determine neural prognostic predictors identifying non-remitters prior or early after treatment initiation. Moreover, it intended to detect time-sensitive neural mediators indicating depression recovery. This longitudinal, interventional, single-arm, open-label, phase ...
1 CitationsSource
#1Xiaoya Du (PKU: Peking University)H-Index: 2
#2Lexia Zhan (PKU: Peking University)H-Index: 2
Last.Jiongjiong Yang (PKU: Peking University)H-Index: 7
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Abstract Studies have shown that the hippocampus plays a crucial role in associative memory. One central issue is whether the involvement of the hippocampus in associative memory remains stable or declines with the passage of time. In the majority of studies, memory performance declines with delay, confounding attempts at interpreting differences in hippocampal activation over time. To address this issue, we tried to equate behavioral performance as much as possible across time for memory of ite...
#1D. A. Handwerker (Ebor: University of York)
Last.David PitcherH-Index: 14
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Humans recognize faces using a network of face-selective regions distributed across the brain. Neuropsychological patient studies demonstrate that focal damage to nodes in this network can impair face recognition, but such patients are rare. We simulated the effects of damage to the face network in neurologically normal human participants using thetaburst transcranial magnetic stimulation (TBS). Multi-echo functional magnetic resonance imaging (fMRI) data were collected pre and post TBS delivery...
#1Gang ChenH-Index: 34
Last.Luiz PessoaH-Index: 4
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2 CitationsSource
#1Rossella Falcone (NIH: National Institutes of Health)
Last.Barry J. Richmond (NIH: National Institutes of Health)H-Index: 34
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The rostromedioventral striatum is critical for behavior dependent on evaluating rewards. We asked what contribution tonically active neurons (TANs), the putative striatal cholinergic interneurons, make in coding reward value in this part of the striatum. Two female monkeys were given the option to accept or reject an offered reward in each trial, the value of which was signaled by a visual cue. 45% of the TANs use temporally modulated activity to encode information about discounted value. These...
#1Gang ChenH-Index: 34
#2Paul A. TaylorH-Index: 14
Last.Luiz Pessoa (UMD: University of Maryland, College Park)H-Index: 4
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Neuroimaging faces the daunting challenge of multiple testing - an instance of multiplicity - that is associated with two other issues to some extent: low inference efficiency and poor reproducibility. Typically, the same statistical model is applied to each spatial unit independently in the approach of massively univariate modeling. In dealing with multiplicity, the general strategy employed in the field is the same regardless of the specifics: trust the local "unbiased" effect estimates while ...
1 CitationsSource
#1Gang Chen (NIH: National Institutes of Health)H-Index: 34
#2Paul A. Taylor (NIH: National Institutes of Health)H-Index: 14
Last.Emily S. Finn (NIH: National Institutes of Health)H-Index: 15
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While inter-subject correlation (ISC) analysis is a powerful tool for naturalistic scanning data, drawing appropriate statistical inferences is difficult due to the daunting task of accounting for the intricate relatedness in data structure as well as the intricacy of handling the multiple testing issue. In our previous work we proposed nonparametric approaches to performing group ISC analysis through bootstrapping for one group of subjects and permutation testing for two groups (Chen et al., 20...
1 CitationsSource
#1Yinghua Yu (Okayama University)H-Index: 1
#2Laurentius HuberH-Index: 10
Last.Peter A. BandettiniH-Index: 73
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When humans perceive a sensation, their brains integrate inputs from sensory receptors and process them based on their expectations. The mechanisms of this predictive coding in the human somatosensory system are not fully understood. We fill a basic gap in our understanding of the predictive processing of somatosensation by examining the layer-specific activity in sensory input and predictive feedback in the human primary somatosensory cortex (S1). We acquired submillimeter functional magnetic r...
1 CitationsSource
#1Adam SteelH-Index: 6
#2Cibu ThomasH-Index: 15
Last.Chris I. BakerH-Index: 38
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Abstract Resting-state functional connectivity (rsFC) between brain regions has been used for studying training-related changes in brain function during the offline period of skill learning. However, it is difficult to infer whether the observed training-related changes in rsFC measured between two scans occur as a consequence of task performance, whether they are specific to a given task, or whether they reflect confounding factors such as diurnal fluctuations in brain physiology that impact th...
#1Gang Chen (HHS: United States Department of Health and Human Services)H-Index: 34
#2Robert W. Cox (HHS: United States Department of Health and Human Services)H-Index: 4
Last.Paul A. Taylor (HHS: United States Department of Health and Human Services)H-Index: 14
view all 6 authors...
10 CitationsSource