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Hans de Boer
EndocrinologySurgeryDiabetes mellitusMedicineGastroenterology
44Publications
16H-index
1,369Citations
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Publications 34
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#1Wendy SchijnsH-Index: 5
#2Abel BoerboomH-Index: 3
Last. Edo O. AartsH-Index: 20
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Summary Background Iron deficiency (ID) is one of the most common postoperative deficiencies that may develop after Roux-en-Y gastric bypass (RYGB). The optimal mode of treatment is uncertain. Aim To compare the efficacy of oral ferrous fumarate (FF), oral ferrous gluconate (FG), and a single intravenous infusion of ferric carboxymaltose (FCM) in women with ID after RYGB. Methods: multicenter randomized controlled trial including 120 women with a serum ferritin Results At three months, persisten...
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Abstract Background After Roux-en-Y Gastric Bypass (RYGB), 15 to 35% of patients fail to lose sufficient weight. Distalization of the limbs of the RYGB (D-RYGB) with shortening of the common channel (CC), has been used to induce additional weight loss. However, this may increase the risk of malnutrition. Objective The aim of this study is to assess post-operative outcomes after D-RYGB with an alimentary limb of 250-300 cm and CC of 100 cm. Setting General hospital, specialized in bariatric surge...
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Objective: To assess the efficacy of long-term calcium and vitamin D treatment on Bone Mineral Density (BMD) in HIV+ patients on combined antiretroviral therapy (cART). Design: Retrospective, singl...
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#1Louise HendrikxH-Index: 1
#2Hans BrandtsH-Index: 4
Last. Hans de BoerH-Index: 16
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A 28-year-old female was admitted 2 years after gastric bypass limb distalization because of severe weight loss, fatigue, chronic diarrhea, massive edema, and a serum albumin of 10 g/L without proteinuria. A diagnosis of severe energy and protein malnutrition was made, and enteral tube feeding was started in combination with pancreatic enzyme supplementation every 3 h. Within 24 h after the start of tube feeding, she developed severe hyperammonemia. Tube feeding was stopped immediately, and this...
2 CitationsSource
#1Carlijn Kuin (WUR: Wageningen University and Research Centre)H-Index: 1
#1Carlijn Kuin (WUR: Wageningen University and Research Centre)H-Index: 1
Last. Hans de BoerH-Index: 16
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Background Severe protein malnutrition, with a serum albumin < 25 g/L, is one of the complications that may develop after bariatric surgery. It is associated with increased morbidity and mortality and requires timely diagnosis and appropriate treatment to prevent rapid clinical deterioration. However, evidence-based recommendations for a specific treatment approach are currently not available. The present study describes the efficacy of a newly developed treatment regimen for post-bariatric pati...
4 CitationsSource
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#2Hannah H R de Boer (UMCG: University Medical Center Groningen)H-Index: 1
Last. Hans de BoerH-Index: 16
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Adequate glucocorticoid replacement in patients with primary or secondary adrenal insufficiency is essential to maintain general well-being. Little is known about the effects of bariatric surgery on glucocorticoid absorption. This study evaluates glucocorticoid absorption before and after bariatric surgery, with assessment of plasma cortisol profiles in five patients receiving glucocorticoid replacement therapy for primary (n = 1) or secondary (n = 4) adrenal insufficiency. One patient underwent...
1 CitationsSource
Context: Obesity-related hyperinsulinism may impede lifestyle-initiated weight loss. Objective: Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men. Design: Twelve-month study comprising an initial 6-month, double-blind trial, followed by a partially de-blinded 6-month extension in men with obesity with a body mass index of 30 to 37.5 kg/m2 and a fasting serum C-p...
2 CitationsSource
Context: It has been suggested that stimulation of lipolysis by diazoxide (DZX)-mediated insulin suppression may be useful in treating obesity. However, the optimal dose to promote lipolysis without causing hyperglycemia is unknown. Objective: To assess the effects of DZX in nondiabetic obese men on lipid and glucose metabolism. Design: Double-blind, placebo (PL)-controlled, 6-month trial in men with a body mass index of 30 to 37.5 kg/m2 treated with a combination of caloric restriction, a stand...
7 CitationsSource
#1Laura N. DedenH-Index: 4
#2Edo O. AartsH-Index: 20
Last. Hans de BoerH-Index: 16
view all 7 authors...
Background Pharmacokinetic data suggest that the risk of metformin-associated lactic acidosis (MALA) may be increased after Roux-en-Y gastric bypass (RYGB) surgery. The aim of this study was to examine the impact of metformin on plasma lactate levels before and after RYGB surgery.
2 CitationsSource
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