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Hui Zhang
Emory University
DNA repairMolecular biologySIRT2BiologyCell biology
22Publications
9H-index
264Citations
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Publications 23
Newest
#1Allyson E. Koyen (Emory University)H-Index: 3
#2Matthew Z. Madden (Emory University)H-Index: 4
Last. Jie Xu (Emory University)
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Small cell lung cancer (SCLC) is a highly aggressive malignancy with poor outcomes associated with resistance to cisplatin-based chemotherapy. Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2), which silences transcription through trimethylation of histone H3 lysine 27 (H3K27me3) and has emerged as an important therapeutic target with inhibitors targeting its methyltransferase activity under clinical investigation. Here, we show that EZH2 has a n...
Source
#1Hui Zhang (Emory University)H-Index: 9
#2PamelaSara E. Head (Emory University)H-Index: 4
Last. David S. Yu (Emory University)H-Index: 20
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The DNA damage response (DDR) is a signaling network that recognizes damages to DNA and orchestrates a variety of DNA repair and cell cycle checkpoint pathways. The DDR is pivotal for cancer prevention. Ataxia Telangiectasia And Rad3-Related Protein (ATR), a protein kinase, functions as an essential transducer of the DDR signaling cascade. ATR primarily responds to single-stranded DNA (ssDNA) generated from double-strand break resection or at stalled replication forks. Depletion of ATR leads to ...
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#1PamelaSara E. Head (Emory University)H-Index: 4
#2Nagaraju P. Ganji (Emory University)
Last. David S. Yu (Emory University)H-Index: 20
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DNA-dependent protein kinase (DNA-PK) plays a critical role in non-homologous end joining (NHEJ), the predominant pathway that repairs DNA double-strand breaks (DSB) in response to ionizing radiation (IR) to govern genome integrity. How DNA-PK is activated in response to DSBs has remained elusive. Here, we show that the SIRT2 sirtuin deacetylase and tumor suppressor directs the activation of DNA-PK through deacetylation of its catalytic subunit (DNA-PKcs). SIRT2 deacetylase activity governs cell...
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#1Elizabeth MintenH-Index: 1
#2Hui ZhangH-Index: 9
Last. David S. YuH-Index: 20
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#1Ashley J. Schlafstein (Emory University)H-Index: 1
#2Allison E. Withers (Emory University)H-Index: 2
Last. David S. Yu (Emory University)H-Index: 20
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Failure to achieve pathologic complete response is associated with poor prognosis in breast cancer patients following neoadjuvant chemotherapy (NACT). However, prognostic biomarkers for clinical outcome are unclear in this patient population. Cyclin-dependent kinase 9 (CDK9) is often dysregulated in breast cancer, and its deficiency results in genomic instability. We reviewed the records of 84 breast cancer patients from Emory University’s Winship Cancer Institute who had undergone surgical rese...
1 CitationsSource
#1James L. KloskyH-Index: 23
#2Vicky LehmannH-Index: 9
Last. Leslie R. Schover (University of Texas at Austin)H-Index: 4
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3 CitationsSource
#1Elizabeth MintenH-Index: 1
#2Hui ZhangH-Index: 9
Last. David S. YuH-Index: 20
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#1David S. YuH-Index: 20
#2Waaqo DaddachaH-Index: 3
Last. Baek KimH-Index: 35
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Source
#1PamelaSara E. Head (Emory University)H-Index: 4
#2Hui Zhang (Emory University)H-Index: 9
Last. David S. Yu (Emory University)H-Index: 20
view all 3 authors...
DNA Damage Response (DDR) pathways, including DNA repair and cell-cycle checkpoints, are critical for maintaining genome integrity and preventing disease including cancer. Deficiencies in the DDR result in increased susceptibility to cancer, a leading cause of morbidity and mortality worldwide. However, the mechanisms mediating the activities of the DDR and how their dysregulation leads to genomic instability and a tumor-permissive phenotype are not fully understood. Sirtuin 2 (SIRT2) is a class...
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#1James L. KloskyH-Index: 23
#2Fang WangH-Index: 2
Last. Leslie R. Schover (University of Texas MD Anderson Cancer Center)H-Index: 49
view all 15 authors...
PurposeTo estimate the prevalence of sperm banking among adolescent males newly diagnosed with cancer and to identify factors associated with banking outcomes.Patients and MethodsA prospective, single-group, observational study design was used to test the contribution of sociodemographic, medical, psychological/health belief, communication, and developmental factors to fertility preservation outcomes. At-risk adolescent males (N = 146; age 13.00 to 21.99 years; Tanner stage ≥ 3), their parents, ...
16 CitationsSource
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