Mario E. Ruiz
University of Texas Health Science Center at San Antonio
Publications 6
#1Victor Kim (TU: Temple University)H-Index: 23
#2H. Zhao (TU: Temple University)H-Index: 4
Last.Mario E. RuizH-Index: 5
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Background Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown. Methods We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study wit...
1 CitationsSource
#1Jeong Yun (Harvard University)H-Index: 10
#2Andrew Lamb (Brigham and Women's Hospital)H-Index: 2
Last.R. Tal-SingerH-Index: 1
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Background Eosinophilic airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is associated with exacerbations and responsivity to steroids, suggesting potential shared mechanisms with eosinophilic asthma. However, there is no consistent blood eosinophil count that has been used to define the increased exacerbation risk. Objective We sought to investigate blood eosinophil counts associated with exacerbation risk in patients with COPD. Methods Blood eosinophil counts a...
14 CitationsSource
#1Adel Boueiz (Brigham and Women's Hospital)H-Index: 14
#2Yale Chang (NU: Northeastern University)H-Index: 7
Last.Mario E. RuizH-Index: 5
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Background Emphysema has considerable variability in its regional distribution. Craniocaudal emphysema distribution is an important predictor of the response to lung volume reduction. However, there is little consensus regarding how to define upper lobe-predominant and lower lobe-predominant emphysema subtypes. Consequently, the clinical and genetic associations with these subtypes are poorly characterized. Methods We sought to identify subgroups characterized by upper-lobe or lower-lobe emphyse...
7 CitationsSource
#1Brian D. Hobbs (Harvard University)H-Index: 10
#2Marilyn G. Foreman (Morehouse School of Medicine)H-Index: 25
Last.Michael J. Lane (UTSA: University of Texas at San Antonio)H-Index: 23
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Rationale: The demographic, physiological, and computed tomography (CT) features associated with pneumothorax in smokers with and without chronic obstructive pulmonary disease (COPD) are not clearly defined.Objectives: We evaluated the hypothesis that pneumothorax in smokers is associated with male sex, tall and thin stature, airflow obstruction, and increased total and subpleural emphysema.Methods: The study included smokers with and without COPD from the COPDGene Study, with quantitative chest...
8 CitationsSource
#1Carlos H. Martinez (UM: University of Michigan)H-Index: 14
#2Ya Hong Chen (PKU: Peking University)H-Index: 1
Last.Gregory L. Kinney (Colorado School of Public Health)H-Index: 30
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Background The value of quantitative CT (QCT) to identify chronic obstructive pulmonary disease (COPD) phenotypes is increasingly appreciated. The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George9s Respiratory Questionnaire (SGRQ) and Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index (BODE). Methods 1200 COPDGene subjects meeting Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria for COPD with QCT analysis we...
75 CitationsSource
#1Mateusz Siedlinski (Harvard University)H-Index: 4
#2Michael H. Cho (Harvard University)H-Index: 34
Last.Mario E. Ruiz (University of Texas Health Science Center at San Antonio)H-Index: 5
view all 93 authors...
Background Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and COPD severity. Previous genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) and a dopamine beta-hydroxylase (DBH) locus associated with smoking cessation in multiple populations. Objective To identify SNPs associated with lifetime average and current CPD, age at smoking initiation,...
81 CitationsSource