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Jennifer M. Lee
National Institutes of Health
23Publications
14H-index
3,081Citations
Publications 23
Newest
#1Melissa J. Landrum (NIH: National Institutes of Health)H-Index: 13
#2Jennifer M. Lee (NIH: National Institutes of Health)H-Index: 14
Last.Donna Maglott (NIH: National Institutes of Health)H-Index: 40
view all 22 authors...
#1Wendy S. Rubinstein (NIH: National Institutes of Health)H-Index: 35
#2Malheiro A (NIH: National Institutes of Health)H-Index: 3
Last.Jennifer M. Lee (NIH: National Institutes of Health)H-Index: 14
view all 12 authors...
e13120Background: Genetic testing of tumors and germlines has proliferated in oncology, as gauged by ASCO’s meeting topics and the medical literature. A quantitative appraisal of orderable genetic tests over recent years can provide insight into the evolution of oncology practice. GTR (https://www.ncbi.nlm.nih.gov/gtr/) is a freely available web resource created to enable centralized access to comprehensive information about genetic tests and improve transparency. GTR panel analyses were used by...
#1Steven M. Harrison (Partners HealthCare)H-Index: 13
#2Erin Rooney Riggs (GHS: Geisinger Health System)H-Index: 11
Last.Heidi L. Rehm (Partners HealthCare)H-Index: 51
view all 10 authors...
ClinVar is a freely accessible, public archive of reports of the relationships among genomic variants and phenotypes. To facilitate evaluation of the clinical significance of each variant, ClinVar aggregates submissions of the same variant, displays supporting data from each submission, and determines if the submitted clinical interpretations are conflicting or concordant. The unit describes how to (1) identify sequence and structural variants of interest in ClinVar by multiple searching approac...
#1Melissa J. Landrum (NIH: National Institutes of Health)H-Index: 13
#2Jennifer M. Lee (NIH: National Institutes of Health)H-Index: 14
Last.Donna Maglott (NIH: National Institutes of Health)H-Index: 40
view all 19 authors...
ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/) at the National Center for Biotechnology Information (NCBI) is a freely available archive for interpretations of clinical significance of variants for reported conditions. The database includes germline and somatic variants of any size, type or genomic location. Interpretations are submitted by clinical testing laboratories, research laboratories, locus-specific databases, OMIM®, GeneReviews™, UniProt, expert panels and practice guidelines. In NCBI...
#1Yugang Bai (UIUC: University of Illinois at Urbana–Champaign)H-Index: 10
#2Hang Xing (UIUC: University of Illinois at Urbana–Champaign)H-Index: 20
Last.Steven C. ZimmermanH-Index: 51
view all 9 authors...
The functional groups displayed on the surface of nanoparticles (NP) are known to play an important role in NP cellular uptake. However, only a few systematic studies have been reported to address their role, in large part because of the difficulty in regularly varying the number and structure of the functional groups on the NP surface. We employ a bottom-up strategy for the synthesis of water-soluble organic nanoparticles (ONPs) with different sizes and functional groups, using readily availabl...
#1Wendy S. Rubinstein (NIH: National Institutes of Health)H-Index: 35
#2Mark Benson (NIH: National Institutes of Health)H-Index: 2
Last.Jennifer M. Lee (NIH: National Institutes of Health)H-Index: 14
view all 10 authors...
e12543 Background: Oncology professionals have no centralized resource to locate the specific set of genetic tests relevant to their practice. Instead they rely on education, marketing, and word of...
#1Wendy S. Rubinstein (NIH: National Institutes of Health)H-Index: 35
#2Brandi L. Kattman (NIH: National Institutes of Health)H-Index: 5
Last.James Ostell (NIH: National Institutes of Health)H-Index: 24
view all 14 authors...
11104 Background: Oncology professionals need to access and gauge information about tests for hereditary cancer predisposition, biomarkers, pharmacogenetic dosing and risk-based chemoprevention. NIH has created the Genetic Testing Registry (GTR; http://www.ncbi.nlm.nih.gov/gtr/), a freely available, web-based resource to enable centralized access to comprehensive information about genetic tests and improve transparency. Methods: GTR was implemented by the National Center for Biotechnology Inform...
#1Yugang Bai (UIUC: University of Illinois at Urbana–Champaign)H-Index: 10
#2Hang Xing (UIUC: University of Illinois at Urbana–Champaign)H-Index: 20
Last.Steven C. Zimmerman (UIUC: University of Illinois at Urbana–Champaign)H-Index: 51
view all 8 authors...
A new approach to prepare functional organic nanoparticles (ONPs) from linear polymers is described. The nanoparticles are obtained by ring-opening metathesis polymerisation (ROMP) of functionalised norbornene dicarboximides, side-chain amidation with tri-O-allyl-TRIS, and ring-closing metathesis (RCM). The synthesis is quite flexible and mild, allowing preparation of organic- and aqueous-soluble particles with narrow molecular weight (MW) distributions that are tunable, ranging from MW ≈ 10 to ...
#1Melissa J. Landrum (NIH: National Institutes of Health)H-Index: 13
#2Jennifer M. Lee (NIH: National Institutes of Health)H-Index: 14
Last.Donna Maglott (NIH: National Institutes of Health)H-Index: 40
view all 7 authors...
ClinVar (http://www.ncbi.nlm.nih.gov/clinvar/) provides a freely available archive of reports of relationships among medically important variants and phenotypes. ClinVar accessions submissions reporting human variation, interpretations of the relationship of that variation to human health and the evidence supporting each interpretation. The database is tightly coupled with dbSNP and dbVar, which maintain information about the location of variation on human assemblies. ClinVar is also based on th...
#1Andrew J. Eckert (VCU: Virginia Commonwealth University)H-Index: 25
#2Jill L. Wegrzyn (UC Davis: University of California, Davis)H-Index: 29
Last.David B. Neale (UC Davis: University of California, Davis)H-Index: 49
view all 12 authors...
A primary goal of evolutionary genetics is to discover and explain the genetic basis of fitness-related traits and how this genetic basis evolves within natural populations. Unprecedented technological advances have fueled the discovery of genetic variants associated with ecologically relevant phenotypes in many different life forms, as well as the ability to scan genomes for deviations from selectively neutral models of evolution. Theoretically, the degree of overlap between lists of genomic re...
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