James R. White
Johns Hopkins University School of Medicine
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Publications 16
#1Valsamo AnagnostouH-Index: 22
#2Daniel C. Bruhm (Johns Hopkins University)H-Index: 4
Last. Joseph Murray (Johns Hopkins University)H-Index: 13
view all 20 authors...
#1Valsamo Anagnostou (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 22
#2Noushin Niknafs (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 15
Last. Victor VelculescuH-Index: 2
view all 35 authors...
Despite progress in immunotherapy, identifying patients that respond has remained a challenge. Through analysis of whole-exome and targeted sequence data from 5,449 tumors, we found a significant correlation between tumor mutation burden (TMB) and tumor purity, suggesting that low tumor purity tumors are likely to have inaccurate TMB estimates. We developed a new method to estimate a corrected TMB (cTMB) that was adjusted for tumor purity and more accurately predicted outcome to immune checkpoin...
6 CitationsSource
Last. Siân JonesH-Index: 37
view all 25 authors...
#1Stephen Cristiano (Johns Hopkins University)H-Index: 4
#2Alessandro Leal (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
Last. Victor E. Velculescu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 93
view all 36 authors...
Cell-free DNA in the blood provides a non-invasive diagnostic avenue for patients with cancer1. However, characteristics of the origins and molecular features of cell-free DNA are poorly understood. Here we developed an approach to evaluate fragmentation patterns of cell-free DNA across the genome, and found that profiles of healthy individuals reflected nucleosomal patterns of white blood cells, whereas patients with cancer had altered fragmentation profiles. We used this method to analyse the ...
17 CitationsSource
#1Valsamo Anagnostou (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 22
#2Patrick M. Forde (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
Last. Victor E. Velculescu (Johns Hopkins University)H-Index: 93
view all 36 authors...
Despite the initial successes of immunotherapy, there is an urgent clinical need for molecular assays that identify patients more likely to respond. Here, we report that ultrasensitive measures of circulating tumor DNA (ctDNA) and T-cell expansion can be used to assess responses to immune checkpoint blockade in metastatic lung cancer patients ( N = 24). Patients with clinical response to therapy had a complete reduction in ctDNA levels after initiation of therapy, whereas nonresponders had no si...
8 CitationsSource
#1Eniko Papp (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 7
#2Dorothy Hallberg (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
Last. Robert B. Scharpf (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 21
view all 18 authors...
Summary To improve our understanding of ovarian cancer, we performed genome-wide analyses of 45 ovarian cancer cell lines. Given the challenges of genomic analyses of tumors without matched normal samples, we developed approaches for detection of somatic sequence and structural changes and integrated these with epigenetic and expression alterations. Alterations not previously implicated in ovarian cancer included amplification or overexpression of ASXL1 and H3F3B, deletion or underexpression of ...
7 CitationsSource
#1Filipa Godoy-Vitorino (Interamerican University of Puerto Rico)H-Index: 10
#2Josefina Romaguera (UPR: University of Puerto Rico)H-Index: 11
Last. Martin J. Blaser (NYU: New York University)H-Index: 133
view all 13 authors...
The human cervicovaginal microbiota resides at an interface between the host and the environment and may affect susceptibility to disease. Puerto Rican women have high HPV infection and cervical cancer rates. We hypothesized that the population structure of the cervicovaginal bacterial and fungal biota changed with cervical squamous intraepithelial lesions and HPV infections. DNA was extracted from cervix, introitus and anal sites of 62 patients attending high-risk San Juan clinics. The 16S rRNA...
4 CitationsSource
#1Karen S. Sfanos (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 21
#2Mark C. MarkowskiH-Index: 8
Last. Ashley E. Ross (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 32
view all 8 authors...
It is well known that the gastrointestinal (GI) microbiota can influence the metabolism, pharmacokinetics, and toxicity of cancer therapies. Conversely, the effect of cancer treatments on the composition of the GI microbiota is poorly understood. We hypothesized that oral androgen receptor axis-targeted therapies (ATT), including bicalutamide, enzalutamide, and abiraterone acetate, may be associated with compositional differences in the GI microbiota. We profiled the fecal microbiota in a cross-...
10 CitationsSource
#1Patrick M. Forde (Johns Hopkins University)H-Index: 17
#2Jamie E. Chaft (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 29
Last. Drew M. Pardoll (Johns Hopkins University)H-Index: 116
view all 35 authors...
Background: Programmed death-1 (PD-1) blocking antibodies improve survival in patients with advanced non-small-cell lung cancer (NSCLC) but have not been tested in resectable NSCLC, where little progress has been made over the last decade. Methods: Adults with untreated surgically resectable stage I-IIIA NSCLC received two doses of nivolumab (anti-PD-1) preoperatively. The primary endpoints of the study were safety and feasibility. Tumor pathologic response, PD-L1 expression, mutation burden and...
1 CitationsSource
#1Karim Boudadi (Johns Hopkins University)H-Index: 5
#2Daniel L. Suzman (FDA: Food and Drug Administration)H-Index: 9
Last. Emmanuel S. AntonarakisH-Index: 29
view all 28 authors...
// Karim Boudadi 1 , Daniel L. Suzman 4 , Valsamo Anagnostou 1 , Wei Fu 1 , Brandon Luber 1 , Hao Wang 1 , Noushin Niknafs 1 , James R. White 1 , John L. Silberstein 3 , Rana Sullivan 1 , Donna Dowling 1 , Rana Harb 1 , Thomas R. Nirschl 1 , Brendan A. Veeneman 5, 9 , Scott A. Tomlins 5, 6 , Yipeng Wang 7 , Adam Jendrisak 7 , Ryon P. Graf 7 , Ryan Dittamore 7 , Michael A. Carducci 1 , Mario A. Eisenberger 1 , Michael C. Haffner 2 , Alan K. Meeker 2 , James R. Eshleman 2 , Jun Luo 3 , Victor E. V...
15 CitationsSource