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Anton Buzdin
I.M. Sechenov First Moscow State Medical University
41Publications
9H-index
216Citations
Publications 35
Newest
#1Nicolas BorisovH-Index: 8
#2Maxim SorokinH-Index: 9
Last.Anton BuzdinH-Index: 9
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#2Maxim SorokinH-Index: 9
Last.Anton BuzdinH-Index: 9
view all 5 authors...
Source
#1Victor TkachevH-Index: 5
#2Maxim Sorokin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
Last.Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
view all 5 authors...
1 CitationsSource
#1Maria SuntsovaH-Index: 9
#2Nurshat Gaifullin (MSU: Moscow State University)H-Index: 8
Last.Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
view all 14 authors...
Comprehensive analysis of molecular pathology requires a collection of reference samples representing normal tissues from healthy donors. For the available limited collections of normal tissues from postmortal donors, there is a problem of data incompatibility, as different datasets generated using different experimental platforms often cannot be merged in a single panel. Here, we constructed and deposited the gene expression database of normal human tissues based on uniformly screened original ...
2 CitationsSource
#1Nicolas Borisov (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 8
#2Irina Shabalina (PetrSU: Petrozavodsk State University)H-Index: 5
Last.Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
view all 8 authors...
Background Harmonization techniques make different gene expression profiles and their sets compatible and ready for comparisons. Here we present a new bioinformatic tool termed Shambhala for harmonization of multiple human gene expression datasets obtained using different experimental methods and platforms of microarray hybridization and RNA sequencing.
5 CitationsSource
#1Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
#2Maxim Sorokin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
Last.Alexey Moiseev (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 1
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Abstract Molecular diagnostics is becoming one of the major drivers of personalized oncology. With hundreds of different approved anticancer drugs and regimens of their administration, selecting the proper treatment for a patient is at least nontrivial task. This is especially sound for the cases of recurrent and metastatic cancers where the standard lines of therapy failed. Recent trials demonstrated that mutation assays have a strong limitation in personalized selection of therapeutics, conseq...
Source
#1Nicolas Borisov (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 8
#2Anton Buzdin (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 9
Source
#1Tatiana Shtam (Petersburg Nuclear Physics Institute)H-Index: 2
#2Stanislav N. Naryzhny (Academy of Medical Sciences, United Kingdom)H-Index: 13
Last.A. V. MalekH-Index: 4
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Purpose The interaction between malignant cells and surrounding healthy tissues is a critical factor in the metastatic progression of breast cancer (BC). Extracellular vesicles, especially exosomes, are known to be involved in inter-cellular communication during cancer progression. In the study presented herein, we aimed to evaluate the role of circulating plasma exosomes in the metastatic dissemination of BC and to investigate the underlying molecular mechanisms of this phenomenon.
7 CitationsSource
#1Joseph Sarhan (Tufts University)H-Index: 3
#2Beiyun C. Liu (Tufts University)H-Index: 6
Last.Alexander PoltorakH-Index: 18
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Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and are endogenously regulated by a low-level constitutive feedback loop. However, little is known about the functions and origins of constitutive IFN. Recently, lipopolysaccharide (LPS)-induced IFN was implicated as a driver of necroptosis, a necrotic form of cell death downstream of receptor-interacting protein (RIP) kinase activation and executed by mixed lineage kinase like-domain (MLKL) protein. We found tha...
15 CitationsSource
#1Victor TkachevH-Index: 5
#2Maxim SorokinH-Index: 9
Last.Nicolas Borisov (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 8
view all 8 authors...
Here, we propose a heuristic technique of data trimming for SVM termed FLOating Window Projective Separator (FloWPS), tailored for personalized predictions based on molecular data. This procedure can operate with high throughput genetic datasets like gene expression or mutation profiles. Its application prevents SVM from extrapolation by excluding non-informative features. FloWPS requires training on the data for the individuals with known clinical outcomes to create a clinically-relevant classi...
3 CitationsSource
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