Ronald Ng
Yale University
Publications 6
#1Jinkyu Park (Yale University)H-Index: 1
Last.Ronald Ng (Yale University)
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Abstract Single ventricle heart defects (SVDs) are congenital disorders that result in a variety of complications, including increased ventricular mechanical strain and mixing of oxygenated and deoxygenated blood, leading to heart failure without surgical intervention. Corrective surgery for SVDs are traditionally handled by the Fontan procedure, requiring a vascular conduit for completion. Although effective, current conduits are limited by their inability to aid in pumping blood into the pulmo...
#1Maegen A. Ackermann (OSU: Ohio State University)H-Index: 11
#2Heather R. Manring (OSU: Ohio State University)H-Index: 2
Last.Nathan T. Wright (JMU: James Madison University)H-Index: 11
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#1Jeffery A. Clark (Yale University)
#2Ronald Ng (Yale University)
Last.Stuart G. Campbell (Yale University)H-Index: 13
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Recent advances have shown the importance of electrical stimulation in enhancing maturation and differentiation of engineered heart tissues (EHTs). Conventional electrical maturation protocols pace their EHTs with field stimulation - the tissues are paced simultaneously in a uniform electrical field. This method has been shown to improve cellular alignment, increase contractility, and increase gap junction (Cx43) production. While Cx43 production is increased, the anisotropic ratio is not fully ...