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Fred A. M. G. van Geenen
Wageningen University and Research Centre
Analytical chemistryAmbient ionizationMass spectrometryChemistryLaser ablation electrospray ionization
3Publications
2H-index
9Citations
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Publications 3
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#1Fred A. M. G. van Geenen (WUR: Wageningen University and Research Centre)H-Index: 2
#2Maurice C. R. Franssen (WUR: Wageningen University and Research Centre)H-Index: 19
Last. Michel W. F. Nielen (WUR: Wageningen University and Research Centre)H-Index: 45
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In drug discovery, it is important to identify phase I metabolic modifications as early as possible to screen for inactivation of drugs and/or activation of prodrugs. As the major class of reactions in phase I metabolism is oxidation reactions, oxidation of drugs with TiO2 photocatalysis can be used as a simple non-biological method to initially eliminate (pro)drug candidates with an undesired phase I oxidation metabolism. Analysis of reaction products is commonly achieved with mass spectrometry...
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#1Fred A. M. G. van Geenen (WUR: Wageningen University and Research Centre)H-Index: 2
#2Maurice C. R. Franssen (WUR: Wageningen University and Research Centre)H-Index: 19
Last. Michel W. F. Nielen (WUR: Wageningen University and Research Centre)H-Index: 45
view all 4 authors...
Reactions in confined compartments like charged microdroplets are of increasing interest, notably because of their substantially increased reaction rates. When combined with ambient ionization mass spectrometry (MS), reactions in charged microdroplets can be used to improve the detection of analytes or to study the molecular details of the reactions in real time. Here, we introduce a reactive laser ablation electrospray ionization (reactive LAESI) time-resolved mass spectrometry (TRMS) method to...
2 CitationsSource
Direct analysis of synthetic fibers under ambient conditions is highly desired to identify the polymer, the finishes applied and irregularities that may compromise its performance and value. In this paper, laser ablation electrospray ionization ion mobility time-of-flight mass spectrometry (LAESI-IMS-TOF-MS) was used for the analysis of synthetic polymers and fibers. The key to this analysis was the absorption of laser light by aliphatic and aromatic nitrogen functionalities in the polymers. Ana...
7 CitationsSource
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