Weili Zhang
Peking Union Medical College
44Publications
17H-index
861Citations
Publications 44
Newest
Published on May 1, 2019in Experimental Gerontology 3.22
Rongxia Li (Peking Union Medical College), Xuenan Mi2
Estimated H-index: 2
(Peking Union Medical College)
+ 5 AuthorsWeili Zhang17
Estimated H-index: 17
(Peking Union Medical College)
Abstract The role of angiotensin II (Ang II) in hypertension has been clarified, but recent studies show that aging-associated arterial changes and those with hypertension as well as atherosclerosis may have some common pathogenesis. This study aimed to clarify the effects of Ang II on endothelial senescence by establishing a replicative senescence model of human umbilical vein endothelial cells (HUVECs) in vitro . The population-doubling level (PDL) was calculated, PDL5 and PDL25 respectively r...
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Published on May 1, 2018in Journal of Cellular and Molecular Medicine 4.30
Shujun Yang2
Estimated H-index: 2
(Peking Union Medical College),
Xuenan Mi2
Estimated H-index: 2
(Peking Union Medical College)
+ 4 AuthorsWeili Zhang17
Estimated H-index: 17
(Capital Medical University)
4 Citations Source Cite
Published on Dec 1, 2018in Scientific Reports 4.12
Jing Li1
Estimated H-index: 1
,
Congrui Feng2
Estimated H-index: 2
(Capital Medical University)
+ 5 AuthorsWeili Zhang17
Estimated H-index: 17
(Peking Union Medical College)
The relationship between telomere length and stroke was inconsistent mostly due to different pathogenesis of subtypes, environment and genetics. We aimed to assess whether leukocyte telomere contributes to stroke in Southern Chinese by investigating a case-control study comprising 543 cases (224 atherothrombotic stroke, 94 hemorrhagic stroke and 225 lacunar infraction) and 616 controls and replicated the investigation in an independent study comprising 773 cases and 875 controls with the same di...
2 Citations Source Cite
Published on Jun 1, 2018in Biochimica et Biophysica Acta 3.44
Shujun Yang2
Estimated H-index: 2
(Peking Union Medical College),
Jian Li1
Estimated H-index: 1
(Peking Union Medical College)
+ 8 AuthorsBin Lv9
Estimated H-index: 9
(Peking Union Medical College)
Abstract Macrophages exhibit heterogeneity and plasticity and imbalance between pro-inflammatory and anti-inflammatory macrophages plays a critical role in atherosclerosis progression. Telomerase reverse transcriptase (TERT) in macrophages can be activated by nuclear factor-kappa B (NF-κB), but the regulation of telomerase activation on macrophages polarization remains unknown. We previously identified microRNA-216a (miR-216a) to promote inflammation through directly targeting the Smad3/NF-κB pa...
2 Citations Source Cite
Published on Dec 4, 2018in Clinical and Experimental Hypertension 1.37
Cunjin Wu (Tianjin Medical University), Yibo Wang17
Estimated H-index: 17
(Peking Union Medical College)
+ 3 AuthorsRutai Hui22
Estimated H-index: 22
(Peking Union Medical College)
ABSTRACTThe prevalence and associated risk factors of apparent treatment-resistant hypertension (aTRH) in older people in China is unknown. The aim of this study is to investigate the prevalence of aTRH in older people and describe the characteristics of older patients with aTRH. Using two-stage random clustering sampling, 3774 patients with hypertension aged ≥60–75 years were recruited between July 2012 and December 2015. The patients were divided into two groups: aTRH and non-aTRH groups accor...
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Published on Jan 1, 2017in Archives of Medical Science 2.34
Wenlong Li4
Estimated H-index: 4
,
Bi Huang7
Estimated H-index: 7
+ 7 AuthorsXiaohan Fan11
Estimated H-index: 11
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Published on Nov 11, 2016in Circulation 18.88
Shujun Yang2
Estimated H-index: 2
,
Jian Li1
Estimated H-index: 1
+ 2 AuthorsWeili Zhang17
Estimated H-index: 17
Background: The monocyte/macrophage is a central participant in the inflammatory process that is involved in all stages of atherosclerosis. Our previous work showed that telomerase reverse transcriptase (TERT) expression was particularly observed in the macrophage-rich region of atherosclerotic lesions. Interestingly, we have identified that miR-216a was remarkably up-regulated in macrophages differentiation, paralleling with the increased expression of TERT. In the present study, we aimed to ex...
Published on Jun 1, 2014in The American Journal of the Medical Sciences 1.77
Tao Tian6
Estimated H-index: 6
(Peking Union Medical College),
Yilu Wang10
Estimated H-index: 10
(Peking Union Medical College)
+ 8 AuthorsXianliang Zhou19
Estimated H-index: 19
(Peking Union Medical College)
Abstract Background The prognostic significance of myocardial bridging in hypertrophic cardiomyopathy (HCM) remains controversial. This investigation sought to evaluate the impact of myocardial bridging on prognosis of patients with HCM. Methods A total of 298 adult patients (73% male, mean age, 53 ± 12 years) with HCM were retrospectively enrolled at Fuwai Hospital from 1999 to 2011. Myocardial bridging was evaluated by coronary angiography. Follow-up data were collected by telephone interviews...
4 Citations Source Cite
Published on Oct 1, 2013in International Journal of Cardiology 4.03
Jingyao Fan3
Estimated H-index: 3
(Peking Union Medical College),
Yiqing Song3
Estimated H-index: 3
(Peking University)
+ 2 AuthorsWeili Zhang17
Estimated H-index: 17
(Peking Union Medical College)
Abstract Background Cardiovascular risk is inconsistent in the normal-weight, overweight, and obese individuals due to metabolic abnormality. We aimed to investigate combined effects of obesity and metabolic abnormality on the risk of cardiovascular disease and mortality. Methods The MEDLINE, EMBASE, Cochrane library, and references of relevant original articles prior to May 2013 were searched for prospective studies investigating cardiovascular risk and death associated with combined effects of...
109 Citations Source Cite
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