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Jaime Bosch
University of Alberta
CirrhosisPortal hypertensionPortal venous pressureMedicineGastroenterology
12Publications
1H-index
8Citations
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Publications 21
Newest
#1Vincenzo La Mura (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 17
#2Càndid Villanueva (Hospital de Sant Pau)H-Index: 29
Last. Jaime Bosch (U of A: University of Alberta)
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We thank Kumar and colleagues for their interest in our new algorithm for risk-stratification in candidates to secondary prophylaxis of variceal bleeding. In this algorithm, patients that bleed without other manifestations of hepatic decompensation are classified as low-risk without measuring the hepatic venous pressure gradient (HVPG). Using our new algorithm, a large number of invasive and costly HVPG measurements can be saved. More importantly, the number of high-risk patients who did not reb...
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#1A. BerzigottiH-Index: 4
#2Jaime BoschH-Index: 1
#1Ivan Amat-RoldanH-Index: 1
#2A. BerzigottiH-Index: 4
Last. Jaime BoschH-Index: 1
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#1Andrea Ribeiro de Souza (Ciber)H-Index: 1
#2Vincenzo La MuraH-Index: 17
Last. Jaime Bosch (Ciber)H-Index: 1
view all 9 authors...
Background & Aims Patients who have their first episode of variceal bleeding despite primary prophylaxis with a nonselective β-adrenergic receptor antagonist (also called a nonselective β-blocker [NSBB]) receive additional treatment by endoscopic band ligation to prevent further bleeding. However, little is known about their long-term outcomes. Methods We collected data on 89 consecutive patients with cirrhosis who were admitted to the Liver Unit of Hospital Clinic, Barcelona, with acute esophag...
18 CitationsSource
#1Enric ReverterH-Index: 14
#2Susana SeijoH-Index: 20
Last. Jaime BoschH-Index: 1
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PPHT is defined as pulmonary arterial hypertension (PAH) associ-ated with portal hypertension, with or without hepatic disease, but it most commonly occurs in the setting of cirrhosis. Portal hypertension, rather than the presence of underlying liver disease, appears to be the main deter-mining factor for the development of PAH.
#1Andrea De GottardiH-Index: 20
#2A. BerzigottiH-Index: 4
Last. Jaime BoschH-Index: 1
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Background: In cirrhosis, hepatic endothelial dysfunction as a result of oxidative stress contributes to the postprandial increase in hepatic venous pressure gradient (HVPG). Objective: We aimed at testing the hypothesis that dark chocolate, which holds potent antioxidant properties, might attenuate the postprandial increase in HVPG in patients with cirrhosis. Design: In this phase 2, double-blind, controlled study, 22 cirrhotic patients referred for HVPG measurement were included and randomly a...
1 Citations
#1Vincenzo La MuraH-Index: 17
#2Juan Carlos Reverter (University of Barcelona)H-Index: 21
Last. Juan Carlos García-Pagán (Ciber)H-Index: 79
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Background and aims Endothelial dysfunction is a major determinant of the increased hepatic vascular tone of cirrhotic livers. Von Willebrand factor (vWF), P-selectin and 8-iso-PGF2α (isoprostanes), surrogate markers of endothelial dysfunction, are increased in patients with cirrhosis. This study was aimed at exploring in patients with cirrhosis and portal hypertension the relation of these endothelial factors with systemic and hepatic haemodynamics and their possible clinical prognostic value. ...
74 CitationsSource
#1Susana Seijo-RíosH-Index: 1
#2Puneeta TandonH-Index: 1
Last. Juan C. García-PagánH-Index: 15
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The Budd-Chiari syndrome (BCS) is an uncommon and life-threatening disorder defined as the obstruction of hepatic venous outflow regardless of its causative mechanism or level of obstruction. The clinical presentation of BCS is highly variable and can range from asymptomatic cases to fulminant hepatic failure with encephalopathy. In the vast majority of cases, it is possible to identify an inherited or acquired prothrombotic risk factor as the underlying cause of thrombosis being chronic myelopr...
#1Juan G. Abraldes (University of Barcelona)H-Index: 57
#2Jaime BoschH-Index: 1
Last. Juan C. García-PagánH-Index: 15
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Variceal bleeding is one of the most common and severe complications of cirrhosis. Even with the current best medical care, mortality from variceal bleeding is still around 15–20%. Moreover, variceal bleeding often leads to deterioration in liver function, and it is a common trigger for other complications of cirrhosis, such as bacterial infections or hepatorenal syndrome.
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#1Gautam Mehta (UCL: University College London)H-Index: 9
Last. Jaime BoschH-Index: 1
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The splanchnic and hepatic circulations account for over a quarter of cardiac output and are highly specialized to meet the demands of these complex and complementary organs. The hepatic circulation is fundamental to liver function, and the splanchnic circulation participates in the control of systemic hemodynamics as well as perfusion of the intestine.
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