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Thomas G. Bird
University of Glasgow
Progenitor cellLiver regenerationDiabetes mellitusMedicineBiology
63Publications
14H-index
1,364Citations
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Publications 55
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#1David M. Hughes (University of Liverpool)H-Index: 4
#2Sarah Berhane (University of Liverpool)H-Index: 11
Last. Toru KimuraH-Index: 17
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Abstract: Background & Aims Ultrasound (US)-based screening has been recommended for patients with an increased risk of hepatocellular Carcinoma (HCC). US analysis is, however, limited in patients who are obese or have small tumors. Addition of measurement of serum level of alpha-fetoprotein (AFP) to US analysis can increase detection of HCC. We analyzed data from patients with chronic liver disease, collected over 15 years in an HCC surveillance program, to develop a model to assess risk of HCC...
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#1Miryam MüllerH-Index: 1
#2Thomas G. Bird (Glas.: University of Glasgow)H-Index: 14
Last. Jean-Charles Nault (French Institute of Health and Medical Research)H-Index: 20
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Abstract Chronic liver disease and primary liver cancer are a massive global problem, with a future increase in incidences predicted. The most prevalent form of primary liver cancer, Hepatocellular carcinoma (HCC), occurs after years of chronic liver disease. Mutations in the genome are a causative and defining feature of all cancers. Chronic liver disease, mostly at the cirrhotic stage, causes the accumulation of progressive mutations which can drive cancer development. Within the liver a Darwi...
1 CitationsSource
#2Tianhui LiuH-Index: 1
Last. Xue LeiH-Index: 1
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Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable cell cycle arrest and a complex proinflammatory secretome, termed the senescence-associated secretory phenotype (SASP). We recently discovered that cytoplasmic chromatin fragments (CCFs), extruded from the nucleus of senescent cells, trigger the SASP through activation of the innate immunity cytosolic DNA sensing cGAS-STING pathway. However,...
5 CitationsSource
#1David BarberH-Index: 23
#2Mingtian ZhangH-Index: 1
Last. Thomas BirdH-Index: 2
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For distributions p and q with different support, the divergence generally will not exist. We define a spread divergence on modified p and q and describe sufficient conditions for the existence of such a divergence. We give examples of using a spread divergence to train implicit generative models, including linear models (Principal Components Analysis and Independent Components Analysis) and non-linear models (Deep Generative Networks).
1 Citations
#1Miryam MüllerH-Index: 1
#2Stuart J. Forbes (Edin.: University of Edinburgh)H-Index: 45
Last. Thomas G. Bird (Edin.: University of Edinburgh)H-Index: 14
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Chronic liver disease results in fibrosis and cancer. While injury is associated with mutational burden, a recent study (Zhu et al. Cell 2019;177:608–621) highlights that not all positively selected mutations in the liver are precancerous. Indeed, some may be beneficial to the ability of the liver to not only withstand injury , but also to regenerate.
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#1Ruben Amoros (Edin.: University of Edinburgh)H-Index: 1
#2Ruth King (Edin.: University of Edinburgh)H-Index: 23
Last. Thomas G. Bird (Edin.: University of Edinburgh)H-Index: 14
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Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer deaths worldwide, and its early detection is a critical determinant of whether curative treatment is achievable. Early stage HCC is typically asymptomatic. Thus, screening programmes are used for cancer detection in patients at risk of tumour development. Radiological screening methods are limited by imperfect data, cost and associated risks, and additionally are unable to detect lesions until they have grown to a certain s...
1 CitationsSource
#1Yee Voan Teo (Brown University)H-Index: 3
#2Nattaphong Rattanavirotkul (Edin.: University of Edinburgh)H-Index: 1
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
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Summary Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary endpoint marked by Notch activation. We find t...
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#2Rachel A. RidgwayH-Index: 29
#3Miryam MüllerH-Index: 1
Last. Owen J. SansomH-Index: 68
view all 12 authors...
The original version of this Article contained an error in the spelling of the author Miryam Muller, which was incorrectly given as Miryam Mueller. This has now been corrected in both the PDF and HTML versions of the Article.
1 Citations
#2Rachel A. RidgwayH-Index: 29
#3Miryam MüllerH-Index: 1
Last. Owen J. Sansom (Glas.: University of Glasgow)H-Index: 68
view all 12 authors...
The original version of this Article contained an error in the spelling of the author Miryam Muller, which was incorrectly given as Miryam Mueller. This has now been corrected in both the PDF and HTML versions of the Article.
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