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Orison O. Woolcott
Cedars-Sinai Medical Center
28Publications
9H-index
233Citations
Publications 28
Newest
Published on Jun 25, 2019in American Journal of Physiology-endocrinology and Metabolism 4.13
Malini S. Iyer6
Estimated H-index: 6
(Cedars-Sinai Medical Center),
Rebecca L. Paszkiewicz4
Estimated H-index: 4
(Cedars-Sinai Medical Center)
+ 9 AuthorsCathryn M. Kolka15
Estimated H-index: 15
(Cedars-Sinai Medical Center)
CB1 receptor antagonism improves the deleterious effects of a high fat diet (HFD) by reducing body fat mass and adipocyte cell size. Previous studies demonstrated that the beneficial effects of the...
Published on Jun 1, 2019in Diabetes 7.20
Rebecca K. Paszkiewicz , Richard N. Bergman103
Estimated H-index: 103
+ 5 AuthorsMorvarid Kabir14
Estimated H-index: 14
We have previously demonstrated in dogs that following exposure to a high fat diet for 16 weeks, the brain and peripheral penetrating CB1R antagonist Rimonabant (RIM) promoted adipose tissue beiging and decreased adipocyte cell size. It is hoped that peripherally restricted CB1R antagonists, such as AM6545, will allow for the substantial beneficial metabolic effects of CB1R antagonism without the possible negative consequences associated with brain penetrance. Studies demonstrated beneficial met...
Published on Dec 1, 2018in Scientific Reports 4.01
Orison O. Woolcott9
Estimated H-index: 9
(Cedars-Sinai Medical Center),
Richard N. Bergman103
Estimated H-index: 103
(Cedars-Sinai Medical Center)
High whole-body fat percentage is independently associated with increased mortality. We aimed to identify a simple anthropometric linear equation that is more accurate than the body mass index (BMI) to estimate whole-body fat percentage among adult individuals. National Health and Nutrition Examination Survey (NHANES) 1999–2004 data (n = 12,581) were used for model development and NHANES 2005–2006 data (n = 3,456) were used for model validation. From the 365 anthropometric indices generated, the...
Isaac Asare-Bediako2
Estimated H-index: 2
(Cedars-Sinai Medical Center),
Rebecca L. Paszkiewicz4
Estimated H-index: 4
(Cedars-Sinai Medical Center)
+ 6 AuthorsRichard N. Bergman103
Estimated H-index: 103
(Cedars-Sinai Medical Center)
Hyperinsulinemia, accompanied by reduced first-pass hepatic insulin extraction (FPE) and increased secretion, is a primary response to insulin resistance. Different in vivo methods are used to esti...
Published on Aug 1, 2018in Diabetes 7.20
Isaac Asare-Bediako2
Estimated H-index: 2
(Cedars-Sinai Medical Center),
Rebecca L. Paszkiewicz4
Estimated H-index: 4
(Cedars-Sinai Medical Center)
+ 5 AuthorsRichard N. Bergman103
Estimated H-index: 103
(Cedars-Sinai Medical Center)
Although the β-cells secrete insulin, the liver, with its first-pass insulin extraction (FPE), regulates the amount of insulin allowed into circulation for action on target tissues. The metabolic clearance rate of insulin, of which FPE is the dominant component, is a major determinant of insulin sensitivity (SI). We studied the intricate relationship among FPE, SI, and fasting insulin. We used a direct method of measuring FPE, the paired portal/peripheral infusion protocol, where insulin is infu...
Published on May 1, 2018in Diabetes 7.20
Isaac Asare Bediako5
Estimated H-index: 5
,
Rebecca L. Paszkiewicz4
Estimated H-index: 4
+ 1 AuthorsRichard N. Bergman103
Estimated H-index: 103
The plasma concentration of insulin is determined by pancreatic beta cell secretion and the metabolic clearance of the hormone. It has been suggested that the concentration of insulin determines its metabolic clearance rate. Also, some reports suggest that clearance is saturable and insulin kinetics are non-linear even within physiologic ranges. We assessed the metabolic clearance rate of insulin at different physiologic concentrations to access if clearance changes with concentration. Using the...
Published on Oct 1, 2017in Current Diabetes Reports 4.00
Joyce M. Richey16
Estimated H-index: 16
(SC: University of Southern California),
Orison O. Woolcott9
Estimated H-index: 9
(Cedars-Sinai Medical Center)
Purpose of review The purpose of the review was to revisit the possibility of the endocannabinoid system being a therapeutic target for the treatment of obesity by focusing on the peripheral roles in regulating appetite and energy metabolism.
Published on Jul 17, 2017in Anales de la Facultad de Medicina
Oscar Castillo Sayán (UNMSM: National University of San Marcos), Orison O. Woolcott9
Estimated H-index: 9
(Cedars-Sinai Medical Center)
Obesity is considered an epidemic disease. It is a risk factor for diabetes mellitus type 2 and some other metabolic and neoplastic disorders. The national and worldwide prevalence of obesity at high altitude and the relation between obesity and chronic and acute hypoxia at high altitude are revised.
Published on Nov 1, 2016in Diabetes 7.20
Malini S. Iyer6
Estimated H-index: 6
(Cedars-Sinai Medical Center),
Richard N. Bergman103
Estimated H-index: 103
(Cedars-Sinai Medical Center)
+ 5 AuthorsCathryn M. Kolka15
Estimated H-index: 15
(Cedars-Sinai Medical Center)
Activation of the sympathetic nervous system (SNS) constitutes a putative mechanism of obesity-induced insulin resistance. Thus, we hypothesized that inhibiting the SNS by using renal denervation (RDN) will improve insulin sensitivity (S I ) in a nonhypertensive obese canine model. S I was measured using euglycemic-hyperinsulinemic clamp (EGC), before (week 0 [w0]) and after 6 weeks of high-fat diet (w6-HFD) feeding and after either RDN (HFD + RDN) or sham surgery (HFD + sham). As expected, HFD ...
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