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Ronald Ng
Yale University
DesmoplakinCardiomyopathyBiochemistryBioinformaticsBiology
9Publications
1H-index
2Citations
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Publications 10
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#1Ronald Ng (Yale University)H-Index: 1
#2Lorenzo R. Sewanan (Yale University)H-Index: 2
Last. Stuart G. Campbell (Yale University)H-Index: 13
view all 8 authors...
Engineered heart tissues (EHTs) have emerged as a robust in vitro model to study cardiac physiology. Although biomimetic culture environments have been developed to better approximate in vivo conditions, currently available methods do not permit full recapitulation of the four phases of the cardiac cycle. We have developed a bioreactor which allows EHTs to undergo cyclic loading sequences that mimic in vivo work loops. EHTs cultured under these working conditions exhibited enhanced concentric co...
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#1Jinkyu Park (Yale University)H-Index: 2
Last. Yibing QyangH-Index: 21
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Abstract Single ventricle heart defects (SVDs) are congenital disorders that result in a variety of complications, including increased ventricular mechanical strain and mixing of oxygenated and deoxygenated blood, leading to heart failure without surgical intervention. Corrective surgery for SVDs are traditionally handled by the Fontan procedure, requiring a vascular conduit for completion. Although effective, current conduits are limited by their inability to aid in pumping blood into the pulmo...
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#1Lorenzo R. Sewanan (Yale University)H-Index: 2
#2Shi Shen (Yale University)
Last. Stuart G. Campbell (Yale University)H-Index: 13
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#1Ronald NgH-Index: 1
#2Heather R. ManringH-Index: 3
Last. Stuart G. CampbellH-Index: 13
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2 CitationsSource
#1Tyler L. StevensH-Index: 1
#2Heather R. ManringH-Index: 3
Last. Maegen A. AckermannH-Index: 11
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#1Maegen A. Ackermann (OSU: Ohio State University)H-Index: 11
#2Heather R. Manring (OSU: Ohio State University)H-Index: 3
Last. Stuart G. Campbell (Yale University)H-Index: 13
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#1Ronald NgH-Index: 1
#2Xia LiH-Index: 2
Last. Stuart G. CampbellH-Index: 13
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#1Heather R. ManringH-Index: 3
#2Ronald NgH-Index: 1
Last. Maegen A. AckermannH-Index: 11
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#1Jeffery A. Clark (Yale University)
#2Ronald Ng (Yale University)H-Index: 1
Last. Stuart G. Campbell (Yale University)H-Index: 13
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Recent advances have shown the importance of electrical stimulation in enhancing maturation and differentiation of engineered heart tissues (EHTs). Conventional electrical maturation protocols pace their EHTs with field stimulation - the tissues are paced simultaneously in a uniform electrical field. This method has been shown to improve cellular alignment, increase contractility, and increase gap junction (Cx43) production. While Cx43 production is increased, the anisotropic ratio is not fully ...
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