Gabriel Uwaifo
Memorial Hospital of South Bend
EndocrinologyPlaceboWomen's Health InitiativeDiabetes mellitusMedicine
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Publications 5
#1Toni I. Pollin (UMB: University of Maryland, Baltimore)H-Index: 41
#2Tamara Isakova (UM: University of Miami)H-Index: 32
Last. Jarred B. McAteer (Broad Institute)H-Index: 24
view all 425 authors...
Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32 lipid-associated single-nucleotide polymorphisms modifies the effects of lifestyle and/or metformin interventions on lipid levels and nuclea...
31 CitationsSource
#1William H. Herman (GW: George Washington University)H-Index: 4
#2Yong Ma (GW: George Washington University)H-Index: 15
Last. E Barrett-Conor (UCSD: University of California, San Diego)H-Index: 151
view all 10 authors...
Abstract Objective To examine racial and ethnic differences in hemoglobin A1c (HbA1c) in people with Impaired Glucose Tolerance (IGT). Research Design and Methods We studied 3,819 individuals ≥ 25 years of age with IGT found to be eligible to participant in the Diabetes Prevention Program. HbA1c was compared among five racial and ethnic groups before and after adjustment for factors that differed among groups or might affect glycemia including age, sex, education, marital status, blood pressure,...
391 CitationsSource
#1Bette J. CaanH-Index: 79
#2Marian L. NeuhouserH-Index: 64
Last. Andrea Z. LaCroixH-Index: 102
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Background: Obesity in the United States has increased significantly during the past several decades. The role of calcium in the maintenance of a healthy body weight remains controversial. Methods: A randomized, double-blinded, placebocontrolled trial was performed with 36 282 postmenopausal women, aged 50 to 79 years, who were already enrolled in the dietary modification and/or hormone therapy arms of the Women’s Health Initiative clinical trial. Women were randomized at their first or second a...
113 CitationsSource
#1J. David Curb (U.H.: University of Hawaii at Manoa)H-Index: 58
#2Ross L. Prentice (UW: University of Washington)H-Index: 90
Last. Frits R. Rosendaal (LEI: Leiden University)H-Index: 118
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Background: Postmenopausal hormone therapy has been associated with a 2- to 3-fold increased risk of venous thromboembolism (VT) (including deep vein thrombosis and pulmonary embolism) in observational studies and secondary prevention clinical trials. Clinical trial data on the effects of estrogen alone on VT are limited. Methods: The Women’s Health Initiative estrogen trial enrolled 10 739 women aged 50 to 79 years without a uterus. Participants were randomly assigned to receive conjugated equi...
143 CitationsSource
#2Ronald J. Prineas (Wake Forest University)H-Index: 62
Last. Mark E. MolitchH-Index: 70
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OBJECTIVE —Autonomic nervous system dysfunction, a correlate of obesity and poor cardiorespiratory fitness, is associated with the development of diabetes. We tested whether estimates of autonomic nervous system function improved in the intensive lifestyle versus metformin or placebo arms of the Diabetes Prevention Program (DPP) and whether baseline or a change in autonomic nervous system function was associated with the development of diabetes over 3.2 years. RESEARCH DESIGN AND METHODS —In 2,9...
138 CitationsSource