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Xue-Ping Lu
Jiangxi University of Traditional Chinese Medicine
EffluxP-glycoproteinMTT assayBrucinePharmacology
2Publications
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13Citations
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Semen Strychni has been extensively used as a Chinese herb, but its therapeutic window is narrowed by the strong toxicity of the compound, which limits its effectiveness. Radix Paeoniae Alba has been reported to reduce the toxic effects and increase the therapeutic effects of Semen Strychni, but the underlying mechanism remains unknown. This research aimed to explore the mechanism through which P-glycoprotein (P-gp) is modulated by Semen Strychni combined with Radix Paeoniae Alba in vitro. An MT...
1 CitationsSource
#1Lihua Chen (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 3
#2Xue-Ping Lu (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 1
Last. Wei-feng Zhu (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 4
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Fritillaria thunbergii Miq. has been widely used in traditional Chinese medicine for its expectorant, antitussive, antiinflammatory and analgesic properties. Moreover, modern pharmacological studies have demonstrated that F. thunbergii Miq. has efficacy in the treatment of leukemia and cancers of the liver and cervix. Although the alkaloid, peimine, is largely responsible for these pharmacological effects, it has very low oral bioavailability. The aim of this study was to investigate the intesti...
12 CitationsSource
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