Match!
Deborah Argaud
Laval University
7Publications
2H-index
31Citations
Publications 7
Newest
#1Deborah Argaud (Laval University)H-Index: 2
#2Marie-Chloé Boulanger (Laval University)H-Index: 17
Last.Patrick Mathieu (Laval University)H-Index: 48
view all 5 authors...
Source
#1R. Mickael (Laval University)
#2Marie-Chloé Boulanger (Laval University)H-Index: 17
Last.Patrick Mathieu (Laval University)H-Index: 48
view all 12 authors...
Introduction Calcific aortic valve stenosis (CAVS) is the most common heart valve disorder. Genome and transcriptome-wide association studies identified risk variant rs6702619 at the PALMD locus as casually associated with CAVS and with lower PALMD expression. Objective To map and fine-grain molecular analyses to probe the regulation and function of PALMD. Methods Regulation of the PALMD risk locus and its impact on valve interstitial cells (VICs) were evaluated. Reporter assays, DNA-binding ass...
Source
#1Ghada Mkannez (Laval University)H-Index: 3
#2Deborah Argaud (Laval University)H-Index: 2
Last.Patrick Mathieu (Laval University)H-Index: 48
view all 4 authors...
The aortic valve is a dynamic structure composed of valve interstitial cells (VICs) and valve endothelial cells (VECs), which contribute to maintain and repair the extracellular matrix (ECM). Disorders of the aortic valve, such as calcific aortic valve disease (CAVD), are characterized by the re-expression of embryonic genes involved in valvulogenesis and actively participate to the pathologic remodeling of the ECM. Studies performed in the last several years have underlined that inflammation an...
Source
#1Ghada Mkannez (Laval University)H-Index: 3
#2Valérie Gagné-Ouellet (Université de Sherbrooke)H-Index: 5
Last.Patrick Mathieu (Laval University)H-Index: 48
view all 12 authors...
4 CitationsSource
Source
Source
#1Mohamed Jalloul Nsaibia (Laval University)H-Index: 6
#2Marie-Chloé Boulanger (Laval University)H-Index: 17
Last.Patrick Mathieu (Laval University)H-Index: 48
view all 14 authors...
Abstract Oxidatively modified lipoproteins may promote the development/progression of calcific aortic valve stenosis (CAVS). Oxidative transformation of low-density lipoprotein (OxLDL) generates lysophosphatidic acid (LPA), a lipid mediator that accumulates in mineralized aortic valves. LPA activates at least 6 different G protein-coupled receptors, which may play a role in the pathophysiology of CAVS. We hypothesized that LPA derived from OxLDL may promote a NF-κB signature that drives osteogen...
27 CitationsSource
1