Petter Bjornstad
University of Colorado Denver
Publications 110
#1Daniel H. van Raalte (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Petter Bjornstad (University of Colorado Denver)H-Index: 15
Last.David Z.I. Cherney (U of T: University of Toronto)H-Index: 28
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OBJECTIVE In people with type 2 diabetes, sodium–glucose cotransporter 2 inhibitors (SGLT2i) reduce cardiovascular risk and progression of diabetic kidney disease. Our aim was to determine whether sotagliflozin (SOTA), a dual SGLT1i and SGLT2i, had favorable effects on clinical biomarkers suggestive of kidney protection in adults with type 1 diabetes. RESEARCH DESIGN AND METHODS In this 52-week pooled analysis, 1,575 adults enrolled in the inTandem1 and inTandem2 trials were randomized to SOTA 2...
#1Vikas Srinivasan Sridhar (U of T: University of Toronto)
#2Jaya Prakash Nath Ambinathan (U of T: University of Toronto)
Last.Heather N. Reich (UHN: University Health Network)H-Index: 19
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#1Ebaa Al-Ozairi (Kuniv: Kuwait University)H-Index: 4
#2Christopher J. Rivard (University of Colorado Denver)H-Index: 33
Last.Richard J. Johnson (University of Colorado Denver)H-Index: 115
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#1Sherry G. Mansour (Yale University)H-Index: 4
Last.Chirag R. Parikh (Johns Hopkins University)H-Index: 63
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Background and objectives Marathon runners develop transient AKI with urine sediments and injury biomarkers suggesting nephron damage. Design, setting, participants, & measurements To investigate the etiology, we examined volume and thermoregulatory responses as possible mechanisms in runners’ AKI using a prospective cohort of runners in the 2017 Hartford Marathon. Vitals, blood, and urine samples were collected in 23 runners 1 day premarathon and immediately and 1 day postmarathon. We measured ...
#1Pattara Wiromrat (University of Colorado Denver)H-Index: 1
#2Petter Bjornstad (University of Colorado Denver)H-Index: 15
Last.R. Paul Wadwa (University of Colorado Denver)H-Index: 27
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Abstract Early diabetic kidney disease (DKD) occurs in adolescents with type 1 diabetes (T1D). Lower serum uromodulin (SUMOD) predicts DKD progression in adults with T1D. In this study, we demonstrate that lower SUMOD is associated with urinary albumin excretion in adolescents with T1D, suggesting a potential relationship between SUMOD and early kidney dysfunction in T1D youth.
Abstract Cyclic guanosine monophosphate (cGMP) influences intrarenal hemodynamics in animal models, but the relationship between cGMP and renal function in adults with type 1 diabetes (T1D) remains unclear. In this study, plasma cGMP correlated with efferent arteriolar resistance, effective renal plasma flow, and renal vascular resistance in adults with T1D.
#1Pattara Wiromrat (University of Colorado Denver)H-Index: 1
#2Petter Bjornstad (University of Colorado Denver)H-Index: 15
Last.Laura Pyle (University of Colorado Denver)H-Index: 18
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Abstract Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Lower SUMOD correlated with aortic stiffness, suggesting its potential as a CVD biomarker in T1D.
#1Yuliya LytvynH-Index: 10
#2Petter BjornstadH-Index: 15
Last.David Z.I. CherneyH-Index: 28
view all 9 authors...
Elevated copeptin, a stable surrogate of vasopressin, is recognized to be higher in T1D and predicts diabetic kidney disease and cardiovascular (CV) mortality. Vasopressin increases renal oxygen consumption through enhanced sodium reabsorption and may result in renal hypoxia. Given the natriuretic and cardiorenal protective effects of SGLT2 inhibition (SGLT2i) in clinical trials, our aim was to: 1) examine serum copeptin in adults with T1D after SGLT2i with empagliflozin (EMPA) for 8-weeks; and ...