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Mauricio A. Contreras
Beth Israel Deaconess Medical Center
Laser capture microdissectionSurgeryGene expressionIntimal hyperplasiaMedicine
35Publications
13H-index
442Citations
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Publications 34
Newest
#1Yael Vin (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 8
#2Saif G. PathanH-Index: 3
Last. Matthew D. PhaneufH-Index: 16
view all 12 authors...
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#1Cindy Huynh (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
#2Ting-Yu Shih (Harvard University)H-Index: 3
Last. Frank W. LoGerfo (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 56
view all 6 authors...
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#1Cindy HuynhH-Index: 1
#2Ting Shih (Harvard University)
Last. Frank W. LoGerfoH-Index: 56
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#1Thomas C.F. Bodewes (UU: Utrecht University)H-Index: 5
#2Joel M. Johnson (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
Last. Leena Pradhan Nabzdyk (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 18
view all 8 authors...
In an effort to inhibit the response to vascular injury that leads to intimal hyperplasia, this study investigated the in vivo efficacy of intraluminal delivery of thrombospondin-2 (TSP-2) small in...
1 CitationsSource
#1Thomas C.F. Bodewes (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
#2Joel M. Johnson (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
Last. Frank W. LoGerfo (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 56
view all 5 authors...
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#1Ravi Vissapragada (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
#2Mauricio A. Contreras (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 13
Last. Ajith J. Thomas (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 26
view all 9 authors...
Interactions between neural progenitor cells (NPC) and endothelial cells (EC) from adult vascular beds have been well explored previously. However, the factors and signaling mechanisms that regulate neurogenesis and angiogenesis are most prevalent during embryonic development. This study aimed to determine whether embryonic brain endothelial cells from the periventricular region (PVEC) present an advantage over adult brain EC in supporting NPC growth and differentiation. PVEC were isolated from ...
17 CitationsSource
#1Shannon LindermanH-Index: 1
#2Joel Araya (NU: Northeastern University)H-Index: 1
Last. Mauricio A. Contreras (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 13
view all 6 authors...
1 Citations
Introduction Intimal hyperplasia represents a complex pathologic vascular response to injury. Our group previously revealed that TSP-2 was associated with this response, and demonstrated that intraluminal delivery of TSP-2 siRNA can suppress the intimal hyperplastic response in an animal model. Furthermore, we have shown that siRNA can be incorporated into prosthetic graft material using a dip-coating technique. We sought to determine whether this method could be employed for siRNA delivery in o...
#1Wande B. PrattH-Index: 17
#2Julia D. GlaserH-Index: 2
Last. Frank W. LoGerfoH-Index: 56
view all 5 authors...
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#1Manoj Bhasin (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 37
#2Zhen Huang (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
Last. Frank W. LoGerfo (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 56
view all 12 authors...
Vein graft failure occurs between 1 and 6 months after implantation due to obstructive intimal hyperplasia, related in part to implantation injury. The cell-specific and temporal response of the transcriptome to vein graft implantation injury was determined by transcriptional profiling of laser capture microdissected endothelial cells (EC) and medial smooth muscle cells (SMC) from canine vein grafts, 2 hours (H) to 30 days (D) following surgery. Our results demonstrate a robust genomic response ...
17 CitationsSource
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