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Alfredo Perales-Puchalt
Wistar Institute
49Publications
15H-index
895Citations
Publications 50
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#1John D. Lueck (UR: University of Rochester)H-Index: 10
#2Jae Seok Yoon (Cystic Fibrosis Foundation)H-Index: 1
Last.Christopher A. Ahern (Roy J. and Lucille A. Carver College of Medicine)H-Index: 22
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Premature termination codons (PTCs) are responsible for 10–15% of all inherited disease. PTC suppression during translation offers a promising approach to treat a variety of genetic disorders, yet small molecules that promote PTC read-through have yielded mixed performance in clinical trials. Here we present a high-throughput, cell-based assay to identify anticodon engineered transfer RNAs (ACE-tRNA) which can effectively suppress in-frame PTCs and faithfully encode their cognate amino acid. In ...
4 CitationsSource
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Last.Megan C. WiseH-Index: 11
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#1Krzysztof WojtakH-Index: 1
Last.David B. WeinerH-Index: 81
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Infectious diseases are linked to 15%–20% of cancers worldwide. Among them, Epstein–Barr virus (EBV) is an oncogenic herpesvirus that chronically infects over 90% of the adult population, with over 200,000 cases of cancer and 150,000 cancer-related deaths attributed to it yearly. Acute EBV infection can present as infectious mononucleosis, and lead to the future onset of multiple cancers, including Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, and gastric carcinoma. Many of these...
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Last.David B. WeinerH-Index: 81
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1 CitationsSource
Abstract Research question The study aimed to determine whether IVF or intrauterine growth restriction (IUGR) result in short neonatal telomeres, which could explain the higher risk of cardiovascular and metabolic disease described in these populations. Design This was an observational, analytical, cross-sectional, prospective study with controls in a tertiary hospital. The main outcome was to determine the leukocyte telomere length in 126 newborns and their mothers ( n = 109). Newborns were con...
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#1Alfredo Perales-Puchalt (Wistar Institute)H-Index: 15
#2Krzysztof Wojtak (Wistar Institute)H-Index: 2
Last.David B. Weiner (Wistar Institute)H-Index: 81
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Ovarian cancer presents in 80% of patients as a metastatic disease, which confers it with dismal prognosis despite surgery and chemotherapy. However, it is an immunogenic disease, and the presence of intratumoral T cells is a major prognostic factor for survival. We used a synthetic consensus (SynCon) approach to generate a novel DNA vaccine that breaks immune tolerance to follicle-stimulating hormone receptor (FSHR), present in 50% of ovarian cancers but confined to the ovary in healthy tissues...
1 CitationsSource
#1Elizabeth K. Duperret (Wistar Institute)H-Index: 7
#2Alfredo Perales-Puchalt (Wistar Institute)H-Index: 15
Last.David B. Weiner (Wistar Institute)H-Index: 81
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T-cell recognition of cancer neoantigens is important for effective immune-checkpoint blockade therapy, and an increasing interest exists in developing personalized tumor neoantigen vaccines. Previous studies utilizing RNA and long-peptide neoantigen vaccines in preclinical and early-phase clinical studies have shown immune responses predominantly driven by MHC class II CD4+ T cells. Here, we report on a preclinical study utilizing a DNA vaccine platform to target tumor neoantigens. We showed th...
7 CitationsSource
#1Alfredo Perales-Puchalt (Wistar Institute)H-Index: 15
#2Nikolaos Svoronos (Wistar Institute)H-Index: 13
Last.David B. Weiner (Wistar Institute)H-Index: 81
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ABSTRACTOvarian cancer is frequently diagnosed as peritoneal carcinomatosis. Unlike other tumor locations, the peritoneal cavity is commonly exposed to gut-breaching and ascending genital microorga...
2 CitationsSource
Last.David B. WeinerH-Index: 81
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// Alfredo Perales-Puchalt 1 , Elizabeth K. Duperret 1 , Kar Muthumani 1 and David B. Weiner 1 1 Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA Correspondence to: David B. Weiner, email: weiner@Wistar.org Keywords : immunotherapy; cancer; immune checkpoints; DMAb; monoclonal antibody Received: December 13, 2018 Accepted: December 16, 2018 Published: January 01, 2019 Abstract Checkpoint inhibitors (CPI) have revolutionized the treatment of many solid tumors. However...
3 CitationsSource
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