Sue Young Oh
Yonsei University
Publications 3
#1Jeong Su Park (Yonsei University)H-Index: 7
#2Sue Young Oh (Yonsei University)H-Index: 3
Last.Soo Han Bae (Yonsei University)H-Index: 17
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AbstractEndoplasmic reticulum (ER) stress is triggered by various cellular stresses that disturb protein folding or calcium homeostasis in the ER. To cope with these stresses, ER stress activates the unfolded protein response (UPR) pathway, but unresolved ER stress induces reactive oxygen species (ROS) accumulation leading to apoptotic cell death. However, the mechanisms that underlie protection from ER stress-induced cell death are not clearly defined. The nuclear factor erythroid 2-related fac...
9 CitationsSource
#1Soo Han Bae (Ewha Womans University)H-Index: 17
#2Su Haeng Sung (Ewha Womans University)H-Index: 8
Last.Sue Goo Rhee (Ewha Womans University)H-Index: 100
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Summary Sestrins (Sesns) protect cells from oxidative stress. The mechanism underlying the antioxidant effect of Sesns has remained unknown, however. The Nrf2-Keap1 pathway provides cellular defense against oxidative stress by controlling the expression of antioxidant enzymes. We now show that Sesn1 and Sesn2 interact with the Nrf2 suppressor Keap1, the autophagy substrate p62, and the ubiquitin ligase Rbx1 and that the antioxidant function of Sesns is mediated through activation of Nrf2 in a ma...
201 CitationsSource
#1Soo Han BaeH-Index: 17
#2Su Haeng SungH-Index: 8
Last.Sue Goo RheeH-Index: 100
view all 9 authors...
Abstract Aims: To define the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress. Results: Pyrazole increased Srx expression in the liver of mice in a nuclear factor erythroid 2–related factor 2 (Nrf2)-dependent manner and induced Srx translocation from the cytosol to the endoplasmic reticulum (ER) and mitochondria. Pyrazole also induced the expression of CYP2E1, a primary reactive oxygen species (ROS...
27 CitationsSource