Yi Lin
Fred Hutchinson Cancer Research Center
Genome-wide association studyCancerSingle-nucleotide polymorphismColorectal cancerMedicine
What is this?
Publications 52
#1Julia D Labadie (UW: University of Washington)
#2Tabitha A. Harrison (Fred Hutchinson Cancer Research Center)H-Index: 22
Last. Andrew T. Chan (Harvard University)H-Index: 80
view all 34 authors...
#1Jeroen R. Huyghe (Fred Hutchinson Cancer Research Center)H-Index: 18
#2Tabitha A. Harrison (Fred Hutchinson Cancer Research Center)H-Index: 22
Last. Yi Lin (Fred Hutchinson Cancer Research Center)H-Index: 14
view all 141 authors...
Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the cont...
#1Peter T. Campbell (ACS: American Cancer Society)H-Index: 38
#2Yi Lin (Fred Hutchinson Cancer Research Center)H-Index: 14
Last. Jenny Chang-Claude (DKFZ: German Cancer Research Center)H-Index: 89
view all 39 authors...
BACKGROUND: Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk. METHODS: We tested multiplicative statistical interactions between BMI (per 5 kg.m2) and approximately 2.7 million single nucleotide polymorphisms (SNPs) with colorectal cancer risk among 14,059 colorectal cancer case (53.2% women) and 14,416 control (53.8% women) participants. All analyses were stratified by sex a priori. Statistical methods included two-step (i....
#1Alexi N. Archambault (NYU: New York University)H-Index: 1
#2Yu-Ru Su (Fred Hutchinson Cancer Research Center)H-Index: 2
Last. Richard B. Hayes (NYU: New York University)H-Index: 102
view all 134 authors...
Abstract Background & Aims Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC. Methods We studied risk for CRC associated with a weighted PRS in 12,197 participants young...
3 CitationsSource
#1Zhiyu Xia (UW: University of Washington)
#2Yu Ru Su (Fred Hutchinson Cancer Research Center)H-Index: 3
Last. Demetrius Albanes (NIH: National Institutes of Health)H-Index: 102
view all 49 authors...
BACKGROUND: Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbations in metabolic traits (e.g. insulin resistance and glucose homeostasis). Identification of interactions between variation in genes and these metabolic risk factors may identify novel biologic insights into CRC etiology. METHODS: To improve statistical power and interpretation for gene-environment interaction (G x E) testing, we tested genetic variants that regulate ...
#1Dong Hang (Nanjing Medical University)H-Index: 3
#2Amit D. Joshi (Harvard University)H-Index: 27
Last. Mingyang Song (Harvard University)H-Index: 30
view all 17 authors...
BACKGROUND: Increasing evidence suggests that conventional adenomas (CAs) and serrated polyps (SPs) represent two distinct groups of precursor lesions for colorectal cancer (CRC). The influence of common genetic variants on risk of CAs and SPs remain largely unknown. METHODS: Among 27 426 participants within three prospective cohort studies, we created a weighted genetic risk score (GRS) based on 40 CRC-related single nucleotide polymorphisms (SNPs) identified in previous genome-wide association...
3 CitationsSource
#1Dong HangH-Index: 12
#2Amit D. JoshiH-Index: 27
Last. Ulrike PetersH-Index: 66
view all 17 authors...
#1Barbara Pardini (UNITO: University of Turin)H-Index: 19
#2Alda Corrado (UniPi: University of Pisa)H-Index: 11
Last. Stefano Landi (UniPi: University of Pisa)H-Index: 40
view all 41 authors...
: Interindividual differences in DNA repair systems may play a role in modulating the individual risk of developing colorectal cancer. To better ascertain the role of DNA repair gene polymorphisms on colon and rectal cancer risk individually, we evaluated 15,419 single nucleotide polymorphisms (SNPs) within 185 DNA repair genes using GWAS data from the Colon Cancer Family Registry (CCFR) and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), which included 8,178 colon cancer,...
#1Sarah A. Pendergrass (Genentech)H-Index: 29
#1Sarah A. Pendergrass (Genentech)H-Index: 1
Last. Dana C. CrawfordH-Index: 2
view all 29 authors...
We performed a hypothesis-generating phenome-wide association study (PheWAS) to identify and characterize cross-phenotype associations, where one SNP is associated with two or more phenotypes, between thousands of genetic variants assayed on the Metabochip and hundreds of phenotypes in 5,897 African Americans as part of the Population Architecture using Genomics and Epidemiology (PAGE) I study. The PAGE I study was a National Human Genome Research Institute-funded collaboration of four study sit...
#1Xiaoliang Wang (UW: University of Washington)H-Index: 3
#2Kelli O'Connell (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 5
Last. Mengmeng Du (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 14
view all 27 authors...
Objective ‘Environmental’ factors associated with colorectal cancer (CRC) risk include modifiable and non-modifiable variables. Whether those with different non-modifiable baseline risks will benefit similarly from reducing their modifiable CRC risks remains unclear. Design Using 7945 cases and 8893 controls from 11 population-based studies, we combined 17 risk factors to characterise the overall environmental predisposition to CRC (environmental risk score (E-score)). We estimated the absolute ...