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Wei Peng
Chongqing Medical University
9Publications
4H-index
41Citations
Publications 9
Newest
#1Jianlin Zhao (CQMU: Chongqing Medical University)
#2Wei Peng (CQMU: Chongqing Medical University)H-Index: 4
Last.Hongbo Qi (CQMU: Chongqing Medical University)H-Index: 12
view all 8 authors...
Preeclampsia (PE) is a hypertensive disease associated with increased endothelial cell dysfunction caused by systemic oxidative stress. Alpha-actinin-4 (ACTN4) is a member of the α-actinin family of actin crosslinking proteins that are upregulated in several types of cancer. However, its role in PE remains unclear. In this study, we found that ACTN4 was localized in placenta vascular endothelial cells (ECs), and its expression was downregulated in primary human umbilical vein endothelial cells (...
1 CitationsSource
#1Yamin Liu (CQMU: Chongqing Medical University)H-Index: 2
#2Ting-Li Han (CQMU: Chongqing Medical University)H-Index: 9
Last.Hongbo Qi (CQMU: Chongqing Medical University)H-Index: 12
view all 10 authors...
Abstract Preeclampsia is characterized by new onset of hypertension and proteinuria after 20 weeks' gestation and is a leading cause of maternal and neonatal morbidity and mortality. The pathogenesis of preeclampsia is often associated with aberrant trophoblast function that leads to shallow placental implantation. However, the exact underlying mechanisms remain unclear. Placental LncZBTB39-1:2 expression level was investigated in 20 healthy placentae and 20 placentae with preeclampsia using qRT...
1 CitationsSource
#1Haiying Rao (CQMU: Chongqing Medical University)H-Index: 2
#2Yuxiang Bai (CQMU: Chongqing Medical University)H-Index: 2
Last.Hongbo Qi (CQMU: Chongqing Medical University)H-Index: 12
view all 11 authors...
2 CitationsSource
#1Xuehai ChenH-Index: 2
#2Chao TongH-Index: 9
Last.Hongbo QiH-Index: 12
view all 16 authors...
Normal placentation and a successful pregnancy depend on appropriate trophoblast cell migration and invasion. Inadequate trophoblast invasion and impaired spiral artery remodeling may lead to pregnancy-related disorders, such as preeclampsia. RPS4Y1 (ribosomal protein S4, Y-linked 1) is a member of the S4E family of ribosomal proteins. In this study, we found that RPS4Y1 levels were upregulated in placental samples collected from preeclamptic patients, when compared with the normotensive pregnan...
2 CitationsSource
#1Xuehai ChenH-Index: 2
#2Chao TongH-Index: 9
Last.Hongbo QiH-Index: 12
view all 16 authors...
Normal placentation and a successful pregnancy depend on appropriate trophoblast cell migration and invasion. Inadequate trophoblast invasion and impaired spiral artery remodeling may lead to pregn...
2 CitationsSource
#1Ying Chen (CQMU: Chongqing Medical University)H-Index: 6
#2Yi Zhang (National Health and Family Planning Commission)H-Index: 3
Last.Hongbo Qi (CQMU: Chongqing Medical University)H-Index: 12
view all 10 authors...
AbstractObjective: Wnt5a and Wnt signaling play potential roles in human placental and fetal development. The objective of this study is to explore the role of Wnt5a in the invasion of the human trophoblast cell line HTR8/SVneo and the probable mechanism of early placentation and preeclampsia in which Wnt5a is involved.Methods: Human first trimester villous tissues from normal pregnancies and third trimester placentas from pregnancies with or without preeclampsia (PE) were used in the detection ...
11 CitationsSource
#1Ying Chen (CQMU: Chongqing Medical University)H-Index: 6
#2Yi Zhang (National Health and Family Planning Commission)H-Index: 3
Last.Hongbo Qi (CQMU: Chongqing Medical University)H-Index: 12
view all 10 authors...
Placentation is a complicated process critical for maternal–fetal exchange of nutrients and gases that includes stepwise vasculogenesis and angiogenesis. Wnt inhibitory factor 1 (WIF1) is a secreted Wnt antagonist that acts as a tumor-suppressor gene by antagonizing angiogenesis and proliferation and inducing apoptosis. The purpose of this study was to investigate the function of WIF1 on placental angiogenesis in human umbilical vein endothelial cells (HUVECs) under hypoxic conditions. We found ...
5 CitationsSource
#1Wei Peng (CQMU: Chongqing Medical University)H-Index: 4
#2Ying Chen (CQMU: Chongqing Medical University)H-Index: 6
Last.Hongbo Qi (CQMU: Chongqing Medical University)H-Index: 12
view all 9 authors...
Abstract Introduction The invasion of extravillous cytotrophoblasts (EVTs) into the maternal uterine decidua and vasculature is critical for human placenta development and pregnancy maintenance. The imprinted gene MEST/PEG1 has been implicated in trophoblast development; however, the role of MEST in EVT invasion and the accompanying early pregnancy complications are not fully understood. Methods Western blot, immunofluorescence and immunohistochemistry were used to detect MEST protein expression...
8 CitationsSource
#1Nan Shan (CQMU: Chongqing Medical University)H-Index: 8
#2Xuemei Zhang (CQMU: Chongqing Medical University)H-Index: 5
Last.Hongbo Qi (CQMU: Chongqing Medical University)H-Index: 12
view all 10 authors...
Preeclampsia (PE) is associated with defective placental angiogenesis and poor placentation. Laminins are the main noncollagenous glycoproteins in basement membranes, and laminin α4 (LAMA4) promotes the migration, proliferation, and survival of various cells. The primary purpose of this study is to investigate the role of LAMA4 in human umbilical vein endothelial cells (HUVECs) function during the development of PE. We found expression levels of LAMA4 in human PE placentas were significantly low...
10 CitationsSource
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