J. Patrick Cleary
Harvard University
Poly ADP ribose polymeraseGeneticsDNAPolymeraseBiology
What is this?
Publications 2
#1Jacob V. Layer (Harvard University)H-Index: 3
#2J. Patrick Cleary (Harvard University)H-Index: 2
Last. Tovah A. Day (Harvard University)H-Index: 7
view all 18 authors...
Chromosomal rearrangements, including translocations, are early and essential events in the formation of many tumors. Previous studies that defined the genetic requirements for rearrangement formation have identified differences between murine and human cells, most notably in the role of classic and alternative nonhomologous end-joining (NHEJ) factors. We reported that poly(ADP)ribose polymerase 3 (PARP3) promotes chromosomal rearrangements induced by endonucleases in multiple human cell types. ...
2 CitationsSource
#1Tovah A. Day (Harvard University)H-Index: 7
#2Jacob V. Layer (Harvard University)H-Index: 3
Last. David M. Weinstock (Harvard University)H-Index: 44
view all 14 authors...
Chromosomal rearrangements are essential events in the pathogenesis of both malignant and nonmalignant disorders, yet the factors affecting their formation are incompletely understood. Here we develop a zinc-finger nuclease translocation reporter and screen for factors that modulate rearrangements in human cells. We identify UBC9 and RAD50 as suppressors and 53BP1, DDB1 and poly(ADP)ribose polymerase 3 (PARP3) as promoters of chromosomal rearrangements across human cell types. We focus on PARP3 ...
12 CitationsSource