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Weili Zhang
Peking Union Medical College
47Publications
17H-index
874Citations
Publications 47
Newest
#1Junsong Gong (Peking Union Medical College)
#2Junsong Gong (Peking Union Medical College)
Last.Jia Shi (Peking Union Medical College)H-Index: 2
view all 10 authors...
Background In this study, we aimed to investigate whether and how lncRNA CASC2 was involved in hypoxia-induced pulmonary hypertension (PH)-related vascular remodeling.
#1Cunjin Wu (Tianjin Medical University)
#2Yibo Wang (Peking Union Medical College)H-Index: 17
Last.Rutai Hui (Peking Union Medical College)H-Index: 22
view all 6 authors...
ABSTRACTThe prevalence and associated risk factors of apparent treatment-resistant hypertension (aTRH) in older people in China is unknown. The aim of this study is to investigate the prevalence of aTRH in older people and describe the characteristics of older patients with aTRH. Using two-stage random clustering sampling, 3774 patients with hypertension aged ≥60–75 years were recruited between July 2012 and December 2015. The patients were divided into two groups: aTRH and non-aTRH groups accor...
#1Congrui Feng (Peking Union Medical College)H-Index: 2
#2Yunyun Yang (Peking Union Medical College)
Last.Weili Zhang (Peking Union Medical College)H-Index: 17
view all 8 authors...
#1Tao Kong (Peking Union Medical College)
#2Jingzhou Chen (Peking Union Medical College)H-Index: 14
Last.Rutai Hui (Peking Union Medical College)H-Index: 22
view all 8 authors...
#1Shujun Yang (Peking Union Medical College)H-Index: 3
#2Jian Li (Peking Union Medical College)H-Index: 1
Last.Rutai Hui (Peking Union Medical College)H-Index: 22
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Abstract Macrophages exhibit heterogeneity and plasticity and imbalance between pro-inflammatory and anti-inflammatory macrophages plays a critical role in atherosclerosis progression. Telomerase reverse transcriptase (TERT) in macrophages can be activated by nuclear factor-kappa B (NF-κB), but the regulation of telomerase activation on macrophages polarization remains unknown. We previously identified microRNA-216a (miR-216a) to promote inflammation through directly targeting the Smad3/NF-κB pa...
#1Chenghui Zhou (Peking Union Medical College)
#2Yu Chen (Peking Union Medical College)
Last.Jia Shi (Peking Union Medical College)H-Index: 2
view all 9 authors...
Abstract Objective To analyze the effects of miR-455-3p-1 and its possible mechanisms in pulmonary arterial hypertension (PAH). Methods A microarray assay was used to examine the expressed genes between normal and PAH. The expressed genes in PAH was assessed by qRT-PCR. The targeted interaction between miRNAs and FGF7 was confirmed using a dual luciferase reporter assay. A CCK-8 assay and cell count were used to analyze the pulmonary artery smooth muscle cells (PASMCs) activity and proliferation...
#1Rongxia Li (Peking Union Medical College)
#2Xuenan Mi (Peking Union Medical College)H-Index: 2
Last.Weili Zhang (Peking Union Medical College)H-Index: 17
view all 8 authors...
Abstract The role of angiotensin II (Ang II) in hypertension has been clarified, but recent studies show that aging-associated arterial changes and those with hypertension as well as atherosclerosis may have some common pathogenesis. This study aimed to clarify the effects of Ang II on endothelial senescence by establishing a replicative senescence model of human umbilical vein endothelial cells (HUVECs) in vitro . The population-doubling level (PDL) was calculated, PDL5 and PDL25 respectively r...
#1Jing LiH-Index: 1
#2Congrui Feng (Capital Medical University)H-Index: 2
Last.Weili Zhang (Peking Union Medical College)H-Index: 17
view all 9 authors...
The relationship between telomere length and stroke was inconsistent mostly due to different pathogenesis of subtypes, environment and genetics. We aimed to assess whether leukocyte telomere contributes to stroke in Southern Chinese by investigating a case-control study comprising 543 cases (224 atherothrombotic stroke, 94 hemorrhagic stroke and 225 lacunar infraction) and 616 controls and replicated the investigation in an independent study comprising 773 cases and 875 controls with the same di...
#1Shujun Yang (Peking Union Medical College)H-Index: 3
#2Xuenan Mi (Peking Union Medical College)H-Index: 2
Last.Weili Zhang (Capital Medical University)H-Index: 17
view all 7 authors...
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