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Lizelle Zandberg
North-West University
Prospective cohort studyFibrinogenDiabetes mellitusMedicineBiology
8Publications
3H-index
35Citations
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Publications 10
Newest
#1Tanja Barth-Jaeggi (University of Basel)H-Index: 2
#2Lizelle Zandberg (NWU: North-West University)H-Index: 3
Last. Kaspar Wyss (University of Basel)H-Index: 21
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1 CitationsSource
#1Jacomina P. du Plessis (NWU: North-West University)
#2Alida Melse-Boonstra (NWU: North-West University)H-Index: 22
Last. Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 5
view all 4 authors...
Abstract Background Elevated homocysteine (Hcy) is associated with several pathologies. Gene–diet interactions related to Hcy might be used to customize dietary advice to reduce disease incidence. To explore this possibility, we investigated interactions between anthropometry, biochemical markers and diet and single-nucleotide polymorphisms (SNPs) in relation to Hcy concentrations. Five SNPs of Hcy-metabolizing enzymes were analyzed in 2010 black South Africans. Results Hcy was higher with each ...
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Last. Cornelius M. SmutsH-Index: 15
view all 7 authors...
Background Recent studies are suggesting a U-shaped relationship between antenatal iron exposure and birth outcomes. Little is known about the iron status and associated birth outcomes of pregnant women in South Africa. Our aim was to assess iron status at early, mid- and late pregnancy, and to determine associations with gestational age and birth weight in women in Johannesburg, South Africa.
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#1Aletta E. Schutte (South African Medical Research Council)H-Index: 44
#2Philimon N. Gona (University of Massachusetts Boston)H-Index: 21
Last. Hugo W. Huisman (South African Medical Research Council)H-Index: 24
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BackgroundGlobally hypertension is stabilising, but in sub-Saharan Africa the incidence of hypertension remains on an increase. Although this might be attributed to poor healthcare and ineffective ...
3 CitationsSource
#1Elizabeth A. Symington (NWU: North-West University)H-Index: 2
#2Jeannine Baumgartner (NWU: North-West University)H-Index: 12
Last. Cornelius M. Smuts (NWU: North-West University)H-Index: 15
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Background Adequate nutrition during pregnancy is important to ensure optimal birth outcomes, maternal health and offspring development. However, little is known about the dietary intake and nutritional status of pregnant women residing in urban South Africa. Therefore, the Nutrition during Pregnancy and Early Development (NuPED) cohort study was initiated to assess early nutrition-related exposures predictive of early childhood development in urban South Africa.
2 CitationsSource
#1H. Toinét Cronjé (NWU: North-West University)H-Index: 1
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 5
Last. Marlien Pieters (NWU: North-West University)H-Index: 16
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Interleukin-6 (IL-6) induces the expression of fibrinogen, and polymorphic variation within the fibrinogen genes is believed to alter the magnitude of this expression. The identification of the functional relevance of individual fibrinogen single nucleotide polymorphisms (SNPs) has been hindered by the high linkage disequilibrium (LD) reported in the European fibrinogen gene locus. This study investigated two novel and 12 known fibrinogen SNPs of potential functional relevance, in 2010 Tswana in...
1 CitationsSource
#1H. Toinét Cronjé (NWU: North-West University)H-Index: 1
#2Cornelie Nienaber-Rousseau (NWU: North-West University)H-Index: 5
Last. Marlien Pieters (NWU: North-West University)H-Index: 16
view all 7 authors...
Abstract Fibrinogen and its functional aspects have been linked to cardiovascular disease. There is vast discrepancy between the heritability of fibrinogen concentrations observed in twin studies and the heritability uncovered by genome wide association studies. We postulate that some of the missing heritability might be explained by the pleiotropic and polygenic co-regulation of fibrinogen through multiple targeted genes, apart from the fibrinogen genes themselves. To this end we investigated s...
2 CitationsSource
#1Johannes F. Wentzel (NWU: North-West University)H-Index: 8
#2Karen E Charlton (NWU: North-West University)H-Index: 49
Last. Lizelle Zandberg (NWU: North-West University)H-Index: 3
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Mycotoxins are toxic secondary metabolites produced by a range of fungi and are common contaminants of agricultural crops. These toxins are chemically diverse and structurally stable, enabling them to enter the food chain which can lead to numerous adverse health effects in animals and humans. Although mycotoxin exposure is associated with the development of several cancers, it has proved challenging to show a direct connection between exposure and oncogenic change. This study investigates the i...
24 CitationsSource
#1L. Malan (NWU: North-West University)H-Index: 7
#2Jeannine Baumgartner (NWU: North-West University)H-Index: 12
Last. Cornelius M. Smuts (NWU: North-West University)H-Index: 15
view all 5 authors...
We recently reported that iron supplementation increased respiratory morbidity in iron deficient South African children. This increase, however, was attenuated when iron was provided in combination with a mixture of DHA/EPA. To explore potential underlying mechanisms, we examined the effects of iron and DHA/EPA, alone and in combination, on plasma lipid-derived immune modulator concentrations and related gene expression in peripheral blood mononuclear cells (PBMC). DHA/EPA decreased inflammatory...
3 CitationsSource
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