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Lei Shi
Tongji University
37Publications
7H-index
279Citations
Publications 37
Newest
Abstract Background 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) is a reliable treatment for actinic keratosis (AK), and the concentration of ALA for this treatment is 20% in most studies, but it was found that 10% ALA could achieve similar outcome during clinical practice while reducing the costs. However, there are limited reports comparing the efficacy and the safety of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) with different ALA doses. Objectives This...
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#1Chunxiao Li (Tongji University)
#2Lehang Guo (Tongji University)H-Index: 1
Last.Xiuli Wang (Tongji University)H-Index: 11
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Abstract Extramammary Paget’s disease (EMPD) is a rare intraepithelial neoplasm arising in apocrine rich area of the skin. Surgery is the standard treatment but relapse is common. The postoperative skin defects, penile reconstruction, functional effects and old age are also challenges for curing disease. Herein, a case of postoperative recurrent EMPD, which was treated by combination therapy of non-invasive repeatable ALA-PDT and deep penetrated holmium laser is reported. Ultrasonography monitor...
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#1Lei Shi (Tongji University)H-Index: 7
#2Pei Liu (Tongji University)H-Index: 2
Last.Xiuli Wang (Tongji University)H-Index: 11
view all 10 authors...
Aim: To clarify the effectiveness and safety of x-ray-activated photodynamic therapy (X-PDT) for cutaneous squamous cell carcinoma (SCC) and melanoma. Materials & methods: Copper-cysteamine nanopar...
2 CitationsSource
#1Zhe Zheng (YZU: Yangzhou University)
#2Linglin Zhang (Tongji University)H-Index: 10
Last.Xiuli Wang (Tongji University)H-Index: 11
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Abstract Background To date, it has been reported that the intrinsic factors(lesions location, lesions area, disease tynpes) and extrinsic factors(fluence rate) contribute to the pain during 5-aminolevulinic acid photodynamic therapy (ALA-PDT). But there are few studies on pain during ALA-PDT and lack of sufficient clinical evidence related to the pain intensity. Objective To investigate pain intensity and its relative factors during ALA-PDT and to provide clinical implication. Methods The pain ...
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#1Peiru Wang (Tongji University)H-Index: 6
#2Linglin Zhang (Tongji University)H-Index: 10
Last.Xiuli Wang (Tongji University)H-Index: 11
view all 6 authors...
ABSTRACTIntense pulsed light (IPL) is a good option for erythema and telangiectasia of rosacea. Demodex, which is light and heat sensitive, is an important risk of Rosacea. Sometimes, IPL can induce rosacea aggravation. Here, we show two cases of erythema rosacea aggravated as pustule in several hours after IPL. Both cases show high density of Demodex after IPL. Neither of them had photosensitivity, systemic disease, or any other contraindication for IPL. One of the patients received IPL again a...
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#1Lei Shi (Tongji University)H-Index: 7
#2Min Luo (Tongji University)H-Index: 2
Last.Xiuli Wang (Tongji University)H-Index: 11
view all 15 authors...
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#1Pei LiuH-Index: 2
#2Weitao YangH-Index: 12
Last.Xiuli WangH-Index: 11
view all 10 authors...
Phototherapy, particularly photothermal therapy (PTT) and photodynamic therapy (PDT), has become a promising therapeutic technique for the treatment of skin cancers because of its minial invasiveness, high efficacy, and low side effects. Nevertheless, single modality therapy, either PTT or PDT, has limited clinical effectiveness in treating skin cancers. Thus, combined applications of PTT and PDT have been frequently reported; however, PTT and PDT often require their respective photoagents and e...
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#1Min Luo (Tongji University)H-Index: 2
#2Lei Shi (Tongji University)H-Index: 7
Last.Xiuli Wang (Tongji University)H-Index: 11
view all 13 authors...
AbstractBackground: Laser immunotherapy is a new anti-cancer therapy combining photothermal therapy and immunostimulation. It can eliminate the tumours by damaging tumour cells directly and promoting the release of damage-associated molecular patterns (DAMPs) to enhance tumour immunogenicity. The aim of this study was to investigate the thermal effects of laser immunotherapy and to evaluate the effectiveness and safety of laser immunotherapy for cutaneous squamous cell carcinoma (cSCC).Methods: ...
3 CitationsSource
#1Uma Keyal (Tongji University)H-Index: 5
#2Qiong LuoH-Index: 1
Last.Lei Shi (Tongji University)H-Index: 7
view all 15 authors...
4 CitationsSource
#1Peiru Wang (Tongji University)H-Index: 6
#2Jiatong Han (Tongji University)
Last.Xiuli Wang (Tongji University)H-Index: 11
view all 10 authors...
5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is known to be effective in the treatment of photoaged skin. However, the molecular mechanisms still remain elusive. Protoporphyrin IX (PpIX) fluorescence is primarily located in the epidermis while ALA-PDT affects the dermal collagen, presumably by an indirect mechanism. This study aimed to investigate the molecular communication in low-dose ALA-PDT occurring between epidermal keratinocytes and dermal fibroblasts. Western blotting and enzyme-...
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