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Hao Chen
Chinese Academy of Sciences
210Publications
37H-index
5,026Citations
Publications 210
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Abstract Deep-sea Bathymodiolus mussels are ubiquitous in most cold seeps and hydrothermal fields, where they have adapted to various toxic environments including high metal exposure. However, there is scarce knowledge of metal accumulation and metal-related biomarkers in B. mussels. Here, we present data for metal concentrations (Ag, Cd, Cr, Cu, Fe, Mn, Pb, and Zn) and metal related biomarkers (superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase-GPX, glutathione-GSH, metallothioneins...
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#1Liang Zheng (CAS: Chinese Academy of Sciences)H-Index: 2
#2Hao Chen (CAS: Chinese Academy of Sciences)H-Index: 21
Last.Dejun Li (CAS: Chinese Academy of Sciences)H-Index: 25
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Abstract Fertilization is a key management practice for maintaining or improving soil fertility in agro-ecosystems. Nevertheless, how fertilization strategies impact the status of soil microbial resource limitation is poorly understood. Here, we investigated the effects of long-term (11 years) fertilization on microbial resource limitation in a karst cropland under maize–soybean rotation. Soil microbial resource limitation was assessed using enzymatic stoichiometry. Six fertilization strategies ...
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Au nanoparticles (NPs) were prepared by UV light irradiation of a mixed solution of HAuCl4 and sodium deoxycholate (NaDC) under alkaline condition, in which NaDC served as both reducing agent and capping agent. The reaction was monitored by circular dichroism (CD) spectra, and it was found that the formed gold NPs could catalyze the oxidation of NaDC. A CD signal at ~283 nm in the UV region was observed for the oxidation product of NaDC. The intensity of the CD signal of the oxidation product wa...
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Effective and safe analgesics represent an unmet medical need for the treatment of acute and chronic pain. A series of N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaines were designed, synthesized and assayed, leading to the discovery of a benzylamine derivative (compound 4, SLL-039) as a highly selective and potent κ opioid agonist (κ, Ki=0.47 nM, κ/μ=682, κ/δ=283), which was confirmed by functional assays in vitro and antinociceptive assays in vivo. The in vivo effect could b...
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#1Wenwen Diao (CAS: Chinese Academy of Sciences)H-Index: 2
#2Xuezhi Tong (Capital Medical University)H-Index: 1
Last.Zhong-Can Ou-Yang (CAS: Chinese Academy of Sciences)H-Index: 2
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Glioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus allows the GBM cells to grow in the 3-D chambers. The GBM cells in this model showed specific properties on the aspects of cell morphology, proliferation, mi...
3 CitationsSource
A growing pool of transgenic mice expressing Cre-recombinases, together with Cre-dependent opsin viruses, provide good tools to manipulate specific neural circuits related to eyeblink conditioning (EBC). However, currently available methods do not enable to get fast and precise readout of optogenetic control when the freely-moving mice are receiving EBC training. In the current study, we describe a laser diode (LD)-optical fiber (OF)-Tetrode assembly that allows for simultaneous multiple units r...
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#1Ke Zhang (Fudan University)H-Index: 2
#2Yongqiang Hua (Fudan University)H-Index: 6
Last.Hao Chen (Fudan University)H-Index: 37
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Systemic inflammation and immune dysfunction have been proved to be associated with cancer progression and metastasis in various malignancies. The aim of this retrospective study was to evaluate the prognostic significance of pre-treatment systemic immune-inflammation index (SII) in patients with advanced pancreatic cancer. In total, 419 patients diagnosed with advanced pancreatic cancer, between January 2011 and December 2015, were retrospectively enrolled. The SII was developed based on a trai...
3 CitationsSource
#1Hao Chen (CAS: Chinese Academy of Sciences)H-Index: 37
#2Jie Yang (JLU: Jilin University)H-Index: 4
Last.Bailiang Wang (CAS: Chinese Academy of Sciences)H-Index: 12
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