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Yves Menezo
Intelligence and National Security Alliance
EndocrinologyEmbryoBlastocystSpermBiology
269Publications
44H-index
7,772Citations
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Publications 264
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Resume Objectif: Les MTHFR SNPs, (Methylene-TetrahydroFolate-Reductase, Single nucleotide Polymorphisms) sont des isoformes qui affectent, jusqu’ a 75% l’activite de cette enzyme impliquee dans le cycle des folates, adosse au cycle de la methionine (Met). Ce cycle participe a la reparation de l’ADN, regule les reactions de methylation et regenere l’ homocysteine (Hcy). En biologie de la reproduction, la methylation joue un role majeur dans la gametogenese en regulant le maintien de l’epigenese e...
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Abstract Purpose Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5-MTHF), the active folate that allows the recycling of homocysteine (Hcy) to Methionine. Hcy is at the epicentre of oxidative stress and DNA methylation errors. This SNP often increases the circulating Hcy levels and consequently reduces the methylation process, which is involved in the epigenesis and imprinting of markings...
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#1Yves MenezoH-Index: 44
#2Brian DaleH-Index: 32
Last. Kay Elder (Bourn Hall Clinic)H-Index: 21
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3 CitationsSource
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#1Dominique CornetH-Index: 2
#2Arthur ClementH-Index: 1
Last. Yves MenezoH-Index: 44
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A 41-year-old Caucasian woman with a history of infertility dating from 2011 was identified as wild-type (no mutations) for methylenetetrahydrofolate reductase single nucleotide polymorphisms (MTHF...
1 CitationsSource
An increasing number of publications indicate that babies born after IVF (in vitro fertilization) procedures have higher rates of anomalies related to imprinting/epigenetic changes, which may be attributed to suboptimal culture conditions. Appropriate maintenance of DNA methylation during the first few days of an in vitro culture requires a supply of methyl donors, which are lacking in current in vitro culture systems. The absence of protection against oxidative stress in the culture increases t...
3 CitationsSource
3 CitationsSource
#1Arthur ClementH-Index: 1
#2Yves MenezoH-Index: 44
Last. Patrice ClementH-Index: 6
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Abstract Research question Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5-MTHF), the active folate that allows the recycling of homocysteine (Hcy) to methionine. Hcy is at the epicentre of oxidative stress and DNA methylation errors. This SNP often increases the circulating Hcy levels and consequently reduces the methylation process, which is involved in the epigenesis and imprinting o...
Source
#1Arthur ClementH-Index: 1
#2Dominique CornetH-Index: 2
Last. Yves MenezoH-Index: 44
view all 6 authors...
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#1Alessandra Gallo (Stazione Zoologica Anton Dohrn)H-Index: 9
#2Yves MenezoH-Index: 44
Last. Raffaele Boni (University of Basilicata)H-Index: 15
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The sperm plasma membrane is a sensitive target to oxidative stress. The most representative reactive oxygen species (ROS) scavengers in the genital tract, hypotaurine and glutathione, require, for their synthesis, cysteine whose availability is associated with the 1-carbon cycle (1-CC). Human, bovine and ascidian spermatozoa were incubated with compounds supporting the 1-CC (Vitamin B6, Methylcobalamin, 5 Methyl Tetrahydrofolate, Zinc Bisglycinate and N-acetyl-cysteine) (TRT) and compared to th...
2 CitationsSource
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