Andrew A. Maudsley
University of Miami
Analytical chemistryChemistryNuclear magnetic resonanceMedicineMagnetic resonance spectroscopic imaging
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Publications 203
#1Kai G. Kahl (MHH: Hannover Medical School)H-Index: 28
#2Sirin Atalay (MHH: Hannover Medical School)
Last. Xiao-Qi Ding (MHH: Hannover Medical School)H-Index: 15
view all 9 authors...
Abstract Introduction Major depressive disorder (MDD) is a severe mental disorder with a neurobiological basis that is poorly understood. Several studies demonstrated widespread, functional and neurometabolic alterations in MDD. However, little is known about whole brain neurometabolic alterations in MDD. Method Thirty-two patients with MDD and 32 paired on a one-to-one basis healthy controls (CTRL) underwent 1H-whole brain spectroscopic (1H-WBS) imaging. Lobar and cerebellar metabolite concentr...
#1Mohammed Goryawala (UM: University of Miami)H-Index: 13
#2Molly Sullivan (UM: University of Miami)H-Index: 1
Last. Andrew A. Maudsley (UM: University of Miami)H-Index: 53
view all 3 authors...
PURPOSE: Visual review of individual spectra in magnetic resonance spectroscopic imaging (MRSI) data benefits from the application of spectral smoothing; however, if this processing step is applied prior to spectral analysis this can impact the accuracy of the quantitation. This study aims to analyze the effect of spectral denoising and apodization smoothing on the quantitation of whole-brain MRSI data obtained at short TE. METHODS: Short-TE MRSI data obtained at 3T were analyzed with no spectra...
1 CitationsSource
#1Rhoshel Lenroot (UNM: University of New Mexico)H-Index: 41
#2Joel Upston (UNM: University of New Mexico)H-Index: 2
Last. Juan R. Bustillo (UNM: University of New Mexico)H-Index: 46
view all 8 authors...
#1Juan R. Bustillo (UNM: University of New Mexico)H-Index: 46
#2Joel Upston (UNM: University of New Mexico)H-Index: 2
Last. Rhoshel Lenroot (UNM: University of New Mexico)H-Index: 41
view all 8 authors...
Proton magnetic resonance spectroscopy (1H-MRS) studies have examined glutamatergic abnormalities in schizophrenia, mostly in single voxels. Though the critical brain nodes remain unknown, schizophrenia involves networks with broad abnormalities. Hence, glutamine plus glutamate (Glx) and other metabolites were examined with whole-brain 1H-MRS, in early schizophrenia. Three dimensional 1H-MRS was acquired in young schizophrenia subjects (N = 36, 19 antipsychotic-naive and 17 antipsychotic-treated...
#1Andrew A. Maudsley (UM: University of Miami)H-Index: 53
#2Ovidiu C. Andronesi (Harvard University)H-Index: 26
Last. Brian J. Soher (Duke University)H-Index: 34
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Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to date, these methods have not had a significant impact on clinical care, and their use remains largely confined to the research community and a limited number of clinical sites. The MRSI methods currently implemented on clinical MRI instruments have remained essentially unchanged for two decades, with only incremental improvements in seque...
1 CitationsSource
#1Christina Mueller (UAB: University of Alabama at Birmingham)H-Index: 2
#2Joanne C. Lin (UAB: University of Alabama at Birmingham)H-Index: 3
Last. Jarred Younger (UAB: University of Alabama at Birmingham)H-Index: 25
view all 5 authors...
Previous neuroimaging studies have detected markers of neuroinflammation in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Magnetic Resonance Spectroscopy (MRS) is suitable for measuring brain metabolites linked to inflammation, but has only been applied to discrete regions of interest in ME/CFS. We extended the MRS analysis of ME/CFS by capturing multi-voxel information across the entire brain. Additionally, we tested whether MRS-derived brain temperature is elevated...
9 CitationsSource
#1Mohammed Goryawala (UM: University of Miami)H-Index: 13
#2Efrat Saraf-Lavi (UM: University of Miami)H-Index: 9
Last. Andrew A. Maudsley (UM: University of Miami)H-Index: 53
view all 6 authors...
BACKGROUND AND PURPOSE: Mutations in isocitrate dehydrogenase (IDH) have a direct effect on gliomagenesis. The purpose of this study is to quantify differences in brain metabolites due to IDH mutations. METHODS: Magnetic Resonance Spectroscopic Imaging (MRSI) was performed in 35 patients with gliomas of different grade and varied IDH mutation status. Volumes of interest (VOIs) for active tumor (tVOI), peritumoral area (pVOI), and contralateral normal-appearing white matter (cVOI) were created. M...
#1Joshua Chiappelli (UMB: University of Maryland, Baltimore)H-Index: 18
#2Laura M. Rowland (UMB: University of Maryland, Baltimore)H-Index: 27
Last. L. Elliot Hong (UMB: University of Maryland, Baltimore)H-Index: 34
view all 15 authors...
Cardiovascular risk factors such as dyslipidemia and hypertension increase the risk for white matter pathology and cognitive decline. We hypothesize that white matter levels of N-acetylaspartate (NAA), a chemical involved in the metabolic pathway for myelin lipid synthesis, could serve as a biomarker that tracks the influence of cardiovascular risk factors on white matter prior to emergence of clinical changes. To test this, we measured levels of NAA across white matter and gray matter in the br...
#1Eric A. Mellon (UM: University of Miami)H-Index: 4
#1Eric A. Mellon (UM: University of Miami)H-Index: 18
Last. Hui-Kuo Shu (Emory University)H-Index: 20
view all 10 authors...
#1Martin Wilson (University of Birmingham)H-Index: 20
#2Ovidiu C. Andronesi (Harvard University)H-Index: 26
Last. Franklyn A. Howe (St George's, University of London)H-Index: 54
view all 49 authors...
Proton MRS (1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine use is largely restricted to specialized centers with good access to MR research support. Widespread adoption has been slow for several reasons, and technical challenges toward obtaining reliable good-quality results have been identified as a contributing facto...
7 CitationsSource