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Rahul Patil
Uka Tarsadia University
9Publications
3H-index
44Citations
Publications 11
Newest
Abstract This study investigates the stabilization of graphene oxide (GO) nanosheets in polyethylene oxide-polypropylene oxide (PEO-PPO) block copolymers (P103, P123 and F127). Changes in micellization of copolymers upon GO addition were monitored using dynamic light (DLS) and small angle neutron scattering (SANS). Structural developments at sheet surface were studied with two possibilities; (i) adsorption of PPO block over hydrophobic basal plane allowing the engagement of hydrophilic PEO with ...
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Abstract This study reports a detailed characterization of a nonionic microemulsion (µE) composed of n-butylacetate/α-tocopheryl polyethylene glycol succinate (TPGS)/alcohol/water. Two approaches of expanding the monophasic area were explored; (i) addition of Pluronic® 123 (P123) in aqueous phase, and (ii) use of short chain alcohol (CnHn+1OH; n = 2–4) as cosurfactant. Pseudo-ternary phase diagrams were constructed using water titration method. Characterizations were performed using dynamic ligh...
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#1Rahul Patil (Uka Tarsadia University)H-Index: 3
#2Vrushti Kansara (Uka Tarsadia University)H-Index: 1
Last.Sanjay Tiwari (Uka Tarsadia University)H-Index: 10
view all 7 authors...
Abstract Graphene possesses a large surface area and offers high loading capacity for aromatic compounds. However, the load is quickly released in the absence of rate limiting diffusion barrier. In this study, we have explored the electrostatic interaction between polyanionic hyaluronic acid (HA) and cationized reduced graphene oxide (rGO) as a means to develop a reinforced hydrogel matrix. We tested if; (i) degradation kinetics of HA matrix can be modulated in the presence of cationized nanoshe...
1 CitationsSource
#1Rahul Patil (Uka Tarsadia University)H-Index: 3
#2Pratap Bahadur (Veer Narmad South Gujarat University)H-Index: 26
Last.Sanjay Tiwari (Uka Tarsadia University)H-Index: 10
view all 3 authors...
Abstract Graphene is one-atom thick nanocarbon displaying a unique honeycomb structure and extensive conjugation. In addition to high surface area to mass ratio, it displays unique optical, thermal, electronic and mechanical properties. Atomic scale tunability of graphene has attracted immense research interest with a prospective utility in electronics, desalination, energy sectors, and beyond. Its intrinsic opto-thermal properties are appealing from the standpoint of multimodal drug delivery, i...
1 CitationsSource
#1Habiba Pathan (Uka Tarsadia University)H-Index: 1
#2Rahul Patil (Uka Tarsadia University)H-Index: 3
Last.Sanjay Tiwari (Uka Tarsadia University)H-Index: 10
view all 6 authors...
Abstract We report the effect of concentration of 1-butyl-3-methylimidazolium ([C 4 mim] + ) based ionic liquids (ILs) with different anions (Cl, BF 4 , CF 3 SO 3 , PF 6 , NTf 2 and OS) on micelles of d-α-tocopheryl polyethylene glycol succinate (TPGS). A distinct series of ILs possessing identical anion (Cl − ) but cation [C n mim + ) with increasing alkyl chain length (butyl, hexyl, octyl and decyl) was also tested. TPGS-IL mixed micelles were characterized through small angle neutron scatteri...
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#1Sanjay Tiwari (Uka Tarsadia University)H-Index: 10
#2Rahul Patil (Uka Tarsadia University)H-Index: 3
Last.Pratap Bahadur (Veer Narmad South Gujarat University)H-Index: 26
view all 4 authors...
Abstract Pullulan (PUL), a linear exo-polysaccharide, is useful in industries as diverse as food, cosmetics and pharmaceuticals. PUL presents many favorable characteristics, such as renewable origin, biocompatibility, stability, hydrophilic nature, and availability of reactive sites for chemical modification. With an inherent affinity to asialoglycoprotein receptors, PUL can be used for targeted drug delivery to the liver. Besides, these primary properties have been combined with modern syntheti...
1 CitationsSource
#1Shubham Jain (Uka Tarsadia University)H-Index: 1
#2Sonia Pandey (Uka Tarsadia University)H-Index: 5
Last.Sanjay Tiwari (Uka Tarsadia University)H-Index: 10
view all 9 authors...
d-α-Tocopheryl polyethylene glycol succinate (TPGS), a polyethylene glycol condensate, is a biologically important nonionic amphiphile. In this study, we report on aqueous solution behavior of TPGS with a focus on its clouding, surface activity, micellar characteristics, and solubilization capacity for a model hydrophobic drug, carbamazepine (CBZ). Micelles were characterized by dynamic light and small-angle neutron scattering studies as a function of temperature, salt addition, and CBZ solubili...
1 CitationsSource
#1Furqan A. Maulvi (Uka Tarsadia University)H-Index: 9
#2Rahul Patil (Uka Tarsadia University)H-Index: 3
Last.Dinesh O. ShahH-Index: 53
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Abstract Contact lenses are ideally suited for extended drug delivery to the ocular tissues, but incorporation of any particulate system affects the critical properties of the contact lens. Timolol loading by the conventional soaking method does not significantly alter the critical properties of the contact lens. However, there are challenges of low drug loading and high burst release. This research work aimed to investigate the effect of gold nanoparticles (GNPs) on loading and its release kine...
2 CitationsSource
#1Vrushti Kansara (Uka Tarsadia University)H-Index: 1
#2Rahul Patil (Uka Tarsadia University)H-Index: 3
Last.Sanjay Tiwari (Uka Tarsadia University)H-Index: 10
view all 6 authors...
Abstract This study reports our attempt of improving dispersibility of reduced graphene oxide (rGO) through differential functionalization of carboxyl moieties with ethylene diamine (EDA) and folic acid (FA) using carbodimide chemistry. Successful covalent linkage was demonstrated through FT-IR, Raman and energy dispersive X-ray spectroscopy. Functionalized nanosheets (GNs) produced a stable dispersion up to 0.1 wt% which remained unaffected against salt- and protein-induced aggregation. Hemolys...
5 CitationsSource
#1Sanjay TiwariH-Index: 10
#2Rahul PatilH-Index: 3
Last.Pratap BahadurH-Index: 26
view all 3 authors...
Soft tissue reconstructs require materials that form three-dimensional (3-D) structures supportive to cell proliferation and regenerative processes. Polysaccharides, due to their hydrophilicity, biocompatibility, biodegradability, abundance, and presence of derivatizable functional groups, are distinctive scaffold materials. Superior mechanical properties, physiological signaling, and tunable tissue response have been achieved through chemical modification of polysaccharides. Moreover, an approp...
17 CitationsSource
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