Sujata Mulekar
University of South Alabama
Publications 2
#1Yong B. TanH-Index: 1
#2Sujata Mulekar (USA: University of South Alabama)H-Index: 2
Last.Mark N. Gillespie (USA: University of South Alabama)H-Index: 30
view all 8 authors...
Lung ischemia-reperfusion (IR) injury contributes to post-transplant complications, including primary graft dysfunction. Decades of reports show that reactive oxygen species generated during lung IR contribute to pulmonary vascular endothelial barrier disruption and edema formation, but the specific target molecule(s) that “sense” injury-inducing oxidant stress to activate signaling pathways culminating in pathophysiologic changes have not been established. This review discusses evidence that mi...
4 CitationsSource
#1Jon D. Simmons (USA: University of South Alabama)H-Index: 12
#2Yann-Leei Lee (USA: University of South Alabama)H-Index: 3
Last.William O. Richards (USA: University of South Alabama)H-Index: 28
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Multiple organ dysfunction syndrome (MODS) is a common and potentially fatal consequence of severe injury. Although mitochondrial and bioenergetic dysfunction have been incriminated in the pathogenesis of MODS for many years,1–6 involvement of mitochondria-derived mediators may be more dynamic than previously appreciated. In this regard, fragments of the mitochondrial genome released into the circulation after injury—termed mtDNA damage-associated molecular patterns (DAMPs)—have been postulated ...
115 CitationsSource