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Jeong Su Park
Yonsei University
19Publications
7H-index
121Citations
Publications 19
Newest
#1Jeong Su Park (Yonsei University)H-Index: 7
#2Yu Seol Lee (Yonsei University)H-Index: 3
Last.Soo Han Bae (Yonsei University)H-Index: 17
view all 4 authors...
Abstract Nonalcoholic steatohepatitis (NASH) is a common liver disease associated with metabolic disorders, including obesity and type 2 diabetes (T2D). Despite its worldwide prevalence, there are no effective drugs for the treatment of NASH. The progression of NASH is mainly accelerated by reactive oxygen species (ROS)-induced lipotoxicity. The transcription factor known as nuclear factor erythroid 2-related factor 2 (Nrf2) is pivotal for the elimination of ROS. Accordingly, activators of Nrf2 ...
#1Jung Bok Lee (Yonsei University)H-Index: 19
#2Jeong Su Park (Yonsei University)H-Index: 7
Last.Hak-Joon Sung (Yonsei University)H-Index: 21
view all 10 authors...
#1Jeong Su Park (Yonsei University)H-Index: 7
#2Da Hyun Lee (Yonsei University)H-Index: 6
Last.Soo Han Bae (Yonsei University)H-Index: 17
view all 8 authors...
ABSTRACTSaturated fatty acid (SFA)-induced lipotoxicity is caused by the accumulation of reactive oxygen species (ROS), which is associated with damaged mitochondria. Moreover, lipotoxicity is cruc...
#1Yu Seol Lee (Yonsei University)H-Index: 3
#2Jeong Su Park (Yonsei University)H-Index: 7
Last.Soo Han Bae (Yonsei University)H-Index: 17
view all 7 authors...
Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder closely linked with type II diabetes (T2D). The progression of NAFLD is associated with the induction of lipogenesis through hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) pathway. An increase in lipogenesis induces endoplasmic reticulum (ER) stress and accelerates oxidative liver injury in the pathogenesis of NAFLD. Lobeglitazone, one of thiazolidinedione (TZDs), is used as an antidiabetic drug to lower ...
#1Sora HanH-Index: 7
#2Ae Lee Jeong (Sookmyung Women's University)H-Index: 8
Last.Young YangH-Index: 21
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Rationale: Circulating CTRP1 (C1q/TNF-α [tumor necrosis factor-α]–related protein 1) levels are increased in hypertensive patients compared with those in healthy subjects. Nonetheless, little is kn...
#1Hyo Jeong YongH-Index: 1
#2Jeong Su ParkH-Index: 7
Last.Young YangH-Index: 21
view all 15 authors...
// Hyo Jeong Yong 1 , Jeong Su Park 2 , Ae Lee Jeong 1 , Sora Han 1 , Sunyi Lee 1 , Hye In Ka 1 , Buyanravjkh Sumiyasuren 1 , Hyun Jeong Joo 1 , Su Jeong So 1 , Ji Young Park 1 , Do-Young Yoon 3 , Jong-Seok Lim 1 , Myeong-Seok Lee 1 , Hee Gu Lee 4 and Young Yang 1 1 Department of Biological Sciences, Sookmyung Women’s University, Seoul, Republic of Korea 2 Department of Severance Biomedical Science Institute, Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul, Kor...
#1Jeong Su Park (Yonsei University)H-Index: 7
#2Sue Young Oh (Yonsei University)H-Index: 3
Last.Soo Han Bae (Yonsei University)H-Index: 17
view all 10 authors...
AbstractEndoplasmic reticulum (ER) stress is triggered by various cellular stresses that disturb protein folding or calcium homeostasis in the ER. To cope with these stresses, ER stress activates the unfolded protein response (UPR) pathway, but unresolved ER stress induces reactive oxygen species (ROS) accumulation leading to apoptotic cell death. However, the mechanisms that underlie protection from ER stress-induced cell death are not clearly defined. The nuclear factor erythroid 2-related fac...
#1Da Hyun Lee (Yonsei University)H-Index: 6
#2Dai Hoon Han (Yonsei University)H-Index: 3
Last.Soo Han Bae (Yonsei University)H-Index: 17
view all 21 authors...
Abstract Oxidative stress is important for the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a chronic disease that ranges from hepatic steatosis to nonalcoholic steatohepatitis (NASH). The nuclear factor erythroid 2-related factor 2–Kelch-like ECH associated protein 1 (Nrf2-Keap1) pathway is essential for cytoprotection against oxidative stress. In this study, we found that oxidative stress or inflammatory biomarkers and TUNEL positive cells were markedly increased in NASH patients ...
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