Divya Arora
Publications 7
#1Deepika Prasad (IISc: Indian Institute of Science)H-Index: 1
#2Divya AroraH-Index: 4
Last.K. Muniyappa (IISc: Indian Institute of Science)H-Index: 1
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The RecX protein has attracted considerable interest because the recX mutants exhibit multiple phenotypes associated with RecA functions. To further our understanding of the functional relationship between recA and recX, the effect of different stress treatments on their expression profiles, cell yield and viability were investigated. A significant correlation was found between the expression of Mycobacterium smegmatis recA and recX genes at different stages of growth, and in response to differe...
#1Ritesh Rajesh Sevalkar (CSIR: Council of Scientific and Industrial Research)H-Index: 3
#2Divya AroraH-Index: 4
Last.Dibyendu Sarkar (CSIR: Council of Scientific and Industrial Research)H-Index: 11
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ABSTRACT A hallmark feature of Mycobacterium tuberculosis pathogenesis lies in the ability of the pathogen to survive within macrophages under a stressful environment. Thus, coordinated regulation of stress proteins is critically important for an effective adaptive response of M. tuberculosis, the failure of which results in elevated immune recognition of the tubercle bacilli with reduced survival during chronic infections. Here, we show that virulence regulator PhoP impacts the global regulatio...
#1Divya AroraH-Index: 4
#2Yogesh ChawlaH-Index: 4
Last.Vinay Kumar NandicooriH-Index: 19
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The cell wall of Mycobacterium tuberculosis (Mtb) is a complex structure that protects the pathogen in hostile environments. Peptidoglycan (PG), which helps determine the morphology of the cell envelope, undergoes substantial remodeling under stress. This meshwork of linear chains of sugars, crosslinked through attached peptides, is generated through the sequential action of enzymes termed transglycosylases and transpeptidases. The Mtb genome encodes two classical transglycosylases and four tran...
6 CitationsSource
#2S. B. GuptaH-Index: 4
Last.Avinash BajajH-Index: 22
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Current membrane targeting antimicrobials fail to target mycobacteria due to their hydrophobic membrane structure, ability to form drug-resistant biofilms, and their natural intracellular habitat within the confines of macrophages. In this work, we describe engineering of synthetic antimicrobial polymers (SAMPs) derived from biocompatible polyamides that can target drug-sensitive and drug-resistant mycobacteria with high selectivity. Structure–activity relationship studies revealed that reduced ...
4 CitationsSource
#1Aditya K. Sharma (Institute of Genomics and Integrative Biology)H-Index: 2
#2Divya AroraH-Index: 4
Last.Vinay Kumar NandicooriH-Index: 19
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Protein phosphatases play vital roles in phosphorylation-mediated cellular signaling. Although there are 11 serine/threonine protein kinases in Mycobacterium tuberculosis, only one serine/threonine phosphatase, PstP, has been identified. Although PstP has been biochemically characterized and multiple in vitro substrates have been identified, its physiological role has not yet been elucidated. In this study, we have investigated the impact of PstP on cell growth and survival of the pathogen in th...
14 CitationsSource
Abstract Mycobacterium tuberculosis is an adaptable intracellular pathogen, existing in both dormant as well as active disease-causing states. Here, we report systematic proteomic analyses of four strains, H37Ra, H37Rv, and clinical isolates BND and JAL, to determine the differences in protein expression patterns that contribute to their virulence and drug resistance. Resolution of lysates of the four strains by liquid chromatography, coupled to mass spectrometry analysis, identified a total of ...
17 CitationsSource
#2Udai PareekH-Index: 2
Last.Divya AroraH-Index: 4
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