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Pi-I D. Lin
Harvard University
Prospective cohort studyPregnancyGestationDiabetes mellitusMedicine
14Publications
2H-index
17Citations
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Publications 19
Newest
#1Sharia M. AhmedH-Index: 8
#2Adam J. BranscumH-Index: 15
Last. Golam MostofaH-Index: 11
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#1Pi-I D. Lin (Harvard University)H-Index: 2
#2Andres Cardenas (University of California, Berkeley)H-Index: 1
Last. Emily Oken (Harvard University)H-Index: 60
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Abstract The relationship of plasma concentration of per- and polyfluoroalkyl substances (PFAS) with blood pressure (BP) is uncertain. This study examined cross-sectional and prospective associations of PFAS with BP and hypertension. We quantified plasma PFAS concentrations from 957 participants enrolled in the lifestyle and placebo arms of the Diabetes Prevention Program (DPP), a randomized controlled trial with approximately 15 years of follow-up. We used multivariable linear and logistic regr...
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#1Pi-I D. Lin (Harvard University)H-Index: 2
#2Andres Cardenas (University of California, Berkeley)H-Index: 1
Last. Citlalli Osorio-Yáñez (UNAM: National Autonomous University of Mexico)
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Abstract Diet is assumed to be the main source of exposure to per- and polyfluoroalkyl substances (PFAS) in non-occupationally exposed populations, but studies on the diet-PFAS relationship in the United States are scarce. We extracted multiple dietary variables, including daily intakes of food group, diet scores, and dietary patterns, from self-reported dietary data collected at baseline (1996–1999) from adults with pre-diabetes enrolled in the Diabetes Prevention Program, and used linear regre...
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PCORnet, the Patient-Centered Outcomes Research Network, is comprised of health systems and health plans that transform electronic health records (EHRs) and claims data to a common data model (CDM)...
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#1Shangzhi Gao (Harvard University)H-Index: 1
#2Pi-I D. Lin (Harvard University)H-Index: 2
Last. David C. Christiani (Harvard University)H-Index: 1
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Background Prenatal inorganic arsenic (iAs) exposure is associated with pregnancy outcomes. Maternal capabilities of arsenic biotransformation and elimination may influence the susceptibility of arsenic toxicity. Therefore, we examined the determinants of arsenic metabolism of pregnant women in Bangladesh who are exposed to high levels of arsenic.
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#1Sengwee Toh (Harvard University)H-Index: 28
#4Bailey Lc (Children's Hospital of Philadelphia)H-Index: 1
Last. Jason P. Block (Harvard University)H-Index: 17
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Privacy-protecting analytic approaches without centralized pooling of individual-level data, such as distributed regression, are particularly important for vulnerable populations, such as children, but these methods have not yet been tested in multi-center pediatric studies. Using the electronic health data from 34 healthcare institutions in the National Patient-Centered Clinical Research Network (PCORnet), we fit 12 multivariable-adjusted linear regression models to assess the associations of a...
1 CitationsSource
#1Pi-I D. Lin (Harvard University)H-Index: 2
#2Andres Cardenas (University of California, Berkeley)H-Index: 1
Last. Emily Oken (Harvard University)H-Index: 60
view all 11 authors...
Abstract Exposure to per- and polyfluoroalkyl substances (PFASs) may interfere with lipid regulation. However, most previous studies were cross-sectional with the risk of reverse causation, suggesting a need for long-term prospective studies. We examined the relationship of baseline plasma PFAS concentrations with repeated measures of blood lipids. We included 888 prediabetic adults from the Diabetes Prevention Program (DPP) and DPP Outcomes Study, who had measurements of 6 plasma PFAS concentra...
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#1Andrés Cárdenas (University of California, Berkeley)H-Index: 31
#2Marie-France Hivert (Harvard University)H-Index: 38
Last. Emily Oken (Harvard University)H-Index: 60
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OBJECTIVE Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are suspected endocrine disruptors widely detected across populations. We examine the extent to which PFASs are associated with diabetes incidence and microvascular disease. Secondarily, we tested whether a lifestyle intervention modifies associations and decreases concentrations. RESEARCH DESIGN AND METHODS We analyzed data from a prospective cohort of 957 participants from the Diabetes Prevention Program (DPP) trial and Diabetes P...
1 CitationsSource
#1Pi-I D. Lin (Harvard University)H-Index: 2
#2Andres Cardenas (University of California, Berkeley)H-Index: 1
Last. Emily Oken (Harvard University)H-Index: 60
view all 12 authors...
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#1Pi-I D. Lin (Harvard University)H-Index: 2
#2Matthew F. Daley (KP: Kaiser Permanente)H-Index: 32
Last. Jason P. Block (Harvard University)H-Index: 17
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Researchers often use prescribing data from electronic health records (EHR) or dispensing data from medication or medical claims to determine medication utilization. However, neither source has complete information on medication use. We compared antibiotic prescribing and dispensing records for 200,395 patients in the National Patient-Centered Clinical Research Network (PCORnet) Antibiotics and Childhood Growth Study. We stratified analyses by delivery system type [closed integrated (cIDS) and n...
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