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Ji Li
University of Mississippi Medical Center
17Publications
6H-index
97Citations
Publications 17
Newest
#1Haiyan Hu (UMMC: University of Mississippi Medical Center)H-Index: 1
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ping Zhu (Southern Medical University)H-Index: 6
view all 9 authors...
Abstract Carvedilol, a third generation beta blocker, is in clinical use for heart failure patients. However, besides adrenergic receptor blockade, the pharmacological effects of carvedilol on cardiomyocytes remain unknown. AMP-activated protein kinase (AMPK) is an emerging target recognized for heart failure treatment. The mechanical properties and intracellular Ca 2+ properties were measured in isolated cardiomyocyte contractile functions in response to ischemic stress. Treatment of cardiomyoc...
#1Qingguo Lu (Sichuan University)H-Index: 1
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 8 authors...
Diabetics have higher morbidity and mortality in cardiovascular disease (CVD). A variety of antidiabetic agents are available for clinical choice. Cardiovascular (CV) safety assessment of these agents is crucial in addition to hypoglycemic effect before clinical prescription. Adenosine 5′-monophosphate-activated protein kinase (AMPK) is an important cell energy sensor, which plays an important role in regulating myocardial energy metabolism, reducing ischemia and ischemia/reperfusion (I/R) injur...
#1Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 9 authors...
#1Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 8 authors...
Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has continued to increase over the past decade. All cardiovascular diseases causing dysfunction of various physiological processes can result in HF. AMP-activated protein kinase (AMPK), an energy sensor, has pleiotropic cardioprotective effects and plays a critical role in the progression of HF. In this review, we highlight that AMPK can not only improve the energy supply in the failing heart by promoting ...
#1Xu Chen (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 10 authors...
Abstract Background AMP-activated Protein Kinase (AMPK) is a stress-activated kinase that protects against cardiomyocyte injury during ischemia and reperfusion. c-Jun N-terminal kinase (JNK), a mitogen activated protein kinase, is activated by ischemia and reperfusion. NF-κB is an important transcription factor involved in ischemia and reperfusion injury. Methods and Results The intrinsic activation of AMPK attenuates the inflammation which occurred during ischemia/reperfusion through the modula...
#1Lin Wang (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Nanhu Quan (UMMC: University of Mississippi Medical Center)H-Index: 5
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
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#1Courtney Cates (UMMC: University of Mississippi Medical Center)H-Index: 9
#2Thomas Rousselle (UMMC: University of Mississippi Medical Center)H-Index: 5
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
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Abstract We found that the anticoagulant plasma protease, activated protein C (APC), stimulates the energy sensor kinase, AMPK, in the stressed heart by activating protease-activated receptor 1 (PAR1) on cardiomyocytes. Wild-type (WT) and AMPK-kinase dead (KD) transgenic mice were subjected to transverse aortic constriction (TAC) surgery. The results demonstrated that while no phenotypic differences can be observed between WT and AMPK-KD mice under normal physiological conditions, AMPK-KD mice e...
#1Nanhu Quan (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Lin Wang (UMMC: University of Mississippi Medical Center)H-Index: 5
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
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Abstract We have revealed that a novel stress-inducible protein, Sestrin2, declines in the heart with aging. Moreover, there is an interaction between Sestrin2 and energy sensor AMPK in the heart in response to ischemic stress. The objective of this study is to determine whether Sestrin2-AMPK complex modulates PGC-1α in the heart and protects the heart from ischemic insults. In order to characterize the role of cardiac Sestrin2-AMPK signaling cascade in aging, C57BL/6 wild type young mice (3–4 m...
#1Ruiqi Feng (UMMC: University of Mississippi Medical Center)H-Index: 1
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 1
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 8 authors...
Abstract Ginsenosides have been studied extensively in recent years due to their therapeutic effects in cardiovascular diseases. While most studies examined the different ginsenosides individually, few studies compare the therapeutic effects among the different types. This study examined how effective protopanaxadiol, protopanaxatriol ginsenosides Rh2, Rg3, Rh1, and Rg2 of the ginsenoside family are in protecting H9c2 cardiomyocytes from damage caused by hypoxia/reoxygenation. In the current stu...
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