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Lindsey A. Vandergrift
Harvard University
9Publications
3H-index
23Citations
Publications 9
Newest
#1Yannick Berker (DKFZ: German Cancer Research Center)
#2Lindsey A. Vandergrift (Harvard University)H-Index: 3
Last.Leo K. Cheng (Harvard University)H-Index: 36
view all 13 authors...
Low-dose CT has shown promise in detecting early stage lung cancer. However, concerns about the adverse health effects of radiation and high cost prevent its use as a population-wide screening tool. Effective and feasible screening methods to triage suspicious patients to CT are needed. We investigated human lung cancer metabolomics from 93 paired tissue-serum samples with magnetic resonance spectroscopy and identified tissue and serum metabolomic markers that can differentiate cancer types and ...
#1Sarah S. Dinges (Charité)
#2Annika Hohm (Harvard University)H-Index: 2
Last.Leo K. Cheng (Harvard University)H-Index: 36
view all 7 authors...
Urinary tests have been used as noninvasive, cost-effective tools for screening, diagnosis and monitoring of diseases since ancient times. As we progress through the 21st century, modern analytical platforms have enabled effective measurement of metabolites, with promising results for both a deeper understanding of cancer pathophysiology and, ultimately, clinical translation. The first study to measure metabolomic urinary cancer biomarkers using NMR and mass spectrometry (MS) was published in 20...
#1Lindsey A. Vandergrift (Harvard University)H-Index: 3
#2Emily A. Decelle (Harvard University)H-Index: 5
Last.Leo K. Cheng (Harvard University)H-Index: 36
view all 12 authors...
Prostate cancer alters cellular metabolism through events potentially preceding cancer morphological formation. Magnetic resonance spectroscopy (MRS)-based metabolomics of histologically-benign tissues from cancerous prostates can predict disease aggressiveness, offering clinically-translatable prognostic information. This retrospective study of 185 patients (2002–2009) included prostate tissues from prostatectomies (n = 365), benign prostatic hyperplasia (BPH) (n = 15), and biopsy cores from ca...
#1Annika Kurreck (FU: Free University of Berlin)H-Index: 1
#2Lindsey A. Vandergrift (Harvard University)H-Index: 3
Last.Leo K. Cheng (Harvard University)H-Index: 36
view all 6 authors...
Prostate cancer (PCa), the most common cancer and second leading cause of cancer death in American men, presents the clinical challenge of distinguishing between indolent and aggressive tumors for proper treatment. PCa presents significant alterations in metabolic pathways that can potentially be measured using techniques like mass spectrometry (MS) or MS imaging (MSI) and used to characterize PCa aggressiveness. MS quantifies metabolomic, proteomic, and lipidomic profiles of biological systems ...
#1Johannes NowakH-Index: 3
#2Stephanie Jünger (University of Bonn)H-Index: 2
Last.Monika Warmuth-MetzH-Index: 42
view all 10 authors...
Purpose Epigenetic profiling has recently identified clinically and molecularly distinct subgroups of ependymoma. The 2016 World Health Organization (WHO) classification recognized supratentorial ependymomas (ST-EPN) with REL-associated protein/p65 (RELA) fusion as a clinicopathological entity. These tumors represent 70% of pediatric ST-EPN characterized by recurrent C11orf95-RELA fusion transcripts, which lead to pathological activation of the nuclear factor ‘kappa-light-chain-enhancer’ of acti...
#1Christopher Dietz (University of Würzburg)H-Index: 1
#2Felix Ehret (University of Würzburg)H-Index: 1
Last.Leo K. Cheng (Harvard University)H-Index: 36
view all 10 authors...
High-resolution magic angle spinning (HRMAS) MRS is a powerful method for gaining insight into the physiological and pathological processes of cellular metabolism. Given its ability to obtain high-resolution spectra of non-liquid biological samples, while preserving tissue architecture for subsequent histopathological analysis, the technique has become invaluable for biochemical and biomedical studies. Using HRMAS MRS, alterations in measured metabolites, metabolic ratios, and metabolomic profil...
#1Eva Kaebisch (Charité)H-Index: 1
#2Taylor L. Fuss (Harvard University)H-Index: 3
Last.Leo K. Cheng (Harvard University)H-Index: 36
view all 6 authors...
High-resolution magic angle spinning (HRMAS) MRS allows for direct measurements of non-liquid tissue and cell specimens to present valuable insights into the cellular metabolisms of physiological and pathological processes. HRMAS produces high-resolution spectra comparable to those obtained from solutions of specimen extracts but without complex metabolite extraction processes, and preserves the tissue cellular structure in a form suitable for pathological examinations following spectroscopic an...
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