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Jin-Ping Li
Capital Medical University
Molecular biologyHeparanaseHeparan sulfateBiochemistryBiology
135Publications
38H-index
5,270Citations
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Publications 136
Newest
#1Gan-Lin Zhang (Capital Medical University)H-Index: 9
#2Lilach Gutter-Kapon (Rappaport Faculty of Medicine)H-Index: 4
Last. Ralph D. Sanderson (UAB: University of Alabama at Birmingham)H-Index: 58
view all 13 authors...
Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, angiogenesis and metastasis. Much of the impact of heparanase on tumor progression is related to its function in mediating tumor-host crosstalk, priming the tumor microenvironment to better support tumor growth and metastasis. We have utilized mice over-expressing (Hpa-tg) heparanase to reveal the role of host heparanase in tumor initiation, growth and metastasis. W...
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#1Ulf Lindahl (Uppsala University)H-Index: 74
Last. Jin-Ping Li (Uppsala University)H-Index: 38
view all 2 authors...
A prominent clinical feature of severe Covid-19 infection is respiratory failure associated with pulmonary coagulopathy. Recent reports published in Thrombosis and Haemostasis show that treatment with low-molecular weight heparin (LMWH) decreases mortality in critically ill patients with sepsis-induced hypercoagulation, and thus argue for prophylactic administration of the anticoagulant. In addition, the authors point to non-anticoagulant activities of heparin, in particular anti-inflammatory ef...
5 CitationsSource
#1Lu Ming Wan (Academy of Military Medical Sciences)
#2Shi Kun Zhang (Academy of Military Medical Sciences)
Last. Hui ZhongH-Index: 15
view all 17 authors...
Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulfate and hence participates in remodeling of the extracellular matrix, leading to release of cytokines that are immobilized by binding to heparan sulfate proteoglycans (HSPGs), and consequently activating signaling pathways. This function of HPSE is correlated to its expression level that is normally very low in majority of the tissues. Exceptionally, human platelets express high level of HPSE, suggesting a unique physiolo...
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#1Tianji Zhang (Huada: Beijing University of Chemical Technology)H-Index: 3
#2Shaoshuai Xie (SDU: Shandong University)H-Index: 1
Last. Tianwei Tan (Huada: Beijing University of Chemical Technology)H-Index: 51
view all 10 authors...
Abstract Building blocks characterization is a significant approach for understanding the molecular structure of heparin and its derivatives. Nitrous acid (HONO) depolymerization of heparin generates oligosaccharides that maintain the epimerization conformation on C5 of the uronic acids, reflecting the authentic structure of the parental chain. HONO treatment at pH 1.5 selectively cleaves the bond between N-sulfated glucosamine and hexuronic acid, resulting mainly disaccharides, as well as tetra...
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#1Tianji Zhang (Huada: Beijing University of Chemical Technology)H-Index: 3
#2Rui Zhang (Huada: Beijing University of Chemical Technology)H-Index: 3
Last. Jin-Ping Li (Huada: Beijing University of Chemical Technology)H-Index: 38
view all 7 authors...
Abstract Glycosaminoglycans (GAGs) are unbranched polyanionic polysaccharides involved in a wide spectrum of biological activities. Accumulation and/or structural alteration of GAGs in biological samples have been found correlated with diseases, making these molecules potential biomarkers for the diagnosis of these diseases and monitoring treatment effects. Detection and structural characterization of GAGs in biological samples have been challenging mainly due to their low abundance, structural ...
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#1Jin-Ping Li (Uppsala University)H-Index: 38
Last. Xiao Zhang (Uppsala University)
view all 2 authors...
Amyloidosis refers to a group of diseases characterized by abnormal deposition of denatured endogenous proteins, termed amyloid, in the affected organs. Analysis of biopsy and autopsy tissues from patients revealed the presence of heparan sulfate proteoglycans (HSPGs) along with amyloid proteins in the deposits. For a long time, HSPGs were believed to occur in the deposits as an innocent bystander. Yet, the consistent presence of HSPGs in various deposits, regardless of the amyloid species, led ...
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#1Ulf Lindahl (Uppsala University)H-Index: 74
Last. Jin-Ping Li (Uppsala University)H-Index: 38
view all 2 authors...
: Heparanase was discovered during a study of the heparin proteoglycan (serglycin) in mast cells. Newly synthesized polysaccharide chains, kDa 60-100 x 103, were rapidly degraded to fragments similar in size to commercially available heparin (averaging 15 x 103). Analysis of the degradation products identified reducing-terminal glucuronic acid residues, shown by studies of heparin biosynthesis to be of sD-configuration in the intact polymer. Heparanase, thus identified as an endo-sD-glucuronidas...
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#1Bushan Xie (Uppsala University)H-Index: 1
#2Xingxing He (NCU: Nanchang University)H-Index: 1
Last. Yingbo Lin (KI: Karolinska Institutet)H-Index: 7
view all 7 authors...
Abstract The use of highly efficient high-throughput screening (HTS) platform has recently gained more attention as a plausible approach to identify de novo therapeutic application potential of conventional anti-tumor drugs for cancer treatments. In this study, we used hepatocellular carcinoma (HCC) cells as models to identify cytotoxic compounds by HTS. To identify cytotoxic compounds for potential HCC treatments, 3271 compounds from three well established small molecule libraries were screened...
2 CitationsSource
#1Eriko Nakato (UMN: University of Minnesota)H-Index: 2
#2Xin Liu (Uppsala University)H-Index: 1
Last. Hiroshi Nakato (UMN: University of Minnesota)H-Index: 24
view all 9 authors...
: A class of carbohydrate-modified proteins, heparan sulfate proteoglycans (HSPGs), play critical roles both in normal development and during disease. Genetic studies using a model organism, Drosophila, have been contributing to understanding the in vivo functions of HSPGs. Despite the many strengths of the Drosophila model for in vivo studies, biochemical analysis of Drosophila HS is somewhat limited, mainly due to the insufficient amount of the material obtained from the animal. To overcome th...
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#1Rui Zhang (Huada: Beijing University of Chemical Technology)H-Index: 1
#2Tianji ZhangH-Index: 3
Last. Tianwei Tan (Huada: Beijing University of Chemical Technology)H-Index: 51
view all 7 authors...
Abstract Heparin is a highly sulfated polysaccharide, applied in clinic for treatment of thrombotic diseases. The biological activity is closely related to its molecular structure e.g. compositions of disaccharides and oligosaccharides units. The classical method to isolate the oligosaccharides after depolymerization by heparinases or nitrous acid I s by size exclusion chromatography which is a time-consuming process. In this study, we explored the possibility for rapid separation of oligosaccha...
1 CitationsSource
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