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Robert Callahan
National Institutes of Health
158Publications
52H-index
8,530Citations
Publications 156
Newest
#2Ahmed RaafatH-Index: 18
Last.David S. SalomonH-Index: 59
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The master regulators of embryonic development, Cripto and Notch, play key roles in modulating mammary gland morphogenesis and cell fate specification in the embryo through fetal mammary stem cells and in the adult organism particularly within the adult mammary stem cells, which determine mammary progenitor cell lineages that generate the basal/myoepithelial and luminal compartments of the adult mammary gland. Together with recognized transcription factors and embryonic stem cell markers, these ...
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#1Ahmed Raafat (NIH: National Institutes of Health)H-Index: 18
#2Sharon Bargo (NIH: National Institutes of Health)H-Index: 7
Last.Robert Callahan (NIH: National Institutes of Health)H-Index: 52
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Transgenic mice expressing the Notch-4 intracellular domain (designated Int3) in the mammary gland have two phenotypes exhibited with 100% penetrance: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch-4 signaling is mediated primarily through the interaction of Int3 with the transcription repressor/activator Rbpj. Interestingly, WAP-Int3/Rbpj knockout mice have normal mammary gland development but still developed mammary tumors with a slightly longer latency than th...
2 CitationsSource
#1Robert Callahan (NIH: National Institutes of Health)H-Index: 52
#2Barry A. Chestnut (NIH: National Institutes of Health)H-Index: 2
Last.Ahmed Raafat (NIH: National Institutes of Health)H-Index: 18
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Wap-Int3 transgenic females expressing the Notch4 intracellular domain (designated Int3) from the whey acidic protein promoter exhibit two phenotypes in the mammary gland: blockage of lobuloalveolar development and lactation, and tumor development with 100% penetrance. Previously, we have shown that treatment of Wap-Int3 tumor bearing mice with Imatinib mesylate (Gleevec) is associated with complete regression of the tumor. In the present study, we show that treatment of Wap-Int3 mice during day...
2 CitationsSource
#1Malgorzata Klauzinska (NIH: National Institutes of Health)H-Index: 9
#2David McCurdy (NIH: National Institutes of Health)H-Index: 4
Last.Ahmed Raafat (NIH: National Institutes of Health)H-Index: 18
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Cripto-1, a member of the epidermal growth factor–Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development. Together with its ligand Nodal, Cripto-1 has been found to be associated with the undifferentiated status of mouse and human embryonic stem cells. Several studies have clearly shown that Cripto-1 is involved in regulating branching morphogenesis and epithelial-mesenchymal transition of the mammary gland both in vitro and in vivo and together with the cofactor GRP78 is cri...
4 CitationsSource
#1Ahmed RaafatH-Index: 18
#2Sharon BargoH-Index: 7
Last.Robert CallahanH-Index: 52
view all 3 authors...
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Transgenic mice expressing the Notch 4 intracellular domain (ICD) (Int3) in the mammary gland have two phenotypes exhibited with 100% penetrance: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch4 signaling is mediated primarily through the interaction of Int3 with the transcription repressor/activator Rbpj. Interestingly, Rbpj knockout mice (Wap-Cre+/Rbpj-/-/Wap-Int3) have normal mammary gl...
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#2Ahmed RaafatH-Index: 18
Last.David S. SalomonH-Index: 59
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Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC The embryonic gene Cripto-1 (Cr-1) is expressed at very low levels in normal adult tissues and detected at high levels in several human tumors. We have previously found that Cr-1 can facilitate the proteolytic intracellular processing of all four Notch receptors. Transgenic mice overexpressing the Notch4 intracellular domain (Int3) in the mammary gland under the control of the whey acidic protein (WAP) promoter rapidly d...
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#1J M RobbinsH-Index: 2
#2Daniel GallahanH-Index: 18
Last.Robert CallahanH-Index: 52
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#1Robert CallahanH-Index: 52
#2Uma MudunuriH-Index: 13
Last.Gilbert H. SmithH-Index: 44
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// Robert Callahan 1 , Uma Mudunuri 2 , Sharon Bargo 1 , Ahmed Raafat 1 , David McCurdy 1 , Corinne Boulanger 1 , William Lowther 1 , Robert Stephens 2 , Brian T. Luke 2 , Claudia Stewart 2,3 , Xiaolin Wu 2,3 , David Munroe 2,3 and Gilbert H. Smith 1 . 1 Cell and Cancer Biology Branch, National Cancer Institute; Bethesda, MD, USA 2 Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD, USA 3 Laboratory of Molecular Technology, SAIC-Frederick, Inc., NCI-Frederick, Freder...
22 CitationsSource
#1Ahmed Raafat (NIH: National Institutes of Health)H-Index: 18
#2Luigi Strizzi (NU: Northwestern University)H-Index: 35
Last.Robert Callahan (NIH: National Institutes of Health)H-Index: 52
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The FVB/N mouse strain is extensively used in the development of animal models for breast cancer research. Recently it has been reported that the aging FVB/N mice develop spontaneous mammary lesions and tumors accompanied with abnormalities in the pituitary glands. These observations have a great impact on the mouse models of human breast cancer. We have developed a population of inbred FVB/N mice (designated FVB/N-RC) that have been genetically isolated for 20 years. To study the effects of age...
20 CitationsSource
#1Malgorzata Klauzinska (NIH: National Institutes of Health)H-Index: 9
#2Bolormaa Baljinnyam (NIH: National Institutes of Health)H-Index: 4
Last.Robert Callahan (NIH: National Institutes of Health)H-Index: 52
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Rspo2 was identified as a novel common integration site (CIS) for the mouse mammary tumor virus (MMTV) in viral induced mouse mammary tumors. Here we show that Rspo2 modulates Wnt signaling in mouse mammary epithelial cells. Co-expression of both genes resulted in an intermediate growth phenotype on plastic and had minor effects on the growth-promoting properties of Wnt1 in soft agar. However, individual Rspo2 and Wnt1 HC11 transfectants as well as the double transfectant were tumorigenic in ath...
26 CitationsSource
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