Match!
Kousho Wakae
Kyoto University
Molecular biologyP300-CBP Transcription FactorsHistoneChromatinBiology
2Publications
2H-index
28Citations
What is this?
Publications 2
Newest
#1Shuji Sakamoto (Kyoto University)H-Index: 3
#2Kousho Wakae (Kyoto University)H-Index: 2
Last. Yasutoshi AgataH-Index: 19
view all 14 authors...
V(D)J recombination of Ig and TCR genes is strictly regulated in a lineage- and stage-specific manner by the accessibility of target gene chromatin to the recombinases RAG1 and RAG2. It has been shown that enforced expression of the basic helix–loop–helix protein, E2A, together with RAG1/2 in a nonlymphoid cell line BOSC23 can induce V(D)J recombination in endogenous Igκ and TCR loci by increasing chromatin accessibility of target gene segments. In this study, we demonstrate that ectopically exp...
22 CitationsSource
#1Masatoshi NozakiH-Index: 12
#2Kousho Wakae (Kyoto University)H-Index: 2
Last. Yasutoshi Agata (Kyoto University)H-Index: 19
view all 9 authors...
V(D)J recombination of Ig and TCR genes is strictly regulated by the accessibility of target gene chromatin in a lineage- and stage-specific manner. In the mouse TCRg locus, rearrangement of the Vg2 gene predominates over Vg3 rearrangement in the adult thymus. This preferential rearrangement is likely due to the differential accessibility of the individual Vg genes, because the levels of germ line transcription and histone acetylation of the Vg genes are well correlated with the rearrangement fr...
4 CitationsSource
1