Maria Grazia Vizioli
University of Glasgow
Cancer researchSenescenceThyroidChromatinBiology
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Publications 9
#2Tianhui LiuH-Index: 1
Last. Xue LeiH-Index: 1
view all 19 authors...
Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable cell cycle arrest and a complex proinflammatory secretome, termed the senescence-associated secretory phenotype (SASP). We recently discovered that cytoplasmic chromatin fragments (CCFs), extruded from the nucleus of senescent cells, trigger the SASP through activation of the innate immunity cytosolic DNA sensing cGAS-STING pathway. However,...
4 CitationsSource
Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and aggressive anaplastic carcinoma. Inflammation plays a critical role in thyroid tumors. Conditions predisposing to cancer, as well as oncogene activity, contribute to the construction of an inflammatory microenvironment that facilitates thyroid tumor progression. Moreover, oncogene-induced senescence, a mechanism tightly connected with infla...
2 CitationsSource
#1D PiscitelloH-Index: 1
#2D Varshney (Dund.: University of Dundee)H-Index: 1
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
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Deregulated AKT kinase activity due to PTEN deficiency in cancer cells contributes to oncogenesis by incompletely understood mechanisms. Here, we show that PTEN deletion in HCT116 and DLD1 colon carcinoma cells leads to suppression of CHK1 and CHK2 activation in response to irradiation, impaired G2 checkpoint proficiency and radiosensitization. These defects are associated with reduced expression of MRE11, RAD50 and NBS1, components of the apical MRE11/RAD50/NBS1 (MRN) DNA damage response comple...
10 CitationsSource
#1Zhixun Dou (UPenn: University of Pennsylvania)H-Index: 15
#2Kanad Ghosh (UPenn: University of Pennsylvania)H-Index: 3
Last. Shelley L. Berger (UPenn: University of Pennsylvania)H-Index: 86
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Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.
152 CitationsSource
#1Maria Grazia Vizioli (Glas.: University of Glasgow)H-Index: 6
#2Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
Summary: Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of senescent cells in vitro and in vivo . Their results could be useful in the design of novel therapies to treat aging-related diseases, including cancer. Cancer Discov; 6(6...
1 CitationsSource
#1M. Daniel Ricketts (UPenn: University of Pennsylvania)H-Index: 6
#2Brian Frederick (Wistar Institute)H-Index: 1
Last. Ronen Marmorstein (UPenn: University of Pennsylvania)H-Index: 56
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Histone chaperones bind specific histones to mediate their storage, eviction or deposition from/or into chromatin. The HIRA histone chaperone complex, composed of HIRA, ubinuclein-1 (UBN1) and CABIN1, cooperates with the histone chaperone ASF1a to mediate H3.3-specific binding and chromatin deposition. Here we demonstrate that the conserved UBN1 Hpc2-related domain (HRD) is a novel H3.3-specific-binding domain. Biochemical and biophysical studies show the UBN1-HRD preferentially binds H3.3/H4 ov...
47 CitationsSource
#1Taranjit Singh Rai (Glas.: University of Glasgow)H-Index: 18
#2John J. Cole (Glas.: University of Glasgow)H-Index: 7
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
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Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular senescence and associated tumor suppression depend on control of chromatin. Histone chaperone HIRA deposits variant histone H3.3 and histone H4 into chromatin in a DNA replication-independent manner. Appropriately for a DNA replication-independent chaperone, HIRA is involved in control of chromatin in nonproliferating senescent cells, although its role is poorly defined. Here, we show that nonproliferati...
46 CitationsSource
#2Marialuisa SensiH-Index: 23
Last. Angela GrecoH-Index: 39
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Papillary thyroid carcinoma (PTC) arises from the thyroid follicular epithelium and represents the most frequent thyroid malignancy. PTC is associated with gene rearrangements generating RET/PTC and TRK oncogenes, and to the BRAFV600E activating point mutation. A role of tumor-suppressor genes in the pathogenesis of PTC has not been assessed yet. The tissue inhibitor of metalloproteinase-3 (TIMP3) gene, encoding a metalloproteinases inhibitor and capable of inhibiting growth, angiogenesis, invas...
45 CitationsSource
#2Marialuisa SensiH-Index: 23
Last. Angela GrecoH-Index: 39
view all 8 authors...
Insulin-like growth factor-binding protein 7 (IGFBP7) is a secreted protein involved in several cellular processes, including proliferation, senescence and apoptosis. Loss of IGFBP7 expression is a critical step in the development of human tumors, including melanoma and colon cancer. By microarray gene expression studies, we have detected downregulation of IGFBP7 gene expression in follicular and papillary thyroid tumors in comparison with normal thyroid tissue. Evaluation of publicly available ...
60 CitationsSource