Iwona Bogacka
Pennington Biomedical Research Center
EndocrinologyPeroxisome proliferator-activated receptorMitochondrial biogenesisPioglitazoneLipid metabolism
What is this?
Publications 8
#1Iwona BogackaH-Index: 7
#2Thomas W. GettysH-Index: 32
Last. Steven R. SmithH-Index: 71
view all 8 authors...
OBJECTIVE —The sympathetic nervous system and thiazolidinediones control lipid metabolism and have been implicated in body weight regulation. This study was conducted to determine whether the simultaneous activation of these two signaling systems might synergize to exert beneficial effects on the expression of key genes involved in lipid metabolism and mitochondrial biogenesis in subcutaneous fat in nondiabetic subjects. RESEARCH DESIGN AND METHODS —A total of 57 women and men were randomized in...
26 CitationsSource
#1Barbara UkropcovaH-Index: 20
#2Olga SeredaH-Index: 7
Last. Steven R. SmithH-Index: 71
view all 8 authors...
Insulin resistance is associated with metabolic inflexibility, impaired switching of substrate oxidation from fatty acids to glucose in response to insulin. Impaired switching to fat oxidation in response to a high-fat diet (HFD) is hypothesized to contribute to insulin resistance. The objective of this study was to test the hypothesis that defects in substrate switching in response to insulin and a HFD are linked to reduced mitochondrial biogenesis and occur before the development of diabetes. ...
119 CitationsSource
#1Iwona BogackaH-Index: 7
#2Thomas W. GettysH-Index: 2
view all 8 authors...
#1Iwona Bogacka (University of Warmia and Mazury in Olsztyn)H-Index: 7
#2Barbara Ukropcova (Pennington Biomedical Research Center)H-Index: 20
Last. Steven R. Smith (Pennington Biomedical Research Center)H-Index: 71
view all 5 authors...
Introduction: Mitochondrial biogenesis is a complex process, and several factors and signaling pathways regulate this process in muscle or brown adipocytes. The aim of the study was to explore pathways affecting mitochondrial biogenesis and fatty acid oxidation (FAO) in human white adipocytes. Methods: Human preadipocytes obtained from liposuction samples were differentiated in vitro. On the 10th day of differentiation, 4 μm forskolin and 1 μm peroxisome proliferator-activated receptor-γ (PPARγ)...
103 CitationsSource
#1Iwona BogackaH-Index: 7
#2Hui XieH-Index: 22
Last. Steven R. SmithH-Index: 71
view all 4 authors...
Thiazolidenediones such as pioglitazone improve insulin sensitivity in diabetic patients by several mechanisms, including increased uptake and metabolism of free fatty acids in adipose tissue. The purpose of the present study was to determine the effect of pioglitazone on mitochondrial biogenesis and expression of genes involved in fatty acid oxidation in subcutaneous fat. Patients with type 2 diabetes were randomly divided into two groups and treated with placebo or pioglitazone (45 mg/day) for...
335 CitationsSource
#1Leonie K. Heilbronn (Pennington Biomedical Research Center)H-Index: 37
#2Anthony E. Civitarese (Pennington Biomedical Research Center)H-Index: 10
Last. Eric Ravussin (Pennington Biomedical Research Center)H-Index: 101
view all 6 authors...
Objective: Alternate day fasting may extend lifespan in rodents and is feasible for short periods in nonobese humans. The aim of this study was to examine the effects of 3 weeks of alternate day fasting on glucose tolerance and skeletal muscle expression of genes involved in fatty acid transport/oxidation, mitochondrial biogenesis, and stress response. Research Methods and Procedures: Glucose and insulin responses to a standard meal were tested in nonobese subjects (eight men and eight women; BM...
95 CitationsSource
#1Iwona BogackaH-Index: 7
#2Hui XieH-Index: 22
Last. Steven R. SmithH-Index: 71
view all 4 authors...
OBJECTIVE —Pioglitazone is a member of the thiazolidinediones (TZDs), insulin-sensitizing agents used to treat type 2 diabetes. The aim of this study was to define the effect of pioglitazone on the expression of genes related to carbohydrate and lipid metabolism in subcutaneous fat obtained from type 2 diabetic patients. RESEARCH DESIGN AND METHODS —Forty-eight volunteers with type 2 diabetes were divided into two groups treated for 12 weeks with placebo or pioglitazone (30 mg/day). The expressi...
165 CitationsSource
#1Iwona Bogacka (Pennington Biomedical Research Center)H-Index: 7
#2David S. Roane (ULM: University of Louisiana at Monroe)H-Index: 9
Last. Roy J. Martin (Pennington Biomedical Research Center)H-Index: 23
view all 7 authors...
AbstractIt has been suggested that certain cells in the brain, like pancreatic β-cells, use glucose transporter-2 (GLUT-2), glucokinase and glucagon-like peptide-1 receptor (GLP-1R) to sense glucose in the service of multiple aspects of energy balance. The obese Zucker rat displays numerous disturbances in energy homeostasis and may provide a model of dysfunctional expression of genes related to nutrient control systems. Using real-time RT-PCR we measured gene expression for three of the pancrea...
17 CitationsSource