Jing Yang
China Medical University (PRC)
Publications 4
#2Jing Yang (PRC: China Medical University (PRC))H-Index: 3
Last.Jian DuH-Index: 3
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Abstract The incidence and mortality of type 2 diabetes mellitus (T2DM) rank among the top ten worldwide. Emerging studies indicate pathological roles for the immune system in inflammation, insulin resistance and islet β-cell damage in subjects with T2DM. Methionine enkephalin (MENK) is present in endocrine cells of the pancreas and has been suggested to be an important mediator between the immune and neuroendocrine systems. Therefore, it may play a role in modulating insulin secretion from isle...
#1Na Ao (PRC: China Medical University (PRC))H-Index: 3
#2Jing Yang (PRC: China Medical University (PRC))H-Index: 3
Last.Jian Du (PRC: China Medical University (PRC))H-Index: 3
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Aim Glucagon-like peptide-1 (GLP-1) has been increasingly recognized for treating diabetes mellitus, and for its potential to effectively treat non-alcoholic fatty liver disease (NAFLD). However, the mechanisms of GLP-1 induction in NAFLD are not completely known. We investigated whether GLP-1 can protect against NAFLD by alleviating endoplasmic reticulum (ER) stress. Methods Male Sprague–Dawley rats were fed a high-fat diet and treated with a long-acting GLP-1 receptor agonist, liraglutide. Bio...
#1Jing Yang (PRC: China Medical University (PRC))H-Index: 3
#2Na Ao (PRC: China Medical University (PRC))H-Index: 3
Last.Yini He (PRC: China Medical University (PRC))H-Index: 1
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The purpose of this study was to investigate whether the glucagon-like peptide-1 (GLP-1) analog liraglutide can alleviate endoplasmic reticulum (ER) stress and insulin resistance (IR) in the liver of high-fat diet-induced insulin-resistant rats. Eighty-five male Sprague–Dawley rats were fed with normal chow or a high-fat diet for 12 weeks. The IR was evaluated using the hyperinsulinemic-euglycemic clamp technique. The rats in the HF group were further divided into four groups and were treated wi...
#1Lina Pei (PRC: China Medical University (PRC))H-Index: 1
#2Jing Yang (PRC: China Medical University (PRC))H-Index: 3
Last.Yingyan Zhang (PRC: China Medical University (PRC))H-Index: 1
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Abstract Aims To investigate whether metformin regulates chemerin expression in vivo by alleviating ER stress. Methods Male Sprague-Dawley rats were fed a high-fat or normal diet for 10 weeks to induce insulin resistance. During the following 6 weeks, the rats were divided into four groups: normal diet without treatment (NC), normal diet with metformin treatment (NM), high-fat diet without metformin (HF), and high-fat diet with metformin (HM). Body weight, fasting glucose, basal insulin level, i...