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Bahram Shojadoost
Ontario Veterinary College
9Publications
5H-index
83Citations
Publications 10
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#1Bahram Shojadoost (Ontario Veterinary College)H-Index: 5
#2Raveendra R. Kulkarni (Ontario Veterinary College)H-Index: 13
Last.Shayan Sharif (Ontario Veterinary College)H-Index: 37
view all 10 authors...
Abstract Selenium supplementation in poultry feeds has been known to have beneficial effects on the bird health and performance; however antiviral effects of selenium have remained largely unknown. In this study, we have evaluated the effects of supplementation of chicken diets with organic (Selenium Enriched Yeast; SEY) and inorganic selenium (Sodium Selenite; SS) on low pathogenicity avian influenza virus (H9N2) shedding in the cloacal and oropharyngeal swab samples as well as examined the exp...
1 CitationsSource
#1Jake Astill (Ontario Veterinary College)H-Index: 3
#2Tamiru Negash Alkie (Ontario Veterinary College)H-Index: 7
Last.Shayan Sharif (Ontario Veterinary College)H-Index: 37
view all 8 authors...
Abstract Low pathogenic avian influenza virus (AIV) infection in chickens can result in economic losses and has impacts on human health. Poultry vaccination is a tool that can be used to decrease infection and transmission of AIVs. Prior research has demonstrated that Toll-like receptor (TLR) ligands can act as vaccine adjuvants and their addition to inactivated AIV vaccines can enhance immune responses elicited in chickens. The objective of this study was to compare the adjuvant capabilities of...
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#1Khaled Taha-Abdelaziz (Ontario Veterinary College)H-Index: 6
#2Tamiru Negash Alkie (Ontario Veterinary College)H-Index: 7
Last.Shayan Sharif (Ontario Veterinary College)H-Index: 37
view all 6 authors...
• Soluble and PLGA-encapsulated-CpG ODN, and C. jejuni lysate elicit cytokine expression in the intestinal tissue.
5 CitationsSource
#1Bahram Shojadoost (Ontario Veterinary College)H-Index: 5
#2Raveendra R. Kulkarni (Ontario Veterinary College)H-Index: 13
Last.Shayan Sharif (Ontario Veterinary College)H-Index: 37
view all 6 authors...
Abstract Macrophages are an important cell type of the innate immune system that upon activation, can exert antiviral functions and also can induce virus-specific adaptive immune responses. Macrophage interaction with certain probiotic bacteria such as lactobacilli can enhance antiviral functions of these cells. We have previously shown that administration of lactobacilli to chickens can effectively augment immune response to vaccine antigens. Here, we investigated the effects of representative ...
4 CitationsSource
#1Khaled Taha-Abdelaziz (Ontario Veterinary College)H-Index: 6
#2Tamiru Negash Alkie (Ontario Veterinary College)H-Index: 7
Last.Shayan Sharif (Ontario Veterinary College)H-Index: 37
view all 5 authors...
The innate responses of cecal tonsils against invading microorganisms are mediated by conserved pattern recognition receptors (PRRs) such as the Toll-like receptors (TLRs). TLRs expressed by mammalian and avian immune system cells have the capability to recognize pathogen-associated molecular patterns (PAMPs). Although, the role of TLR ligands in innate and adaptive responses in chickens has been characterized in spleen and bursa of Fabricius, considerably less is known about responses in cecal ...
13 CitationsSource
#1John F. Prescott (U of G: University of Guelph)H-Index: 47
#2Joan A. Smyth (UConn: University of Connecticut)H-Index: 24
Last.Andrew R. Vince (U of G: University of Guelph)H-Index: 2
view all 4 authors...
This review discusses key factors important in successful experimental reproduction of necrotic enteritis (NE) in chickens, and how these factors can be adjusted to affect the severity of the lesions induced. The critical bacterial factor is the need to use virulent, netB-positive, strains of Clostridium perfringens; disease severity can be enhanced by using netB-positive C. perfringens strains that are also tpeL-positive, by the use of young rather than old broth cultures, and by the number of ...
19 CitationsSource
#1Neda Barjesteh (U of G: University of Guelph)H-Index: 11
#2Bahram Shojadoost (U of G: University of Guelph)H-Index: 5
Last.Shayan Sharif (U of G: University of Guelph)H-Index: 37
view all 7 authors...
Abstract Avian influenza viruses (AIV) are of concern to the poultry industry. Outbreaks of AIV highlight the urgent need for effective control measures. Prophylactic strategies should be explored that rapidly elicit immunity against the virus. Toll-like receptors (TLRs) are innate immune molecules that can induce anti-viral responses, therefore the application of TLR ligands as prophylactic agents in chickens is gaining more attention. We hypothesized that treatment of chickens with TLR ligands...
22 CitationsSource
#1Shirene M. Singh (Ontario Veterinary College)H-Index: 4
#2Tamiru Negash Alkie (Ontario Veterinary College)H-Index: 7
Last.Shayan Sharif (Ontario Veterinary College)H-Index: 37
view all 6 authors...
Abstract Commercial vaccines against avian influenza viruses (AIV) in chickens consist mainly of inactivated AIV, requiring parenteral administration and co-delivery of an adjuvant. Limitations in T helper 1 or T helper 2 biased responses generated by these vaccines emphasize the need for alternative, more efficacious adjuvants. The Toll-like receptor (TLR) 21 ligand, CpG oligodeoxynucleotides (ODN), has been established as immunomodulatory in chickens. Therefore, the objective of this study was...
12 CitationsSource
#1Bahram Shojadoost (Ontario Veterinary College)H-Index: 5
#2Shahriar Behboudi (Institute for Animal Health)H-Index: 20
Last.Shayan Sharif (Ontario Veterinary College)H-Index: 7
view all 6 authors...
Abstract Vitamin D 3 is known to modulate both innate and adaptive immune responses in mammals, but there is little information on its effects on avian immune system cells. Here, we studied the effects of vitamin D 3 on chicken macrophages. Chicken macrophages expressed vitamin D receptor (VDR) and lipopolysaccharide (LPS) stimulation increased their VDR expression. Macrophages were treated with 1,25(OH) 2 D 3 in the presence or absence of Toll-like receptor ligands, such as LPS and Pam 3 CSK 4 ...
7 CitationsSource
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