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Orison O. Woolcott
Cedars-Sinai Medical Center
30Publications
10H-index
262Citations
Publications 31
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#1Orison O. Woolcott (Cedars-Sinai Medical Center)H-Index: 10
#2Richard N. Bergman (Cedars-Sinai Medical Center)H-Index: 96
We have recently proposed and validated a simple and accurate method to estimate whole-body fat percentage in adults, the relative fat mass (RFM), derived from the ratio of height to waist circumference. We aimed to identify RFM cutoffs to diagnose obesity based on the association between RFM and all-cause mortality. We used data from adult participants (≥20 years of age, n = 43,793) of the National Health and Nutrition Examination Survey (NHANES) 1999–2014 linked with death certificate records ...
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#1Orison O. Woolcott (Cedars-Sinai Medical Center)H-Index: 10
#2Richard N. Bergman (Cedars-Sinai Medical Center)H-Index: 96
We evaluated the ability of the Relative Fat Mass (RFM) to estimate whole-body fat percentage among children and adolescents who participated in the National Health and Nutrition Examination Survey from 1999 through 2006 (n = 10,390). The RFM equation for adults (64 − (20 × height/waist circumference) + (12 × sex)) may be used for adolescents 15 to 19 years of age. For children and adolescents 8 to 14 years of age, we suggest a modified RFM equation, named as the RFMp (RFM pediatric): 74 − (22 ×...
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#1Malini S. Iyer (Cedars-Sinai Medical Center)H-Index: 7
#2Rebecca L. Paszkiewicz (Cedars-Sinai Medical Center)H-Index: 5
Last.Morvarid Kabir (Cedars-Sinai Medical Center)H-Index: 14
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CB1 receptor (CB1R) antagonism improves the deleterious effects of a high-fat diet (HFD) by reducing body fat mass and adipocyte cell size. Previous studies demonstrated that the beneficial effects...
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We have previously demonstrated in dogs that following exposure to a high fat diet for 16 weeks, the brain and peripheral penetrating CB1R antagonist Rimonabant (RIM) promoted adipose tissue beiging and decreased adipocyte cell size. It is hoped that peripherally restricted CB1R antagonists, such as AM6545, will allow for the substantial beneficial metabolic effects of CB1R antagonism without the possible negative consequences associated with brain penetrance. Studies demonstrated beneficial met...
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#1Orison O. Woolcott (Cedars-Sinai Medical Center)H-Index: 10
#2Richard N. Bergman (Cedars-Sinai Medical Center)H-Index: 96
High whole-body fat percentage is independently associated with increased mortality. We aimed to identify a simple anthropometric linear equation that is more accurate than the body mass index (BMI) to estimate whole-body fat percentage among adult individuals. National Health and Nutrition Examination Survey (NHANES) 1999–2004 data (n = 12,581) were used for model development and NHANES 2005–2006 data (n = 3,456) were used for model validation. From the 365 anthropometric indices generated, the...
7 CitationsSource
#1Isaac Asare-Bediako (Cedars-Sinai Medical Center)H-Index: 3
#2Rebecca L. Paszkiewicz (Cedars-Sinai Medical Center)H-Index: 5
Last.Richard N. Bergman (Cedars-Sinai Medical Center)H-Index: 96
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Hyperinsulinemia, accompanied by reduced first-pass hepatic insulin extraction (FPE) and increased secretion, is a primary response to insulin resistance. Different in vivo methods are used to esti...
3 CitationsSource
#1Isaac Asare-Bediako (Cedars-Sinai Medical Center)H-Index: 3
#2Rebecca L. Paszkiewicz (Cedars-Sinai Medical Center)H-Index: 5
Last.Richard N. Bergman (Cedars-Sinai Medical Center)H-Index: 96
view all 8 authors...
Although the β-cells secrete insulin, the liver, with its first-pass insulin extraction (FPE), regulates the amount of insulin allowed into circulation for action on target tissues. The metabolic clearance rate of insulin, of which FPE is the dominant component, is a major determinant of insulin sensitivity (SI). We studied the intricate relationship among FPE, SI, and fasting insulin. We used a direct method of measuring FPE, the paired portal/peripheral infusion protocol, where insulin is infu...
5 CitationsSource
Last.Richard N. BergmanH-Index: 96
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The plasma concentration of insulin is determined by pancreatic beta cell secretion and the metabolic clearance of the hormone. It has been suggested that the concentration of insulin determines its metabolic clearance rate. Also, some reports suggest that clearance is saturable and insulin kinetics are non-linear even within physiologic ranges. We assessed the metabolic clearance rate of insulin at different physiologic concentrations to access if clearance changes with concentration. Using the...
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#2Richard N. BergmanH-Index: 96
Last.Morvarid KabirH-Index: 14
view all 8 authors...
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#1Joyce M. Richey (SC: University of Southern California)H-Index: 17
#2Orison O. Woolcott (Cedars-Sinai Medical Center)H-Index: 10
Purpose of review The purpose of the review was to revisit the possibility of the endocannabinoid system being a therapeutic target for the treatment of obesity by focusing on the peripheral roles in regulating appetite and energy metabolism.
12 CitationsSource
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