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Qianqian Ni
National Institutes of Health
ProdrugMolecular biologyNanoparticleMaterials scienceImmune system
11Publications
8H-index
225Citations
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Publications 13
Newest
#1Liangcan HeH-Index: 2
#2Qianqian NiH-Index: 8
Last. Yaya ChengH-Index: 2
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Biocatalytic reactions in living cells involve complex transformations in the spatially confined microenvironments. Inspired by biological transformation processes, we demonstrate effective biocata...
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#1Qianqian Ni (NU: Nanjing University)H-Index: 8
#2Fuwu Zhang (NIH: National Institutes of Health)H-Index: 23
Last. Guangming Lu (NU: Nanjing University)H-Index: 46
view all 12 authors...
Neoantigen vaccines have been enthusiastically pursued for personalized cancer immunotherapy while vast majority of neoantigens have no or low immunogenicity. Here, a bi-adjuvant neoantigen nanovaccine (banNV) that codelivered a peptide neoantigen (Adpgk) with two adjuvants [Toll-like receptor (TLR) 7/8 agonist R848 and TLR9 agonist CpG] was developed for potent cancer immunotherapy. Specifically, banNVs were prepared by a nanotemplated synthesis of concatemer CpG, nanocondensation with cationic...
1 CitationsSource
#1Guocan Yu (NIH: National Institutes of Health)H-Index: 35
#2Tian-Yong Cen (Hangzhou Normal University)H-Index: 2
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 16 authors...
2 CitationsSource
#1Qianqian Ni (NU: Nanjing University)H-Index: 8
#2Ngoc B. Pham (Duquesne University)H-Index: 1
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
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Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease affecting 3 million individuals in the U.S. The pathogenesis of T1DM is driven by immune-mediated destruction of pancreatic β cells, the source of glucose regulator insulin. While T1DM can be successfully managed with insulin replacement therapy, approaches that can modify the underlying immuno-pathology of β cell destruction has been long sought after. Immunotherapy can attenuate T cell responses against β cell antigens. Given th...
1 CitationsSource
#1Fuwu Zhang (NIH: National Institutes of Health)H-Index: 23
#2Qianqian Ni (NU: Nanjing University)H-Index: 8
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 14 authors...
16 CitationsSource
#1Qianqian Ni (NU: Nanjing University)H-Index: 8
#2Fuwu Zhang (NIH: National Institutes of Health)H-Index: 23
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 12 authors...
13 CitationsSource
#1Qianqian Ni (NU: Nanjing University)H-Index: 8
#2Fuwu Zhang (NIH: National Institutes of Health)H-Index: 23
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 12 authors...
Source
#1Yunlu Dai (Xidian University)H-Index: 36
#2Zhen Yang (NIH: National Institutes of Health)H-Index: 18
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
view all 16 authors...
39 CitationsSource
#1Yunlu DaiH-Index: 36
#2Siyuan ChengH-Index: 6
Last. Xiaoyuan ChenH-Index: 112
view all 14 authors...
This study applies in situ production of hypochlorous acid (HOCl) to improve the therapeutic efficacy of platinum drugs. The phagocytic enzyme myeloperoxidase (MPO) is coated with two functional polyphenol derivatives (platinum prodrug polyphenols and PEG polyphenols) and ferric ion by metal phenolic coordination, which can shield MPO from degradation by other compounds in the blood. Moreover, the platinum prodrug can be reduced to cisplatin in cells and produce hydrogen peroxide (H2O2). The MPO...
15 CitationsSource
#1Wei Chen (SYSU: Sun Yat-sen University)H-Index: 3
#2Rui Tian (Ha Tai: Xiamen University)H-Index: 11
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 112
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The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while...
19 CitationsSource
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